Data-Based Radiation Oncology - Design of Clinical Trials
In radiation oncology as in many other specialties clinical trials are essential to investigate new therapy approaches. Usually, preparation for a prospective clinical trial is extremely time consuming until ethics approval is obtained. To test a new treatment usually many years pass before it can b...
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| Materiálatiipa: | Online |
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Frontiers Media SA
2021
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| Liŋkkat: | 29667 |
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| author | S Kerstin A. Kessel Fridtjof Nuesslin Bhadrasain Vikram Anne W. Lee Stephanie E. Combs |
| author_browse | Anne W. Lee Bhadrasain Vikram Fridtjof Nuesslin Kerstin A. Kessel S Stephanie E. Combs |
| author_facet | S Kerstin A. Kessel Fridtjof Nuesslin Bhadrasain Vikram Anne W. Lee Stephanie E. Combs |
| author_sort | S |
| collection | Directory of Open Access Books |
| description | In radiation oncology as in many other specialties clinical trials are essential to investigate new therapy approaches. Usually, preparation for a prospective clinical trial is extremely time consuming until ethics approval is obtained. To test a new treatment usually many years pass before it can be implemented in the routine care. During that time, already new interventions emerge, new drugs appear on the market, technical & physical innovations are being implemented, novel biology driven concepts are translated into clinical approaches while we are still investigating the ones from years ago. Another problem is associated with molecular diagnostics and the growing amount of tumor specific biomarkers which allows for a better stratification of patient subgroups. On the other side, this may result in a much longer time for patient recruiting and consequently in larger multicenter trials. Moreover, all of the relevant data must be readily available for treatment decision making, treatment as well as follow-up, and ultimately for trial evaluation. This challenges even more for agreed standards in data acquisition, quality and management. How could we change the way currently clinical trials are performed in a way they are safe and ethically justifiable and speed up the initiation process, so we can provide new and better treatments faster for our patients? Further, while we rely on various quantitative information handling distributed, large heterogeneous amounts of data efficiently is very important. Thus data management becomes a strong focus. A good infrastructure helps to plan, tailor and conduct clinical trials in a way they are easy and quickly analyzable. In this research topic we want to discuss new ideas for intelligent trial designs and concepts for data management. |
| format | Online |
| id | doab-20.500.12854ir-44556 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-445562024-03-30T23:21:47Z Data-Based Radiation Oncology - Design of Clinical Trials S Kerstin A. Kessel Fridtjof Nuesslin Bhadrasain Vikram Anne W. Lee Stephanie E. Combs R5-920 RC254-282 Study Management Clinical trials Data Collection Radiation Oncology Clinical Study design thema EDItEUR::M Medicine and Nursing In radiation oncology as in many other specialties clinical trials are essential to investigate new therapy approaches. Usually, preparation for a prospective clinical trial is extremely time consuming until ethics approval is obtained. To test a new treatment usually many years pass before it can be implemented in the routine care. During that time, already new interventions emerge, new drugs appear on the market, technical & physical innovations are being implemented, novel biology driven concepts are translated into clinical approaches while we are still investigating the ones from years ago. Another problem is associated with molecular diagnostics and the growing amount of tumor specific biomarkers which allows for a better stratification of patient subgroups. On the other side, this may result in a much longer time for patient recruiting and consequently in larger multicenter trials. Moreover, all of the relevant data must be readily available for treatment decision making, treatment as well as follow-up, and ultimately for trial evaluation. This challenges even more for agreed standards in data acquisition, quality and management. How could we change the way currently clinical trials are performed in a way they are safe and ethically justifiable and speed up the initiation process, so we can provide new and better treatments faster for our patients? Further, while we rely on various quantitative information handling distributed, large heterogeneous amounts of data efficiently is very important. Thus data management becomes a strong focus. A good infrastructure helps to plan, tailor and conduct clinical trials in a way they are easy and quickly analyzable. In this research topic we want to discuss new ideas for intelligent trial designs and concepts for data management. 2021-02-11T10:59:10Z 2021-02-11T10:59:10Z 2018-11-16 17:17:57 2018 book 29667 16648714 9782889454389 https://directory.doabooks.org/handle/20.500.12854/44556 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/4727/data-based-radiation-oncology---design-of-clinical-trials Frontiers Media SA 10.3389/978-2-88945-438-9 10.3389/978-2-88945-438-9 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889454389 109 open access |
| spellingShingle | R5-920 RC254-282 Study Management Clinical trials Data Collection Radiation Oncology Clinical Study design thema EDItEUR::M Medicine and Nursing S Kerstin A. Kessel Fridtjof Nuesslin Bhadrasain Vikram Anne W. Lee Stephanie E. Combs Data-Based Radiation Oncology - Design of Clinical Trials |
| title | Data-Based Radiation Oncology - Design of Clinical Trials |
| title_full | Data-Based Radiation Oncology - Design of Clinical Trials |
| title_fullStr | Data-Based Radiation Oncology - Design of Clinical Trials |
| title_full_unstemmed | Data-Based Radiation Oncology - Design of Clinical Trials |
| title_short | Data-Based Radiation Oncology - Design of Clinical Trials |
| title_sort | data based radiation oncology design of clinical trials |
| topic | R5-920 RC254-282 Study Management Clinical trials Data Collection Radiation Oncology Clinical Study design thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC254-282 Study Management Clinical trials Data Collection Radiation Oncology Clinical Study design thema EDItEUR::M Medicine and Nursing |
| url | 29667 |
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