Disease and the Hippo Pathway: Cellular and Molecular Mechanisms
The Hippo pathway is a highly dynamic cellular signaling nexus that plays central roles in multiple cell types and regulates regeneration, metabolism, and development. The Hippo pathway integrates mechanotransduction, cell polarity, inflammation, and numerous types of paracrine signaling. If not tig...
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| Fformat: | Online |
| Iaith: | Saesneg |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Pynciau: | |
| Mynediad Ar-lein: | 42670 |
| Tagiau: |
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!
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| _version_ | 1869515441692475392 |
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| author | Hansen, Carsten Gram |
| author_browse | Hansen, Carsten Gram |
| author_facet | Hansen, Carsten Gram |
| author_sort | Hansen, Carsten Gram |
| collection | Directory of Open Access Books |
| description | The Hippo pathway is a highly dynamic cellular signaling nexus that plays central roles in multiple cell types and regulates regeneration, metabolism, and development. The Hippo pathway integrates mechanotransduction, cell polarity, inflammation, and numerous types of paracrine signaling. If not tightly regulated, dysregulated Hippo pathway signaling drives the onset and progression of a range of diseases, including fibrosis and cancer. The molecular understanding of the Hippo pathway is rapidly evolving. This Special Issue contains ten articles contributed by established and up-and-coming Hippo pathway experts that, as a whole, provides an up-to-date overview of how dysregulated Hippo pathway activity is a common driver of specific diseases. The articles have a particular focus on the underlying molecular and cellular mechanisms that cause the Hippo pathway to go awry, and especially how this drives disease. The articles analyze disease-specific as well as common themes, which provides valuable insights into the fundamental molecular mechanisms in the dysfunctioning Hippo pathway, and thereby offer practical insights into potential future therapeutic intervention strategies. |
| format | Online |
| id | doab-20.500.12854ir-45263 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-452632024-04-05T12:31:51Z Disease and the Hippo Pathway: Cellular and Molecular Mechanisms Hansen, Carsten Gram QH301-705.5 Q1-390 STRIPAK skin cancer n/a Lats2 transcription myofibroblast epigenetic Hippo cancer immunity TAZ Taz TAZ (transcriptional co-activator with PDZ-binding motif) adaptive immunity fibroblasts innate immunity LATS MST (mammalian STE20-like protein kinase) phosphorylation stem cells wound healing signal transduction angiogenesis LATS1/2 EMT protein-protein interactions structure biology Hippo pathway hippo pathway autoimmunity Mps one binder YAP/TAZ GPCR fibrosis MST1/2 YAP (yes-associated protein) YAP Yap protein kinase LATS (large tumor suppressor kinase) peripheral nerve sheath tumor signal cross-talk stem cell skin development STK38 tumorigenesis NDR schwannoma G protein-coupled receptor anti-cancer therapy feedback loops vascular mimicry castration resistance chromatin Hippo signalling ECM MST prostate cancer TEAD cancer zebrafish thema EDItEUR::P Mathematics and Science::PS Biology, life sciences The Hippo pathway is a highly dynamic cellular signaling nexus that plays central roles in multiple cell types and regulates regeneration, metabolism, and development. The Hippo pathway integrates mechanotransduction, cell polarity, inflammation, and numerous types of paracrine signaling. If not tightly regulated, dysregulated Hippo pathway signaling drives the onset and progression of a range of diseases, including fibrosis and cancer. The molecular understanding of the Hippo pathway is rapidly evolving. This Special Issue contains ten articles contributed by established and up-and-coming Hippo pathway experts that, as a whole, provides an up-to-date overview of how dysregulated Hippo pathway activity is a common driver of specific diseases. The articles have a particular focus on the underlying molecular and cellular mechanisms that cause the Hippo pathway to go awry, and especially how this drives disease. The articles analyze disease-specific as well as common themes, which provides valuable insights into the fundamental molecular mechanisms in the dysfunctioning Hippo pathway, and thereby offer practical insights into potential future therapeutic intervention strategies. 2021-02-11T11:33:51Z 2021-02-11T11:33:51Z 2019-12-09 11:49:16 2019 book 42670 9783039217762 9783039217779 https://directory.doabooks.org/handle/20.500.12854/45263 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/1835 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03921-777-9 10.3390/books978-3-03921-777-9 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039217762 9783039217779 226 open access |
| spellingShingle | QH301-705.5 Q1-390 STRIPAK skin cancer n/a Lats2 transcription myofibroblast epigenetic Hippo cancer immunity TAZ Taz TAZ (transcriptional co-activator with PDZ-binding motif) adaptive immunity fibroblasts innate immunity LATS MST (mammalian STE20-like protein kinase) phosphorylation stem cells wound healing signal transduction angiogenesis LATS1/2 EMT protein-protein interactions structure biology Hippo pathway hippo pathway autoimmunity Mps one binder YAP/TAZ GPCR fibrosis MST1/2 YAP (yes-associated protein) YAP Yap protein kinase LATS (large tumor suppressor kinase) peripheral nerve sheath tumor signal cross-talk stem cell skin development STK38 tumorigenesis NDR schwannoma G protein-coupled receptor anti-cancer therapy feedback loops vascular mimicry castration resistance chromatin Hippo signalling ECM MST prostate cancer TEAD cancer zebrafish thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Hansen, Carsten Gram Disease and the Hippo Pathway: Cellular and Molecular Mechanisms |
| title | Disease and the Hippo Pathway: Cellular and Molecular Mechanisms |
| title_full | Disease and the Hippo Pathway: Cellular and Molecular Mechanisms |
| title_fullStr | Disease and the Hippo Pathway: Cellular and Molecular Mechanisms |
| title_full_unstemmed | Disease and the Hippo Pathway: Cellular and Molecular Mechanisms |
| title_short | Disease and the Hippo Pathway: Cellular and Molecular Mechanisms |
| title_sort | disease and the hippo pathway cellular and molecular mechanisms |
| topic | QH301-705.5 Q1-390 STRIPAK skin cancer n/a Lats2 transcription myofibroblast epigenetic Hippo cancer immunity TAZ Taz TAZ (transcriptional co-activator with PDZ-binding motif) adaptive immunity fibroblasts innate immunity LATS MST (mammalian STE20-like protein kinase) phosphorylation stem cells wound healing signal transduction angiogenesis LATS1/2 EMT protein-protein interactions structure biology Hippo pathway hippo pathway autoimmunity Mps one binder YAP/TAZ GPCR fibrosis MST1/2 YAP (yes-associated protein) YAP Yap protein kinase LATS (large tumor suppressor kinase) peripheral nerve sheath tumor signal cross-talk stem cell skin development STK38 tumorigenesis NDR schwannoma G protein-coupled receptor anti-cancer therapy feedback loops vascular mimicry castration resistance chromatin Hippo signalling ECM MST prostate cancer TEAD cancer zebrafish thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | QH301-705.5 Q1-390 STRIPAK skin cancer n/a Lats2 transcription myofibroblast epigenetic Hippo cancer immunity TAZ Taz TAZ (transcriptional co-activator with PDZ-binding motif) adaptive immunity fibroblasts innate immunity LATS MST (mammalian STE20-like protein kinase) phosphorylation stem cells wound healing signal transduction angiogenesis LATS1/2 EMT protein-protein interactions structure biology Hippo pathway hippo pathway autoimmunity Mps one binder YAP/TAZ GPCR fibrosis MST1/2 YAP (yes-associated protein) YAP Yap protein kinase LATS (large tumor suppressor kinase) peripheral nerve sheath tumor signal cross-talk stem cell skin development STK38 tumorigenesis NDR schwannoma G protein-coupled receptor anti-cancer therapy feedback loops vascular mimicry castration resistance chromatin Hippo signalling ECM MST prostate cancer TEAD cancer zebrafish thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | 42670 |
| work_keys_str_mv | AT hansencarstengram diseaseandthehippopathwaycellularandmolecularmechanisms |