Circulating Tumor Cells: Finding Rare Events for A Huge Knowledge of Cancer Dissemination
The analysis of circulating tumor cells (CTCs) as a real-time liquid biopsy approach can be used to obtain new insights into metastasis biology, and as companion diagnostics to improve the stratification of therapies and to obtain insights into the therapy-induced selection of cancer cells. In this...
שמור ב:
| מחבר ראשי: | |
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| פורמט: | Online |
| שפה: | אנגלית |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| נושאים: | |
| גישה מקוונת: | 45989 |
| תגים: |
אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!
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| _version_ | 1869524534667771904 |
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| author | Alix-Panabieres, Catherine |
| author_browse | Alix-Panabieres, Catherine |
| author_facet | Alix-Panabieres, Catherine |
| author_sort | Alix-Panabieres, Catherine |
| collection | Directory of Open Access Books |
| description | The analysis of circulating tumor cells (CTCs) as a real-time liquid biopsy approach can be used to obtain new insights into metastasis biology, and as companion diagnostics to improve the stratification of therapies and to obtain insights into the therapy-induced selection of cancer cells. In this book, we will cover all the different facets of CTCs to assemble a huge corpus of knowledge on cancer dissemination: technologies for their enrichment, detection, and characterization; their analysis at the single-cell level; their journey as CTC microemboli; their clinical relevance; their biology with the epithelial-to-mesenchymal transition (EMT); their stem-cell properties; their potential to initiate metastasis at distant sites; their ex vivo expansion; and their escape from the immune system. |
| format | Online |
| id | doab-20.500.12854ir-43261 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-432612024-03-31T13:11:13Z Circulating Tumor Cells: Finding Rare Events for A Huge Knowledge of Cancer Dissemination Alix-Panabieres, Catherine R5-920 n/a FOLFIRINOX immunofluorescence imaging AR-V7 circulating tumour cells chemoradioresistance CTC-based treatment decisions rVAR2 immunophenotyping immune system CellSearch® flow cytometry clinical trials circulating tumor DNA synaptophysin stem cells colorectal cancer melanoma CTC biology platelets AR CTC capture technology castration resistant prostate cancer (CRPC) PD-L1 expression rovalpituzumab tesirine HMB-45 thymidylate synthase ctDNA tumor cell dissemination solid cancers metastasis locally advanced rectal cancer miRNA epithelial-to-mesenchymal transition (EMT) NSCLC tumor biomarkers tumor stem cells circulating tumor cells major histocompatibility complex class I (MHCI) bone marrow heterogeneity cerebrospinal liquid biopsy fish glioma in vivo flow cytometry colorectal surgery CellSearch single-cell analysis disseminated tumor cells EasyCount slides microsatellite instability circulating plasma cells circulating leukemia cells ARV7 SLUG androgen receptor metastatic colorectal cancer leukocyte-derived extracellular vesicles prostate cancer (PCa) neutrophils liquid biopsy enzalutamide CD133 enrichment and detection technologies biomarkers immune checkpoint inhibitors biomarker RAD23B microbiome integrin B1 ACCEPT emboli small-cell lung carcinoma EPISPOT microfluidics early breast cancer circulating tumor cells (CTC) tumor-initiating cells (TICs) immunomodulation xenograft models CTC-derived xenografts malaria circulating tumor cells (CTCs) clinical utility exosomes liquid surgery ctRNA CTCs epithelial–mesenchymal transition targeted therapy hematological cells gene expression analysis hepatocellular carcinoma (HCC) breast cancer EpCAM enrichment prostate cancer CTC abiraterone fibronectin CTC-derived ex vivo models CTMat chromogranin A CTM exosome thema EDItEUR::M Medicine and Nursing The analysis of circulating tumor cells (CTCs) as a real-time liquid biopsy approach can be used to obtain new insights into metastasis biology, and as companion diagnostics to improve the stratification of therapies and to obtain insights into the therapy-induced selection of cancer cells. In this book, we will cover all the different facets of CTCs to assemble a huge corpus of knowledge on cancer dissemination: technologies for their enrichment, detection, and characterization; their analysis at the single-cell level; their journey as CTC microemboli; their clinical relevance; their biology with the epithelial-to-mesenchymal transition (EMT); their stem-cell properties; their potential to initiate metastasis at distant sites; their ex vivo expansion; and their escape from the immune system. 2021-02-11T09:53:56Z 2021-02-11T09:53:56Z 2020-06-09 16:38:57 2020 book 45989 9783039286997 9783039286980 https://directory.doabooks.org/handle/20.500.12854/43261 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/2163 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03928-699-7 10.3390/books978-3-03928-699-7 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039286997 9783039286980 366 open access |
| spellingShingle | R5-920 n/a FOLFIRINOX immunofluorescence imaging AR-V7 circulating tumour cells chemoradioresistance CTC-based treatment decisions rVAR2 immunophenotyping immune system CellSearch® flow cytometry clinical trials circulating tumor DNA synaptophysin stem cells colorectal cancer melanoma CTC biology platelets AR CTC capture technology castration resistant prostate cancer (CRPC) PD-L1 expression rovalpituzumab tesirine HMB-45 thymidylate synthase ctDNA tumor cell dissemination solid cancers metastasis locally advanced rectal cancer miRNA epithelial-to-mesenchymal transition (EMT) NSCLC tumor biomarkers tumor stem cells circulating tumor cells major histocompatibility complex class I (MHCI) bone marrow heterogeneity cerebrospinal liquid biopsy fish glioma in vivo flow cytometry colorectal surgery CellSearch single-cell analysis disseminated tumor cells EasyCount slides microsatellite instability circulating plasma cells circulating leukemia cells ARV7 SLUG androgen receptor metastatic colorectal cancer leukocyte-derived extracellular vesicles prostate cancer (PCa) neutrophils liquid biopsy enzalutamide CD133 enrichment and detection technologies biomarkers immune checkpoint inhibitors biomarker RAD23B microbiome integrin B1 ACCEPT emboli small-cell lung carcinoma EPISPOT microfluidics early breast cancer circulating tumor cells (CTC) tumor-initiating cells (TICs) immunomodulation xenograft models CTC-derived xenografts malaria circulating tumor cells (CTCs) clinical utility exosomes liquid surgery ctRNA CTCs epithelial–mesenchymal transition targeted therapy hematological cells gene expression analysis hepatocellular carcinoma (HCC) breast cancer EpCAM enrichment prostate cancer CTC abiraterone fibronectin CTC-derived ex vivo models CTMat chromogranin A CTM exosome thema EDItEUR::M Medicine and Nursing Alix-Panabieres, Catherine Circulating Tumor Cells: Finding Rare Events for A Huge Knowledge of Cancer Dissemination |
| title | Circulating Tumor Cells: Finding Rare Events for A Huge Knowledge of Cancer Dissemination |
| title_full | Circulating Tumor Cells: Finding Rare Events for A Huge Knowledge of Cancer Dissemination |
| title_fullStr | Circulating Tumor Cells: Finding Rare Events for A Huge Knowledge of Cancer Dissemination |
| title_full_unstemmed | Circulating Tumor Cells: Finding Rare Events for A Huge Knowledge of Cancer Dissemination |
| title_short | Circulating Tumor Cells: Finding Rare Events for A Huge Knowledge of Cancer Dissemination |
| title_sort | circulating tumor cells finding rare events for a huge knowledge of cancer dissemination |
| topic | R5-920 n/a FOLFIRINOX immunofluorescence imaging AR-V7 circulating tumour cells chemoradioresistance CTC-based treatment decisions rVAR2 immunophenotyping immune system CellSearch® flow cytometry clinical trials circulating tumor DNA synaptophysin stem cells colorectal cancer melanoma CTC biology platelets AR CTC capture technology castration resistant prostate cancer (CRPC) PD-L1 expression rovalpituzumab tesirine HMB-45 thymidylate synthase ctDNA tumor cell dissemination solid cancers metastasis locally advanced rectal cancer miRNA epithelial-to-mesenchymal transition (EMT) NSCLC tumor biomarkers tumor stem cells circulating tumor cells major histocompatibility complex class I (MHCI) bone marrow heterogeneity cerebrospinal liquid biopsy fish glioma in vivo flow cytometry colorectal surgery CellSearch single-cell analysis disseminated tumor cells EasyCount slides microsatellite instability circulating plasma cells circulating leukemia cells ARV7 SLUG androgen receptor metastatic colorectal cancer leukocyte-derived extracellular vesicles prostate cancer (PCa) neutrophils liquid biopsy enzalutamide CD133 enrichment and detection technologies biomarkers immune checkpoint inhibitors biomarker RAD23B microbiome integrin B1 ACCEPT emboli small-cell lung carcinoma EPISPOT microfluidics early breast cancer circulating tumor cells (CTC) tumor-initiating cells (TICs) immunomodulation xenograft models CTC-derived xenografts malaria circulating tumor cells (CTCs) clinical utility exosomes liquid surgery ctRNA CTCs epithelial–mesenchymal transition targeted therapy hematological cells gene expression analysis hepatocellular carcinoma (HCC) breast cancer EpCAM enrichment prostate cancer CTC abiraterone fibronectin CTC-derived ex vivo models CTMat chromogranin A CTM exosome thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 n/a FOLFIRINOX immunofluorescence imaging AR-V7 circulating tumour cells chemoradioresistance CTC-based treatment decisions rVAR2 immunophenotyping immune system CellSearch® flow cytometry clinical trials circulating tumor DNA synaptophysin stem cells colorectal cancer melanoma CTC biology platelets AR CTC capture technology castration resistant prostate cancer (CRPC) PD-L1 expression rovalpituzumab tesirine HMB-45 thymidylate synthase ctDNA tumor cell dissemination solid cancers metastasis locally advanced rectal cancer miRNA epithelial-to-mesenchymal transition (EMT) NSCLC tumor biomarkers tumor stem cells circulating tumor cells major histocompatibility complex class I (MHCI) bone marrow heterogeneity cerebrospinal liquid biopsy fish glioma in vivo flow cytometry colorectal surgery CellSearch single-cell analysis disseminated tumor cells EasyCount slides microsatellite instability circulating plasma cells circulating leukemia cells ARV7 SLUG androgen receptor metastatic colorectal cancer leukocyte-derived extracellular vesicles prostate cancer (PCa) neutrophils liquid biopsy enzalutamide CD133 enrichment and detection technologies biomarkers immune checkpoint inhibitors biomarker RAD23B microbiome integrin B1 ACCEPT emboli small-cell lung carcinoma EPISPOT microfluidics early breast cancer circulating tumor cells (CTC) tumor-initiating cells (TICs) immunomodulation xenograft models CTC-derived xenografts malaria circulating tumor cells (CTCs) clinical utility exosomes liquid surgery ctRNA CTCs epithelial–mesenchymal transition targeted therapy hematological cells gene expression analysis hepatocellular carcinoma (HCC) breast cancer EpCAM enrichment prostate cancer CTC abiraterone fibronectin CTC-derived ex vivo models CTMat chromogranin A CTM exosome thema EDItEUR::M Medicine and Nursing |
| url | 45989 |
| work_keys_str_mv | AT alixpanabierescatherine circulatingtumorcellsfindingrareeventsforahugeknowledgeofcancerdissemination |