Cognitive deficits in schizophrenia and other neuropsychiatric disorders: Convergence of preclinical and clinical evidence
Neuropsychiatric diseases, such as schizophrenia, Alzheimer's disease, and etc., represent a serious medical and socioeconomic problems. These diseases are often accompanied by impairments of cognitive function, e.g., abstract thinking, decision-making, attention, and several types of memory. Such d...
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| Հիմնական հեղինակներ: | , |
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| Ձևաչափ: | Online |
| Լեզու: | անգլերեն |
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Frontiers Media SA
2021
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| Առցանց հասանելիություն: | 19575 |
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| _version_ | 1869521382306480128 |
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| author | Ales Stuchlik Tomiki Sumiyoshi |
| author_browse | Ales Stuchlik Tomiki Sumiyoshi |
| author_facet | Ales Stuchlik Tomiki Sumiyoshi |
| author_sort | Ales Stuchlik |
| collection | Directory of Open Access Books |
| description | Neuropsychiatric diseases, such as schizophrenia, Alzheimer's disease, and etc., represent a serious medical and socioeconomic problems. These diseases are often accompanied by impairments of cognitive function, e.g., abstract thinking, decision-making, attention, and several types of memory. Such deficits significantly disrupt quality of life and daily functioning of patients. Cognitive deficits in neuropsychiatric diseases are associated with alterations of brain morphology and function, and are often resistant to therapeutic interventions. In schizophrenia and related disorders, cognitive deficits are also defined as endophenotypes, i.e. measurable phenotypes linking these disaeses with discrete heritable and reproducible traits. This points to the importance of elucidating these endophenotypes in translational studies. Animal models may not mimic the full spectrum of clinical symptoms, but may act as analogies of particular behaviors or other pathological outcomes. They are useful to search for the etiology of particular psychiatric illnesses and novel therapeutics. Moreover, several behavioral tests to measure cognitive performance in rodents and other species have been implemented. The primary focus of the present topic is to provide up-to-date information on cognitive deficits of neuropsychiatric disorders, such as schizophrenia. This Research Topic also delineates future directions for translational studies aimed at developing novel treatments/interventions of cognitive disturbances. |
| format | Online |
| id | doab-20.500.12854ir-43471 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-434712024-04-05T12:36:14Z Cognitive deficits in schizophrenia and other neuropsychiatric disorders: Convergence of preclinical and clinical evidence Ales Stuchlik Tomiki Sumiyoshi RC321-571 Q1-390 Learning Neurology cognitive deficits Memory neuropsychiatric disorders Cognition translation research animal model Psychiatry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Neuropsychiatric diseases, such as schizophrenia, Alzheimer's disease, and etc., represent a serious medical and socioeconomic problems. These diseases are often accompanied by impairments of cognitive function, e.g., abstract thinking, decision-making, attention, and several types of memory. Such deficits significantly disrupt quality of life and daily functioning of patients. Cognitive deficits in neuropsychiatric diseases are associated with alterations of brain morphology and function, and are often resistant to therapeutic interventions. In schizophrenia and related disorders, cognitive deficits are also defined as endophenotypes, i.e. measurable phenotypes linking these disaeses with discrete heritable and reproducible traits. This points to the importance of elucidating these endophenotypes in translational studies. Animal models may not mimic the full spectrum of clinical symptoms, but may act as analogies of particular behaviors or other pathological outcomes. They are useful to search for the etiology of particular psychiatric illnesses and novel therapeutics. Moreover, several behavioral tests to measure cognitive performance in rodents and other species have been implemented. The primary focus of the present topic is to provide up-to-date information on cognitive deficits of neuropsychiatric disorders, such as schizophrenia. This Research Topic also delineates future directions for translational studies aimed at developing novel treatments/interventions of cognitive disturbances. 2021-02-11T10:05:39Z 2021-02-11T10:05:39Z 2016-08-16 10:34:25 2015 book 19575 16648714 9782889196791 https://directory.doabooks.org/handle/20.500.12854/43471 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Cognitive_deficits_in_schizophrenia_and_other_neuropsychiatric_disorders_Convergence_of_preclinical/707 http://journal.frontiersin.org/researchtopic/1370/cognitive-deficits-in-schizophrenia-and-other-neuropsychiatric-disorders-convergence-of-preclinical Frontiers Media SA 10.3389/978-2-88919-679-1 10.3389/978-2-88919-679-1 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889196791 283 open access |
| spellingShingle | RC321-571 Q1-390 Learning Neurology cognitive deficits Memory neuropsychiatric disorders Cognition translation research animal model Psychiatry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Ales Stuchlik Tomiki Sumiyoshi Cognitive deficits in schizophrenia and other neuropsychiatric disorders: Convergence of preclinical and clinical evidence |
| title | Cognitive deficits in schizophrenia and other neuropsychiatric disorders: Convergence of preclinical and clinical evidence |
| title_full | Cognitive deficits in schizophrenia and other neuropsychiatric disorders: Convergence of preclinical and clinical evidence |
| title_fullStr | Cognitive deficits in schizophrenia and other neuropsychiatric disorders: Convergence of preclinical and clinical evidence |
| title_full_unstemmed | Cognitive deficits in schizophrenia and other neuropsychiatric disorders: Convergence of preclinical and clinical evidence |
| title_short | Cognitive deficits in schizophrenia and other neuropsychiatric disorders: Convergence of preclinical and clinical evidence |
| title_sort | cognitive deficits in schizophrenia and other neuropsychiatric disorders convergence of preclinical and clinical evidence |
| topic | RC321-571 Q1-390 Learning Neurology cognitive deficits Memory neuropsychiatric disorders Cognition translation research animal model Psychiatry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 Learning Neurology cognitive deficits Memory neuropsychiatric disorders Cognition translation research animal model Psychiatry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 19575 |
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