Chemically-Induced DNA Damage, Mutagenesis, and Cancer
Human cancers frequently arise from exposure to chemicals, although radiation, oxidation, and genetic factors play critical roles as well. DNA damage by these agents in a cell is an important first step in the process of carcinogenesis. DNA repair processes have evolved to repair these damages. Howe...
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| Main Authors: | , |
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| Format: | Online |
| Language: | English |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Online Access: | 27502 |
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| _version_ | 1869526051824074752 |
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| author | Takehiko Nohmi (Ed.) Ashis K. Basu (Ed.) |
| author_browse | Ashis K. Basu (Ed.) Takehiko Nohmi (Ed.) |
| author_facet | Takehiko Nohmi (Ed.) Ashis K. Basu (Ed.) |
| author_sort | Takehiko Nohmi (Ed.) |
| collection | Directory of Open Access Books |
| description | Human cancers frequently arise from exposure to chemicals, although radiation, oxidation, and genetic factors play critical roles as well. DNA damage by these agents in a cell is an important first step in the process of carcinogenesis. DNA repair processes have evolved to repair these damages. However, the replication of damaged DNA may occur frequently prior to repair, resulting in gene mutations and the generation of altered proteins. Mutations in an oncogene, a tumor-suppressor gene, or a gene that controls the cell cycle give rise to a clonal cell population with an advantage in proliferation. The complex process of carcinogenesis includes many such events, but has been generally considered to be comprised of the three main stages known as initiation, promotion, and progression, which ultimately give rise to the induction of human cancer. The articles published in this book entitled “Chemically-Induced DNA Damage, Mutagenesis, and Cancer” provide an overview on the topic of the “consequence of DNA damage” in the context of human cancer with their challenges and highlights. |
| format | Online |
| id | doab-20.500.12854ir-43078 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-430782024-04-05T12:33:13Z Chemically-Induced DNA Damage, Mutagenesis, and Cancer Takehiko Nohmi (Ed.) Ashis K. Basu (Ed.) QH301-705.5 genotoxicity chemoprevention DNA damage metal toxicity apoptosis melanoma tumor cells DNA repair chemotherapy translesion synthesis thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Human cancers frequently arise from exposure to chemicals, although radiation, oxidation, and genetic factors play critical roles as well. DNA damage by these agents in a cell is an important first step in the process of carcinogenesis. DNA repair processes have evolved to repair these damages. However, the replication of damaged DNA may occur frequently prior to repair, resulting in gene mutations and the generation of altered proteins. Mutations in an oncogene, a tumor-suppressor gene, or a gene that controls the cell cycle give rise to a clonal cell population with an advantage in proliferation. The complex process of carcinogenesis includes many such events, but has been generally considered to be comprised of the three main stages known as initiation, promotion, and progression, which ultimately give rise to the induction of human cancer. The articles published in this book entitled “Chemically-Induced DNA Damage, Mutagenesis, and Cancer” provide an overview on the topic of the “consequence of DNA damage” in the context of human cancer with their challenges and highlights. 2021-02-11T09:45:53Z 2021-02-11T09:45:53Z 2018-08-27 13:43:27 2018 book 27502 9783038971290 9783038971306 https://directory.doabooks.org/handle/20.500.12854/43078 eng image/jpeg Attribution-NonCommercial-NoDerivatives 4.0 International https://play.google.com/books/ http://www.mdpi.com/books https://doi.org/10.3390/books978-3-03897-130-6 MDPI - Multidisciplinary Digital Publishing Institute 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783038971290 9783038971306 X, 264 open access |
| spellingShingle | QH301-705.5 genotoxicity chemoprevention DNA damage metal toxicity apoptosis melanoma tumor cells DNA repair chemotherapy translesion synthesis thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Takehiko Nohmi (Ed.) Ashis K. Basu (Ed.) Chemically-Induced DNA Damage, Mutagenesis, and Cancer |
| title | Chemically-Induced DNA Damage, Mutagenesis, and Cancer |
| title_full | Chemically-Induced DNA Damage, Mutagenesis, and Cancer |
| title_fullStr | Chemically-Induced DNA Damage, Mutagenesis, and Cancer |
| title_full_unstemmed | Chemically-Induced DNA Damage, Mutagenesis, and Cancer |
| title_short | Chemically-Induced DNA Damage, Mutagenesis, and Cancer |
| title_sort | chemically induced dna damage mutagenesis and cancer |
| topic | QH301-705.5 genotoxicity chemoprevention DNA damage metal toxicity apoptosis melanoma tumor cells DNA repair chemotherapy translesion synthesis thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | QH301-705.5 genotoxicity chemoprevention DNA damage metal toxicity apoptosis melanoma tumor cells DNA repair chemotherapy translesion synthesis thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | 27502 |
| work_keys_str_mv | AT takehikonohmied chemicallyinduceddnadamagemutagenesisandcancer AT ashiskbasued chemicallyinduceddnadamagemutagenesisandcancer |