Chemical and Molecular Approach to Tumor Metastases
Dear Colleagues, Malignant tumors develop distant metastases, e.g., small clusters of cells that detach from the primitive site and colonize distant organs and tissues. Unlike the primary masses, metastases are often difficult to fully eradicate by surgery ablation and are almost always the primary...
Đã lưu trong:
| Những tác giả chính: | , |
|---|---|
| Định dạng: | Online |
| Ngôn ngữ: | Tiếng Anh |
| Được phát hành: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
|
| Những chủ đề: | |
| Truy cập trực tuyến: | 27258 |
| Các nhãn: |
Không có thẻ, Là người đầu tiên thẻ bản ghi này!
|
| _version_ | 1869514791197868032 |
|---|---|
| author | Gianni Sava (Ed.) Alberta Bergamo (Ed.) |
| author_browse | Alberta Bergamo (Ed.) Gianni Sava (Ed.) |
| author_facet | Gianni Sava (Ed.) Alberta Bergamo (Ed.) |
| author_sort | Gianni Sava (Ed.) |
| collection | Directory of Open Access Books |
| description | Dear Colleagues, Malignant tumors develop distant metastases, e.g., small clusters of cells that detach from the primitive site and colonize distant organs and tissues. Unlike the primary masses, metastases are often difficult to fully eradicate by surgery ablation and are almost always the primary object of chemo- and/or immune-therapies. The presence of metastases at tumor diagnosis is responsible for the unfavorable prognosis and of relapses even after initially successful tumor therapies. The lack of success of chemo- and immune-therapy approaches depends on many factors among which, the inadequate capacity of the anti-tumor drugs of reaching appropriate concentrations in the organs and tissues involved in the metastatic growth is a major concern. Another factor is the complexity of the metastasis biology and of their molecular behavior, evidencing a population of tumor cells with a genetic compartment different from that of the tumor of origin. The involvement of host cells and factors recruited by the metastatic cells and committed to support the metastatic growth is also an event crucial for the lack of success of the anti-tumor therapy. The knowledge of the molecular biology of metastases is mandatory to support the search for chemical agents to treat the metastatic determinants and to control of the neoplastic disease. This Special Issue on “Chemical and Molecular Approach to Tumor Metastases” will explore the impact of biology, molecular medicine and chemistry on all aspects related to tumor metastases from the biological and molecular aspects of the metastatic growth, including the relationships between the metastatic cells and the host environment, and the search for druggable determinants useful for the chemical analysis of agents selectively active against tumor metastases. With the combination of invited reviews and original papers from prominent scientists working on all aspects of molecular medicine and cancer therapy, such as, but not limited to: drug delivery, genomics, chemoprevention, drug discovery, we aim to sample recent progress in molecular and chemical aspects of therapy of malignant tumors. Clinical success studies and evidences of novel compounds are particularly welcome. |
| format | Online |
| id | doab-20.500.12854ir-43069 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-430692024-04-05T12:31:46Z Chemical and Molecular Approach to Tumor Metastases Gianni Sava (Ed.) Alberta Bergamo (Ed.) QH301-705.5 RC254-282 innovative drugs genomics of metastasis molecular approaches chemotherapy biology of metastasis microenvironment chemical approaches metastasis niche metastasis druggable targets immunotherapy clinical studies tumor metastasis dynamics of metastasis epigenetics of metastasis thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Dear Colleagues, Malignant tumors develop distant metastases, e.g., small clusters of cells that detach from the primitive site and colonize distant organs and tissues. Unlike the primary masses, metastases are often difficult to fully eradicate by surgery ablation and are almost always the primary object of chemo- and/or immune-therapies. The presence of metastases at tumor diagnosis is responsible for the unfavorable prognosis and of relapses even after initially successful tumor therapies. The lack of success of chemo- and immune-therapy approaches depends on many factors among which, the inadequate capacity of the anti-tumor drugs of reaching appropriate concentrations in the organs and tissues involved in the metastatic growth is a major concern. Another factor is the complexity of the metastasis biology and of their molecular behavior, evidencing a population of tumor cells with a genetic compartment different from that of the tumor of origin. The involvement of host cells and factors recruited by the metastatic cells and committed to support the metastatic growth is also an event crucial for the lack of success of the anti-tumor therapy. The knowledge of the molecular biology of metastases is mandatory to support the search for chemical agents to treat the metastatic determinants and to control of the neoplastic disease. This Special Issue on “Chemical and Molecular Approach to Tumor Metastases” will explore the impact of biology, molecular medicine and chemistry on all aspects related to tumor metastases from the biological and molecular aspects of the metastatic growth, including the relationships between the metastatic cells and the host environment, and the search for druggable determinants useful for the chemical analysis of agents selectively active against tumor metastases. With the combination of invited reviews and original papers from prominent scientists working on all aspects of molecular medicine and cancer therapy, such as, but not limited to: drug delivery, genomics, chemoprevention, drug discovery, we aim to sample recent progress in molecular and chemical aspects of therapy of malignant tumors. Clinical success studies and evidences of novel compounds are particularly welcome. 2021-02-11T09:45:32Z 2021-02-11T09:45:32Z 2018-07-05 12:45:05 2018 book 27258 9783038428961 9783038428954 https://directory.doabooks.org/handle/20.500.12854/43069 eng image/png Attribution-NonCommercial-NoDerivatives 4.0 International http://www.mdpi.com/books/pdfview/book/668 http://www.mdpi.com/books/pdfview/book/668 MDPI - Multidisciplinary Digital Publishing Institute 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783038428961 9783038428954 VIII, 256 open access |
| spellingShingle | QH301-705.5 RC254-282 innovative drugs genomics of metastasis molecular approaches chemotherapy biology of metastasis microenvironment chemical approaches metastasis niche metastasis druggable targets immunotherapy clinical studies tumor metastasis dynamics of metastasis epigenetics of metastasis thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Gianni Sava (Ed.) Alberta Bergamo (Ed.) Chemical and Molecular Approach to Tumor Metastases |
| title | Chemical and Molecular Approach to Tumor Metastases |
| title_full | Chemical and Molecular Approach to Tumor Metastases |
| title_fullStr | Chemical and Molecular Approach to Tumor Metastases |
| title_full_unstemmed | Chemical and Molecular Approach to Tumor Metastases |
| title_short | Chemical and Molecular Approach to Tumor Metastases |
| title_sort | chemical and molecular approach to tumor metastases |
| topic | QH301-705.5 RC254-282 innovative drugs genomics of metastasis molecular approaches chemotherapy biology of metastasis microenvironment chemical approaches metastasis niche metastasis druggable targets immunotherapy clinical studies tumor metastasis dynamics of metastasis epigenetics of metastasis thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | QH301-705.5 RC254-282 innovative drugs genomics of metastasis molecular approaches chemotherapy biology of metastasis microenvironment chemical approaches metastasis niche metastasis druggable targets immunotherapy clinical studies tumor metastasis dynamics of metastasis epigenetics of metastasis thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | 27258 |
| work_keys_str_mv | AT giannisavaed chemicalandmolecularapproachtotumormetastases AT albertabergamoed chemicalandmolecularapproachtotumormetastases |