The Coming of Age of Insulin-Signalling in Insects
The new millennium has seen a major paradigm shift in insect endocrinology. Great advancements are being made which establish that nutrition and growth play a central role in diverse cellular and physiological phenomena during insect development and reproduction. Nutrition affects rates of growth an...
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| Główni autorzy: | , |
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| Format: | Online |
| Język: | angielski |
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Frontiers Media SA
2021
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| Dostęp online: | 18576 |
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| _version_ | 1869522941573595136 |
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| author | Colin G.H. Steel Xanthe Vafopoulou |
| author_browse | Colin G.H. Steel Xanthe Vafopoulou |
| author_facet | Colin G.H. Steel Xanthe Vafopoulou |
| author_sort | Colin G.H. Steel |
| collection | Directory of Open Access Books |
| description | The new millennium has seen a major paradigm shift in insect endocrinology. Great advancements are being made which establish that nutrition and growth play a central role in diverse cellular and physiological phenomena during insect development and reproduction. Nutrition affects rates of growth and is mainly regulated by the function of the pathway of insulin/insulin-like growth factor signalling. This pathway is highly conserved across species and ultimately regulates rates of cell growth and proliferation in growing organs. Insulin and insulin-like peptides (ILPs) are some of the best studied hormones in the animal kingdom and all share a common structural motif and initiate a wide range of closely similar physiological processes in higher organisms. In insects, nutrition, via circulating sugar, promotes release of ILPs from brain neurosecretory cells into the haemolymph, which act on peripheral tissues and stimulate protein synthesis and cell growth. Therefore, insect ILPs are common mediators between nutrition and growth in insects and are functionally analogous to mammalian insulin. The 1980s and 1990s witnessed great progress in elucidation of the physiological and molecular mechanism of action of numerous insect hormones involved in regulation of growth, development, reproduction and metabolism. But the signals for the initiation or termination of controlled events remained largely unknown. ILPs were first identified from the silkmoth Bombyx mori and were named bombyxins, but related peptides were soon found in numerous species and their functions elucidated. The insulin signalling pathway is now recognized as a central factor in the timing of cell proliferation, growth, longevity, reproduction, and reproductive diapause, as well as social behaviour. Recent work has revealed that the insulin signalling pathway is closely integrated with that of various other hormones, including ecdysteroids, the juvenile hormones and neuropeptide(s) such a prothoracicotropic hormone. In addition, the pathway is also linked with both circadian (daily) and photoperiodic (seasonal) clocks potentially providing a basis for its timing function. This Research Topic aims to provide the only current collection of recent advances on insect ILPs. We encouraged submissions on all areas related to identification, characterization, regulation and physiological functions of insect ILPs. We welcomed both full and short reviews and original research articles. |
| format | Online |
| id | doab-20.500.12854ir-43556 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-435562024-03-31T22:45:11Z The Coming of Age of Insulin-Signalling in Insects Colin G.H. Steel Xanthe Vafopoulou QP1-981 Q1-390 insulin-like proteins timekeeping interactions of signaling pathways nutrition and metabolism Growth and Development thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology The new millennium has seen a major paradigm shift in insect endocrinology. Great advancements are being made which establish that nutrition and growth play a central role in diverse cellular and physiological phenomena during insect development and reproduction. Nutrition affects rates of growth and is mainly regulated by the function of the pathway of insulin/insulin-like growth factor signalling. This pathway is highly conserved across species and ultimately regulates rates of cell growth and proliferation in growing organs. Insulin and insulin-like peptides (ILPs) are some of the best studied hormones in the animal kingdom and all share a common structural motif and initiate a wide range of closely similar physiological processes in higher organisms. In insects, nutrition, via circulating sugar, promotes release of ILPs from brain neurosecretory cells into the haemolymph, which act on peripheral tissues and stimulate protein synthesis and cell growth. Therefore, insect ILPs are common mediators between nutrition and growth in insects and are functionally analogous to mammalian insulin. The 1980s and 1990s witnessed great progress in elucidation of the physiological and molecular mechanism of action of numerous insect hormones involved in regulation of growth, development, reproduction and metabolism. But the signals for the initiation or termination of controlled events remained largely unknown. ILPs were first identified from the silkmoth Bombyx mori and were named bombyxins, but related peptides were soon found in numerous species and their functions elucidated. The insulin signalling pathway is now recognized as a central factor in the timing of cell proliferation, growth, longevity, reproduction, and reproductive diapause, as well as social behaviour. Recent work has revealed that the insulin signalling pathway is closely integrated with that of various other hormones, including ecdysteroids, the juvenile hormones and neuropeptide(s) such a prothoracicotropic hormone. In addition, the pathway is also linked with both circadian (daily) and photoperiodic (seasonal) clocks potentially providing a basis for its timing function. This Research Topic aims to provide the only current collection of recent advances on insect ILPs. We encouraged submissions on all areas related to identification, characterization, regulation and physiological functions of insect ILPs. We welcomed both full and short reviews and original research articles. 2021-02-11T10:10:24Z 2021-02-11T10:10:24Z 2016-02-05 17:24:33 2015 book 18576 16648714 9782889193141 https://directory.doabooks.org/handle/20.500.12854/43556 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/The_Coming_of_Age_of_Insulin-Signalling_in_Insects/424#nogo http://journal.frontiersin.org/researchtopic/1140/the-coming-of-age-of-insulin-signalling-in-insects Frontiers Media SA 10.3389/978-2-88919-314-1 10.3389/978-2-88919-314-1 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889193141 138 open access |
| spellingShingle | QP1-981 Q1-390 insulin-like proteins timekeeping interactions of signaling pathways nutrition and metabolism Growth and Development thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology Colin G.H. Steel Xanthe Vafopoulou The Coming of Age of Insulin-Signalling in Insects |
| title | The Coming of Age of Insulin-Signalling in Insects |
| title_full | The Coming of Age of Insulin-Signalling in Insects |
| title_fullStr | The Coming of Age of Insulin-Signalling in Insects |
| title_full_unstemmed | The Coming of Age of Insulin-Signalling in Insects |
| title_short | The Coming of Age of Insulin-Signalling in Insects |
| title_sort | coming of age of insulin signalling in insects |
| topic | QP1-981 Q1-390 insulin-like proteins timekeeping interactions of signaling pathways nutrition and metabolism Growth and Development thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| topic_facet | QP1-981 Q1-390 insulin-like proteins timekeeping interactions of signaling pathways nutrition and metabolism Growth and Development thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| url | 18576 |
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