Cellular Mechanisms of Ototoxicity
The auditory perception of sounds (environmental, vocal or music) is one of the 5 principal senses consciously monitored by our brains, and is crucial for many human endeavors as well as quality of life. Loss of optimal performance in this principal sensory system leads to loss of effective communic...
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| Format: | Online |
| Język: | angielski |
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Frontiers Media SA
2021
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| Dostęp online: | 31894 |
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| _version_ | 1869522221637042176 |
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| author | Carlos Esquivel Kelly Watts Peter S. Steyger Jian Zuo Lisa Cunningham |
| author_browse | Carlos Esquivel Jian Zuo Kelly Watts Lisa Cunningham Peter S. Steyger |
| author_facet | Carlos Esquivel Kelly Watts Peter S. Steyger Jian Zuo Lisa Cunningham |
| author_sort | Carlos Esquivel |
| collection | Directory of Open Access Books |
| description | The auditory perception of sounds (environmental, vocal or music) is one of the 5 principal senses consciously monitored by our brains, and is crucial for many human endeavors as well as quality of life. Loss of optimal performance in this principal sensory system leads to loss of effective communication and intimacy, as well as increased risk of isolation, depression, cognitive decline, and greater vulnerability to predators. The vestibular system ensures that individuals remain upright and effectively monitor their posture within their spatial surroundings, move effectively, and remain focused on visual targets during motion. The loss of vestibular sensitivity results in postural instability, falls, inability to observe the environment during motion, and a debilitating incapacity to function effectively. The sensory cells for both auditory and vestibular systems are located within the inner ear of the temporal bulla. There are many causes of auditory and vestibular deficits, including congenital (or genetic) events, trauma, aging and loud sound exposures. Ototoxicity refers to damage of the auditory or vestibular structures or functions, as the result of exposure to certain pharmaceuticals, chemicals, and/or ionizing radiation exposure that damage the inner ear. Ototoxicity is a major contributor to acquired hearing loss and vestibular deficits, and is entirely preventable. In 2009, the United States Department of Defense initiated the Hearing Center of Excellence (HCE), headquartered in San Antonio, Texas, in response to the prevalence of acquired auditory and vestibular deficits in military and veteran populations. The knowledge shared in this eBook supports the HCE’s mandate to improve aural protection of military and civilian populations worldwide. The last few years have seen significant advances in understanding the cellular mechanisms underlying ototoxic drug-induced hearing loss and vestibular deficits. In this eBook, we present some of these advances and highlight gaps where further research is needed. Selected articles discuss candidate otoprotective agents that can ameliorate the effects of ototoxicity in the context of how they illustrate cellular mechanisms of ototoxicity. Our goal in illustrating these advances in mechanisms of ototoxicity is to accelerate the development of clinical therapies that prevent or reverse this debilitating disorder. |
| format | Online |
| id | doab-20.500.12854ir-42869 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-428692024-04-05T12:36:20Z Cellular Mechanisms of Ototoxicity Carlos Esquivel Kelly Watts Peter S. Steyger Jian Zuo Lisa Cunningham RC321-571 Q1-390 blood-labyrinth barrier neurotoxicity otoprotection aminoglycosides ototoxic synergy sensory disorders cisplatin thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences The auditory perception of sounds (environmental, vocal or music) is one of the 5 principal senses consciously monitored by our brains, and is crucial for many human endeavors as well as quality of life. Loss of optimal performance in this principal sensory system leads to loss of effective communication and intimacy, as well as increased risk of isolation, depression, cognitive decline, and greater vulnerability to predators. The vestibular system ensures that individuals remain upright and effectively monitor their posture within their spatial surroundings, move effectively, and remain focused on visual targets during motion. The loss of vestibular sensitivity results in postural instability, falls, inability to observe the environment during motion, and a debilitating incapacity to function effectively. The sensory cells for both auditory and vestibular systems are located within the inner ear of the temporal bulla. There are many causes of auditory and vestibular deficits, including congenital (or genetic) events, trauma, aging and loud sound exposures. Ototoxicity refers to damage of the auditory or vestibular structures or functions, as the result of exposure to certain pharmaceuticals, chemicals, and/or ionizing radiation exposure that damage the inner ear. Ototoxicity is a major contributor to acquired hearing loss and vestibular deficits, and is entirely preventable. In 2009, the United States Department of Defense initiated the Hearing Center of Excellence (HCE), headquartered in San Antonio, Texas, in response to the prevalence of acquired auditory and vestibular deficits in military and veteran populations. The knowledge shared in this eBook supports the HCE’s mandate to improve aural protection of military and civilian populations worldwide. The last few years have seen significant advances in understanding the cellular mechanisms underlying ototoxic drug-induced hearing loss and vestibular deficits. In this eBook, we present some of these advances and highlight gaps where further research is needed. Selected articles discuss candidate otoprotective agents that can ameliorate the effects of ototoxicity in the context of how they illustrate cellular mechanisms of ototoxicity. Our goal in illustrating these advances in mechanisms of ototoxicity is to accelerate the development of clinical therapies that prevent or reverse this debilitating disorder. 2021-02-11T09:37:02Z 2021-02-11T09:37:02Z 2019-01-23 14:53:42 2018 book 31894 16648714 9782889454839 https://directory.doabooks.org/handle/20.500.12854/42869 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/5317/cellular-mechanisms-of-ototoxicity Frontiers Media SA 10.3389/978-2-88945-483-9 10.3389/978-2-88945-483-9 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889454839 292 open access |
| spellingShingle | RC321-571 Q1-390 blood-labyrinth barrier neurotoxicity otoprotection aminoglycosides ototoxic synergy sensory disorders cisplatin thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Carlos Esquivel Kelly Watts Peter S. Steyger Jian Zuo Lisa Cunningham Cellular Mechanisms of Ototoxicity |
| title | Cellular Mechanisms of Ototoxicity |
| title_full | Cellular Mechanisms of Ototoxicity |
| title_fullStr | Cellular Mechanisms of Ototoxicity |
| title_full_unstemmed | Cellular Mechanisms of Ototoxicity |
| title_short | Cellular Mechanisms of Ototoxicity |
| title_sort | cellular mechanisms of ototoxicity |
| topic | RC321-571 Q1-390 blood-labyrinth barrier neurotoxicity otoprotection aminoglycosides ototoxic synergy sensory disorders cisplatin thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 blood-labyrinth barrier neurotoxicity otoprotection aminoglycosides ototoxic synergy sensory disorders cisplatin thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 31894 |
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