Diverse functions of mucosal resident memory T cells
Early studies recognized the unique phenotype and attributes of T cells found in mucosal tissues, such as the intestines, skin, lung and female reproductive tract. This special topic issue will cover many aspects of mucosal-resident T cell biology during infection and disease and is dedicated to Leo...
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| פורמט: | Online |
| שפה: | אנגלית |
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Frontiers Media SA
2021
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| נושאים: | |
| גישה מקוונת: | 18148 |
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אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!
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| _version_ | 1869522255176794112 |
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| author | Kimberly Sue Schluns Kim Klonowski |
| author_browse | Kim Klonowski Kimberly Sue Schluns |
| author_facet | Kimberly Sue Schluns Kim Klonowski |
| author_sort | Kimberly Sue Schluns |
| collection | Directory of Open Access Books |
| description | Early studies recognized the unique phenotype and attributes of T cells found in mucosal tissues, such as the intestines, skin, lung and female reproductive tract. This special topic issue will cover many aspects of mucosal-resident T cell biology during infection and disease and is dedicated to Leo Lefrancois, a pioneer in this field who recently passed away. A major proportion of these mucosal T cells are memory T cells, now recognized as a major constituent of memory T cells referred to as tissue-resident memory T cells. Unlike central and effector memory T cell subsets, tissue-resident memory T cells exhibit tissue specificity with minimal systemic migration. Nonetheless, tissue-resident memory T cells share a similar origin and display some overlapping phenotypes with their other memory T cell counterparts. Articles in this issue will describe the different types of memory T cells residing in mucosal tissues, their origins and functions as well as how they vary among discrete mucosal sites. Manuscripts will consider the unique physiological environments and cellular constituents which facilitate tissue residency while preserving tissue function. Additionally, there will be descriptions of the various mechanisms responsible for the migration and segregation of tissue resident memory CD8 T cells from the peripheral T cell pool. Although the mechanisms facilitating the sequestration of tissue-resident memory T cells within a respective tissue has not well characterized, various theories will also be discussed. Lastly, how these T cells contribute to immunity to pathogens, cancer, and autoimmunity and could be modified through vaccination or therapeutic intervention will be described. As mucosal tissues are the major portals of pathogen entry and frequent transformation, the activities and persistence of tissue resident memory T cells is crucial for mediating protection at these sites. |
| format | Online |
| id | doab-20.500.12854ir-45300 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-453002024-03-30T23:23:00Z Diverse functions of mucosal resident memory T cells Kimberly Sue Schluns Kim Klonowski R5-920 RC581-607 pathogens Microscopy Migration Mucosa T cell differentiation Vaccination Inflammation Epithelium CD103 thema EDItEUR::M Medicine and Nursing Early studies recognized the unique phenotype and attributes of T cells found in mucosal tissues, such as the intestines, skin, lung and female reproductive tract. This special topic issue will cover many aspects of mucosal-resident T cell biology during infection and disease and is dedicated to Leo Lefrancois, a pioneer in this field who recently passed away. A major proportion of these mucosal T cells are memory T cells, now recognized as a major constituent of memory T cells referred to as tissue-resident memory T cells. Unlike central and effector memory T cell subsets, tissue-resident memory T cells exhibit tissue specificity with minimal systemic migration. Nonetheless, tissue-resident memory T cells share a similar origin and display some overlapping phenotypes with their other memory T cell counterparts. Articles in this issue will describe the different types of memory T cells residing in mucosal tissues, their origins and functions as well as how they vary among discrete mucosal sites. Manuscripts will consider the unique physiological environments and cellular constituents which facilitate tissue residency while preserving tissue function. Additionally, there will be descriptions of the various mechanisms responsible for the migration and segregation of tissue resident memory CD8 T cells from the peripheral T cell pool. Although the mechanisms facilitating the sequestration of tissue-resident memory T cells within a respective tissue has not well characterized, various theories will also be discussed. Lastly, how these T cells contribute to immunity to pathogens, cancer, and autoimmunity and could be modified through vaccination or therapeutic intervention will be described. As mucosal tissues are the major portals of pathogen entry and frequent transformation, the activities and persistence of tissue resident memory T cells is crucial for mediating protection at these sites. 2021-02-11T11:36:42Z 2021-02-11T11:36:42Z 2016-01-19 14:05:46 2015 book 18148 16648714 9782889195398 https://directory.doabooks.org/handle/20.500.12854/45300 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://journal.frontiersin.org/researchtopic/2348/diverse-functions-of-mucosal-resident-memory-t-cells http://journal.frontiersin.org/researchtopic/2348/diverse-functions-of-mucosal-resident-memory-t-cells Frontiers Media SA 10.3389/978-2-88919-539-8 10.3389/978-2-88919-539-8 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889195398 86 open access |
| spellingShingle | R5-920 RC581-607 pathogens Microscopy Migration Mucosa T cell differentiation Vaccination Inflammation Epithelium CD103 thema EDItEUR::M Medicine and Nursing Kimberly Sue Schluns Kim Klonowski Diverse functions of mucosal resident memory T cells |
| title | Diverse functions of mucosal resident memory T cells |
| title_full | Diverse functions of mucosal resident memory T cells |
| title_fullStr | Diverse functions of mucosal resident memory T cells |
| title_full_unstemmed | Diverse functions of mucosal resident memory T cells |
| title_short | Diverse functions of mucosal resident memory T cells |
| title_sort | diverse functions of mucosal resident memory t cells |
| topic | R5-920 RC581-607 pathogens Microscopy Migration Mucosa T cell differentiation Vaccination Inflammation Epithelium CD103 thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC581-607 pathogens Microscopy Migration Mucosa T cell differentiation Vaccination Inflammation Epithelium CD103 thema EDItEUR::M Medicine and Nursing |
| url | 18148 |
| work_keys_str_mv | AT kimberlysueschluns diversefunctionsofmucosalresidentmemorytcells AT kimklonowski diversefunctionsofmucosalresidentmemorytcells |