Cellular Entry of Binary and Pore-Forming Bacterial Toxins
Bridging cellular membranes is a key step in the pathogenic action of both binary and pore-forming bacterial toxins. The former use their translocation domains, containing various structural motifs, to ensure efficient delivery of the toxic component into the host cell, while the latter act on the c...
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| Format: | Online |
| Język: | angielski |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Hasła przedmiotowe: | |
| Dostęp online: | 25369 |
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| _version_ | 1869523529071853568 |
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| author | Alexey S. Ladokhin (Ed.) |
| author_browse | Alexey S. Ladokhin (Ed.) |
| author_facet | Alexey S. Ladokhin (Ed.) |
| author_sort | Alexey S. Ladokhin (Ed.) |
| collection | Directory of Open Access Books |
| description | Bridging cellular membranes is a key step in the pathogenic action of both binary and pore-forming bacterial toxins. The former use their translocation domains, containing various structural motifs, to ensure efficient delivery of the toxic component into the host cell, while the latter act on the cellular membrane itself. In either case, the integrity of the membrane is compromised via targeted protein–lipid and protein–protein interactions triggered by specific signals, such as proteolytic cleavage or endosomal acidification. This Special Issue presents recent advances in characterizing functional, structural and thermodynamic aspects of the conformational switching and membrane interactions involved in the cellular entry of bacterial protein toxins. Deciphering the physicochemical principles underlying these processes is also a prerequisite for the use of protein engineering to develop toxin-based molecular vehicles capable of targeted delivery of therapeutic agents to tumors and other diseased tissues. |
| format | Online |
| id | doab-20.500.12854ir-42868 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-428682024-04-05T12:32:52Z Cellular Entry of Binary and Pore-Forming Bacterial Toxins Alexey S. Ladokhin (Ed.) QH301-705.5 membrane permeabilization and translocation toxin-membrane interactions bacterial protein toxins conformational switching toxin-based targeted delivery of therapeutic agents cellular uptake thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Bridging cellular membranes is a key step in the pathogenic action of both binary and pore-forming bacterial toxins. The former use their translocation domains, containing various structural motifs, to ensure efficient delivery of the toxic component into the host cell, while the latter act on the cellular membrane itself. In either case, the integrity of the membrane is compromised via targeted protein–lipid and protein–protein interactions triggered by specific signals, such as proteolytic cleavage or endosomal acidification. This Special Issue presents recent advances in characterizing functional, structural and thermodynamic aspects of the conformational switching and membrane interactions involved in the cellular entry of bacterial protein toxins. Deciphering the physicochemical principles underlying these processes is also a prerequisite for the use of protein engineering to develop toxin-based molecular vehicles capable of targeted delivery of therapeutic agents to tumors and other diseased tissues. 2021-02-11T09:37:00Z 2021-02-11T09:37:00Z 2018-02-08 13:26:54 2018 book 25369 9783038427032 9783038427049 https://directory.doabooks.org/handle/20.500.12854/42868 eng image/png Attribution-NonCommercial-NoDerivatives 4.0 International http://www.mdpi.com/books/pdfview/book/531 http://www.mdpi.com/books/pdfview/book/531 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03842-703-2 10.3390/books978-3-03842-703-2 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783038427032 9783038427049 128 open access |
| spellingShingle | QH301-705.5 membrane permeabilization and translocation toxin-membrane interactions bacterial protein toxins conformational switching toxin-based targeted delivery of therapeutic agents cellular uptake thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Alexey S. Ladokhin (Ed.) Cellular Entry of Binary and Pore-Forming Bacterial Toxins |
| title | Cellular Entry of Binary and Pore-Forming Bacterial Toxins |
| title_full | Cellular Entry of Binary and Pore-Forming Bacterial Toxins |
| title_fullStr | Cellular Entry of Binary and Pore-Forming Bacterial Toxins |
| title_full_unstemmed | Cellular Entry of Binary and Pore-Forming Bacterial Toxins |
| title_short | Cellular Entry of Binary and Pore-Forming Bacterial Toxins |
| title_sort | cellular entry of binary and pore forming bacterial toxins |
| topic | QH301-705.5 membrane permeabilization and translocation toxin-membrane interactions bacterial protein toxins conformational switching toxin-based targeted delivery of therapeutic agents cellular uptake thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | QH301-705.5 membrane permeabilization and translocation toxin-membrane interactions bacterial protein toxins conformational switching toxin-based targeted delivery of therapeutic agents cellular uptake thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | 25369 |
| work_keys_str_mv | AT alexeysladokhined cellularentryofbinaryandporeformingbacterialtoxins |