Dendritic spines: From shape to function
One fundamental requisite for a comprehensive view on brain function and cognition is the understanding of the neuronal network activity of the brain. Neurons are organized into complex networks, interconnected through synapses. The main sites for excitatory synapses in the brain are thin protrusion...
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| Formatua: | Online |
| Hizkuntza: | ingelesa |
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Frontiers Media SA
2021
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| Sarrera elektronikoa: | 18885 |
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| _version_ | 1869516394925654016 |
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| author | Nicolas Heck Ruth Benavides-Piccione |
| author_browse | Nicolas Heck Ruth Benavides-Piccione |
| author_facet | Nicolas Heck Ruth Benavides-Piccione |
| author_sort | Nicolas Heck |
| collection | Directory of Open Access Books |
| description | One fundamental requisite for a comprehensive view on brain function and cognition is the understanding of the neuronal network activity of the brain. Neurons are organized into complex networks, interconnected through synapses. The main sites for excitatory synapses in the brain are thin protrusions called dendritic spines that emerge from dendrites. Dendritic spines have a distinct morphology with a specific molecular organization. They are considered as subcellular compartments that constrain diffusion and influence signal processing by the neuron and, hence, spines are functional integrative units for which morphology and function are tightly coupled. The density of spines along the dendrite reflects the levels of connectivity within the neuronal network. Furthermore, the relevance of studying dendritic spines is emphasized by the observation that their morphology changes with synaptic plasticity and is altered in many psychiatric disorders. The present Research Topic deals with some of the most recent findings concerning dendritic spine structure and function, showing that, in order to understand how brain neuronal activity operates, these two factors should be regarded as being intrinsically linked. |
| format | Online |
| id | doab-20.500.12854ir-44727 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-447272024-04-05T12:35:37Z Dendritic spines: From shape to function Nicolas Heck Ruth Benavides-Piccione RC321-571 Q1-390 Synaptic integration pyramidal cell Cerebral Cortex Dendrites Synapses thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences One fundamental requisite for a comprehensive view on brain function and cognition is the understanding of the neuronal network activity of the brain. Neurons are organized into complex networks, interconnected through synapses. The main sites for excitatory synapses in the brain are thin protrusions called dendritic spines that emerge from dendrites. Dendritic spines have a distinct morphology with a specific molecular organization. They are considered as subcellular compartments that constrain diffusion and influence signal processing by the neuron and, hence, spines are functional integrative units for which morphology and function are tightly coupled. The density of spines along the dendrite reflects the levels of connectivity within the neuronal network. Furthermore, the relevance of studying dendritic spines is emphasized by the observation that their morphology changes with synaptic plasticity and is altered in many psychiatric disorders. The present Research Topic deals with some of the most recent findings concerning dendritic spine structure and function, showing that, in order to understand how brain neuronal activity operates, these two factors should be regarded as being intrinsically linked. 2021-02-11T11:07:52Z 2021-02-11T11:07:52Z 2016-04-07 11:22:02 2016 book 18885 16648714 9782889197668 https://directory.doabooks.org/handle/20.500.12854/44727 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Dendritic_Spines_From_Shape_to_Function/811 http://journal.frontiersin.org/researchtopic/1533/dendritic-spines-from-shape-to-function Frontiers Media SA 10.3389/978-2-88919-766-8 10.3389/978-2-88919-766-8 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889197668 235 open access |
| spellingShingle | RC321-571 Q1-390 Synaptic integration pyramidal cell Cerebral Cortex Dendrites Synapses thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Nicolas Heck Ruth Benavides-Piccione Dendritic spines: From shape to function |
| title | Dendritic spines: From shape to function |
| title_full | Dendritic spines: From shape to function |
| title_fullStr | Dendritic spines: From shape to function |
| title_full_unstemmed | Dendritic spines: From shape to function |
| title_short | Dendritic spines: From shape to function |
| title_sort | dendritic spines from shape to function |
| topic | RC321-571 Q1-390 Synaptic integration pyramidal cell Cerebral Cortex Dendrites Synapses thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 Synaptic integration pyramidal cell Cerebral Cortex Dendrites Synapses thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 18885 |
| work_keys_str_mv | AT nicolasheck dendriticspinesfromshapetofunction AT ruthbenavidespiccione dendriticspinesfromshapetofunction |