Dental and Periodontal Tissues Formation and Regeneration: Current Approaches and Future Challenges
Sequential and reciprocal interactions between oral epithelial and cranial neural crest-derived mesenchymal cells give rise to the teeth and periodontium. Teeth are vital organs containing a rich number of blood vessels and nerve fibers within the dental pulp and periodontium. Teeth are composed by...
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| Format: | Online |
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Frontiers Media SA
2021
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| Online dostop: | 18371 |
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| _version_ | 1869521382460620800 |
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| author | Thimios Mitsiadis Giovanna Orsini Victor E. Arana-Chavez |
| author_browse | Giovanna Orsini Thimios Mitsiadis Victor E. Arana-Chavez |
| author_facet | Thimios Mitsiadis Giovanna Orsini Victor E. Arana-Chavez |
| author_sort | Thimios Mitsiadis |
| collection | Directory of Open Access Books |
| description | Sequential and reciprocal interactions between oral epithelial and cranial neural crest-derived mesenchymal cells give rise to the teeth and periodontium. Teeth are vital organs containing a rich number of blood vessels and nerve fibers within the dental pulp and periodontium. Teeth are composed by unique and specific collagenous (dentin, fibrillar cementum) and non-collagenous (enamel) highly mineralized extracellular matrices. Alveolar bone is another collagenous hard tissue that supports tooth stability and function through its close interaction with the periodontal ligament. Dental hard tissues are often damaged after infection or traumatic injuries that lead to the partial or complete destruction of the functional dental and supportive tissues. Well-established protocols are routinely used in dental clinics for the restoration or replacement of the damaged tooth and alveolar bone areas. Recent progress in the fields of cell biology, tissue engineering, and nanotechnology offers promising opportunities to repair damaged or missing dental tissues. Indeed, pulp and periodontal tissue regeneration is progressing rapidly with the application of stem cells, biodegradable scaffolds, and growth factors. Furthermore, methods that enable partial dental hard tissue repair and regeneration are being evaluated with variable degrees of success. However, these cell-based therapies are still incipient and many issues need to be addressed before any clinical application. The understanding of tooth and periodontal tissues formation would be beneficial for improving regenerative attempts in dental clinics. In the present e-book we have covered the various aspects dealing with dental and periodontal tissues physiology and regeneration in 6 chapters: 1. General principles on the use of stem cells for regenerating craniofacial and dental tissues 2. The roles of nerves, vessels and stem cell niches in tissue regeneration 3. Dental pulp regeneration and mechanisms of various odontoblast functions 4. Dental root and periodontal physiology, pathology and regeneration 5. Physiology and regeneration of the bone using various scaffolds and stem cell populations 6. Physiology, pathology and regeneration of enamel using dental epithelial stem cells |
| format | Online |
| id | doab-20.500.12854ir-44741 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-447412024-03-31T22:45:09Z Dental and Periodontal Tissues Formation and Regeneration: Current Approaches and Future Challenges Thimios Mitsiadis Giovanna Orsini Victor E. Arana-Chavez QP1-981 Q1-390 Stem Cells vasculature Regenerative dentistry scaffolds Periodontium enamel Tooth innervation Dental Pulp Tissue Engineering thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology Sequential and reciprocal interactions between oral epithelial and cranial neural crest-derived mesenchymal cells give rise to the teeth and periodontium. Teeth are vital organs containing a rich number of blood vessels and nerve fibers within the dental pulp and periodontium. Teeth are composed by unique and specific collagenous (dentin, fibrillar cementum) and non-collagenous (enamel) highly mineralized extracellular matrices. Alveolar bone is another collagenous hard tissue that supports tooth stability and function through its close interaction with the periodontal ligament. Dental hard tissues are often damaged after infection or traumatic injuries that lead to the partial or complete destruction of the functional dental and supportive tissues. Well-established protocols are routinely used in dental clinics for the restoration or replacement of the damaged tooth and alveolar bone areas. Recent progress in the fields of cell biology, tissue engineering, and nanotechnology offers promising opportunities to repair damaged or missing dental tissues. Indeed, pulp and periodontal tissue regeneration is progressing rapidly with the application of stem cells, biodegradable scaffolds, and growth factors. Furthermore, methods that enable partial dental hard tissue repair and regeneration are being evaluated with variable degrees of success. However, these cell-based therapies are still incipient and many issues need to be addressed before any clinical application. The understanding of tooth and periodontal tissues formation would be beneficial for improving regenerative attempts in dental clinics. In the present e-book we have covered the various aspects dealing with dental and periodontal tissues physiology and regeneration in 6 chapters: 1. General principles on the use of stem cells for regenerating craniofacial and dental tissues 2. The roles of nerves, vessels and stem cell niches in tissue regeneration 3. Dental pulp regeneration and mechanisms of various odontoblast functions 4. Dental root and periodontal physiology, pathology and regeneration 5. Physiology and regeneration of the bone using various scaffolds and stem cell populations 6. Physiology, pathology and regeneration of enamel using dental epithelial stem cells 2021-02-11T11:08:25Z 2021-02-11T11:08:25Z 2016-01-19 14:05:46 2016 book 18371 16648714 9782889199846 https://directory.doabooks.org/handle/20.500.12854/44741 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Dental_and_Periodontal_Tissues_Formation_and_Regeneration_Current_Approaches_and_Future_Challenges/1020#nogo http://journal.frontiersin.org/researchtopic/3533/dental-and-periodontal-tissues-formation-and-regeneration-current-approaches-and-future-challenges Frontiers Media SA 10.3389/978-2-88919-984-6 10.3389/978-2-88919-984-6 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889199846 246 open access |
| spellingShingle | QP1-981 Q1-390 Stem Cells vasculature Regenerative dentistry scaffolds Periodontium enamel Tooth innervation Dental Pulp Tissue Engineering thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology Thimios Mitsiadis Giovanna Orsini Victor E. Arana-Chavez Dental and Periodontal Tissues Formation and Regeneration: Current Approaches and Future Challenges |
| title | Dental and Periodontal Tissues Formation and Regeneration: Current Approaches and Future Challenges |
| title_full | Dental and Periodontal Tissues Formation and Regeneration: Current Approaches and Future Challenges |
| title_fullStr | Dental and Periodontal Tissues Formation and Regeneration: Current Approaches and Future Challenges |
| title_full_unstemmed | Dental and Periodontal Tissues Formation and Regeneration: Current Approaches and Future Challenges |
| title_short | Dental and Periodontal Tissues Formation and Regeneration: Current Approaches and Future Challenges |
| title_sort | dental and periodontal tissues formation and regeneration current approaches and future challenges |
| topic | QP1-981 Q1-390 Stem Cells vasculature Regenerative dentistry scaffolds Periodontium enamel Tooth innervation Dental Pulp Tissue Engineering thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| topic_facet | QP1-981 Q1-390 Stem Cells vasculature Regenerative dentistry scaffolds Periodontium enamel Tooth innervation Dental Pulp Tissue Engineering thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| url | 18371 |
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