Comparative studies between HTLV-1 and HTLV-2 function and pathobiology
Human T-cell leukemia viruses type 1 and 2 (HTLV-1 and HTLV-2) share a common genetic organization, expression strategy and ability to infect and immortalize T-cells in vitro; however, HTLV-1 and HTLV-2 are strikingly different in terms of clinical impact. HTLV-1 is recognized as the aetiological ag...
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| Formáid: | Online |
| Teanga: | Béarla |
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Frontiers Media SA
2021
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| Ábhair: | |
| Rochtain ar líne: | 17686 |
| Clibeanna: |
Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!
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| _version_ | 1869526127864709120 |
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| author | Francoise Bex Umberto Bertazzoni |
| author_browse | Francoise Bex Umberto Bertazzoni |
| author_facet | Francoise Bex Umberto Bertazzoni |
| author_sort | Francoise Bex |
| collection | Directory of Open Access Books |
| description | Human T-cell leukemia viruses type 1 and 2 (HTLV-1 and HTLV-2) share a common genetic organization, expression strategy and ability to infect and immortalize T-cells in vitro; however, HTLV-1 and HTLV-2 are strikingly different in terms of clinical impact. HTLV-1 is recognized as the aetiological agent of adult T-cell leukemia/lymphoma (ATLL), and HTLV-associated myeolopathy/tropical spastic paraparesis (HAM/TSP), in contrast, HTLV-2 does not cause hematologic disorders and is only sporadically associated with cases of subacute myelopathy. HTLV-1 and HTLV-2 also exhibit distinct cellular tropisms in vivo: HTLV-1 is mainly found in CD4+T lymphocytes, whereas CD8+T-cells are the preferred target for HTLV-2. The articles contributed in this Research Topic are covering all the different aspects that characterize HTLV-1 and HTLV-2, by highlighting differences in their biology that might provide clues to their distinct pathogenic properties. |
| format | Online |
| id | doab-20.500.12854ir-43627 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-436272024-04-05T17:31:04Z Comparative studies between HTLV-1 and HTLV-2 function and pathobiology Francoise Bex Umberto Bertazzoni QR1-502 Q1-390 Proteins Co-infection Expression HTLV-1 HTLV-2 thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) Human T-cell leukemia viruses type 1 and 2 (HTLV-1 and HTLV-2) share a common genetic organization, expression strategy and ability to infect and immortalize T-cells in vitro; however, HTLV-1 and HTLV-2 are strikingly different in terms of clinical impact. HTLV-1 is recognized as the aetiological agent of adult T-cell leukemia/lymphoma (ATLL), and HTLV-associated myeolopathy/tropical spastic paraparesis (HAM/TSP), in contrast, HTLV-2 does not cause hematologic disorders and is only sporadically associated with cases of subacute myelopathy. HTLV-1 and HTLV-2 also exhibit distinct cellular tropisms in vivo: HTLV-1 is mainly found in CD4+T lymphocytes, whereas CD8+T-cells are the preferred target for HTLV-2. The articles contributed in this Research Topic are covering all the different aspects that characterize HTLV-1 and HTLV-2, by highlighting differences in their biology that might provide clues to their distinct pathogenic properties. 2021-02-11T10:14:48Z 2021-02-11T10:14:48Z 2015-11-16 15:44:59 2015 book 17686 16648714 9782889194988 https://directory.doabooks.org/handle/20.500.12854/43627 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Comparative_studies_between_HTLV-1_and_HTLV-2_function_and_pathobiology/529 http://journal.frontiersin.org/researchtopic/1265/comparative-studies-between-htlv-1-and-htlv-2-function-and-pathobiology Frontiers Media SA 10.3389/978-2-88919-498-8 10.3389/978-2-88919-498-8 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889194988 94 open access |
| spellingShingle | QR1-502 Q1-390 Proteins Co-infection Expression HTLV-1 HTLV-2 thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) Francoise Bex Umberto Bertazzoni Comparative studies between HTLV-1 and HTLV-2 function and pathobiology |
| title | Comparative studies between HTLV-1 and HTLV-2 function and pathobiology |
| title_full | Comparative studies between HTLV-1 and HTLV-2 function and pathobiology |
| title_fullStr | Comparative studies between HTLV-1 and HTLV-2 function and pathobiology |
| title_full_unstemmed | Comparative studies between HTLV-1 and HTLV-2 function and pathobiology |
| title_short | Comparative studies between HTLV-1 and HTLV-2 function and pathobiology |
| title_sort | comparative studies between htlv 1 and htlv 2 function and pathobiology |
| topic | QR1-502 Q1-390 Proteins Co-infection Expression HTLV-1 HTLV-2 thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) |
| topic_facet | QR1-502 Q1-390 Proteins Co-infection Expression HTLV-1 HTLV-2 thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) |
| url | 17686 |
| work_keys_str_mv | AT francoisebex comparativestudiesbetweenhtlv1andhtlv2functionandpathobiology AT umbertobertazzoni comparativestudiesbetweenhtlv1andhtlv2functionandpathobiology |