Dendritic Cell Control of Immune Responses
Dendritic cells (DC) are among the first cells to encounter pathogens and damage in peripheral tissues and, upon activation, DC migrate to lymph nodes where they activate and educate T cells to initiate and shape the immune response. DC present pathogen-derived antigen to T cells and drive T cell di...
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| Main Authors: | , |
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| Formato: | Online |
| Idioma: | inglés |
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Frontiers Media SA
2021
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| Subjects: | |
| Acceso en liña: | 18255 |
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| _version_ | 1869521677429243904 |
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| author | Lisa Helene Butterfield Penelope Anne Morel |
| author_browse | Lisa Helene Butterfield Penelope Anne Morel |
| author_facet | Lisa Helene Butterfield Penelope Anne Morel |
| author_sort | Lisa Helene Butterfield |
| collection | Directory of Open Access Books |
| description | Dendritic cells (DC) are among the first cells to encounter pathogens and damage in peripheral tissues and, upon activation, DC migrate to lymph nodes where they activate and educate T cells to initiate and shape the immune response. DC present pathogen-derived antigen to T cells and drive T cell differentiation into particular effector cells through the expression and secretion of co-stimulatory molecules and cytokines respectively. The study of DC biology has included the identification of multiple DC subsets in tissues and lymphoid organs, the differentiation and plasticity of DC subsets, the functional consequences of DC interaction with pathogen, control of DC migratory properties and the impact of DC on T cell activation and differentiation. In recent years sophisticated systems biology approaches have been developed to deepen our understanding of DC function. These studies have identified differences between DC subsets located in various tissues and critical factors that drive the outcome of the interaction between DC and T cells. DC are currently being used in in various clinical therapeutic settings, including as vaccines for cancer and autoimmune disease. A clear understanding of DC factors that contribute to specific immune responses is vital to the success of DC based therapies. This research topic will give a comprehensive overview of current issues in DC biology and provides an update on the clinical uses of DC in the therapy of autoimmunity and cancer. |
| format | Online |
| id | doab-20.500.12854ir-44725 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-447252024-03-30T23:22:53Z Dendritic Cell Control of Immune Responses Lisa Helene Butterfield Penelope Anne Morel R5-920 RC581-607 Autoimmunity Dendritic Cells Immune Regulation T cells Cancer thema EDItEUR::M Medicine and Nursing Dendritic cells (DC) are among the first cells to encounter pathogens and damage in peripheral tissues and, upon activation, DC migrate to lymph nodes where they activate and educate T cells to initiate and shape the immune response. DC present pathogen-derived antigen to T cells and drive T cell differentiation into particular effector cells through the expression and secretion of co-stimulatory molecules and cytokines respectively. The study of DC biology has included the identification of multiple DC subsets in tissues and lymphoid organs, the differentiation and plasticity of DC subsets, the functional consequences of DC interaction with pathogen, control of DC migratory properties and the impact of DC on T cell activation and differentiation. In recent years sophisticated systems biology approaches have been developed to deepen our understanding of DC function. These studies have identified differences between DC subsets located in various tissues and critical factors that drive the outcome of the interaction between DC and T cells. DC are currently being used in in various clinical therapeutic settings, including as vaccines for cancer and autoimmune disease. A clear understanding of DC factors that contribute to specific immune responses is vital to the success of DC based therapies. This research topic will give a comprehensive overview of current issues in DC biology and provides an update on the clinical uses of DC in the therapy of autoimmunity and cancer. 2021-02-11T11:07:49Z 2021-02-11T11:07:49Z 2016-01-19 14:05:46 2016 book 18255 16648714 9782889198689 https://directory.doabooks.org/handle/20.500.12854/44725 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Dendritic_Cell_Control_of_Immune_Responses/935 http://journal.frontiersin.org/researchtopic/1458/dendritic-cell-control-of-immune-responses Frontiers Media SA 10.3389/978-2-88919-868-9 10.3389/978-2-88919-868-9 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889198689 121 open access |
| spellingShingle | R5-920 RC581-607 Autoimmunity Dendritic Cells Immune Regulation T cells Cancer thema EDItEUR::M Medicine and Nursing Lisa Helene Butterfield Penelope Anne Morel Dendritic Cell Control of Immune Responses |
| title | Dendritic Cell Control of Immune Responses |
| title_full | Dendritic Cell Control of Immune Responses |
| title_fullStr | Dendritic Cell Control of Immune Responses |
| title_full_unstemmed | Dendritic Cell Control of Immune Responses |
| title_short | Dendritic Cell Control of Immune Responses |
| title_sort | dendritic cell control of immune responses |
| topic | R5-920 RC581-607 Autoimmunity Dendritic Cells Immune Regulation T cells Cancer thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC581-607 Autoimmunity Dendritic Cells Immune Regulation T cells Cancer thema EDItEUR::M Medicine and Nursing |
| url | 18255 |
| work_keys_str_mv | AT lisahelenebutterfield dendriticcellcontrolofimmuneresponses AT penelopeannemorel dendriticcellcontrolofimmuneresponses |