DNA helicases: expression, functions and clinical implications
Helicases are the proteins that bind to double- or single-stranded DNA and/or RNA chains to unwind higher order structures, usually consuming energy from the hydrolysis of ATP molecules. The biological roles of helicases are associated with a variety of DNA and/or RNA metabolisms, including DNA-repl...
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| Autores principales: | , , |
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| Formato: | Online |
| Lenguaje: | inglés |
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Frontiers Media SA
2021
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| Acceso en línea: | 17547 |
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| _version_ | 1869515426654846976 |
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| author | Fumiaki Uchiumi Masayuki Seki Yasuhiro Furuichi |
| author_browse | Fumiaki Uchiumi Masayuki Seki Yasuhiro Furuichi |
| author_facet | Fumiaki Uchiumi Masayuki Seki Yasuhiro Furuichi |
| author_sort | Fumiaki Uchiumi |
| collection | Directory of Open Access Books |
| description | Helicases are the proteins that bind to double- or single-stranded DNA and/or RNA chains to unwind higher order structures, usually consuming energy from the hydrolysis of ATP molecules. The biological roles of helicases are associated with a variety of DNA and/or RNA metabolisms, including DNA-replication, -repair, -recombination, RNA processing, and transcription. Dysfunctions of helicases cause various diseases, such as xeroderma pigmentosum (XP), premature aging syndrome, cancer and immunodeficiency, in humans. Moreover, recent genetic analyses revealed that mutations in helicase-encoding genes are frequently found in patients of specific diseases. Some helicases regulate cellular senescence by controlling integrity of genomes, and others play a role in neuromuscular functions presumably by modulating processing of mRNAs. However, the molecular mechanisms of how helicases are regulated in order to maintain our health are not yet fully understood. In this research topic, we will focus on the expression and functions of helicases and their encoding genes, reviewing recent research progresses that provide new insights into development of clinical and pharmaceutical treatments targeting helicases. |
| format | Online |
| id | doab-20.500.12854ir-45324 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-453242024-04-05T12:34:54Z DNA helicases: expression, functions and clinical implications Fumiaki Uchiumi Masayuki Seki Yasuhiro Furuichi QH426-470 Q1-390 DNA Repair Aging helicases Telomere Cancer thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) Helicases are the proteins that bind to double- or single-stranded DNA and/or RNA chains to unwind higher order structures, usually consuming energy from the hydrolysis of ATP molecules. The biological roles of helicases are associated with a variety of DNA and/or RNA metabolisms, including DNA-replication, -repair, -recombination, RNA processing, and transcription. Dysfunctions of helicases cause various diseases, such as xeroderma pigmentosum (XP), premature aging syndrome, cancer and immunodeficiency, in humans. Moreover, recent genetic analyses revealed that mutations in helicase-encoding genes are frequently found in patients of specific diseases. Some helicases regulate cellular senescence by controlling integrity of genomes, and others play a role in neuromuscular functions presumably by modulating processing of mRNAs. However, the molecular mechanisms of how helicases are regulated in order to maintain our health are not yet fully understood. In this research topic, we will focus on the expression and functions of helicases and their encoding genes, reviewing recent research progresses that provide new insights into development of clinical and pharmaceutical treatments targeting helicases. 2021-02-11T11:37:25Z 2021-02-11T11:37:25Z 2015-10-30 16:33:44 2015 book 17547 16648714 9782889195756 https://directory.doabooks.org/handle/20.500.12854/45324 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/DNA_helicases_expression_functions_and_clinical_implications/599 http://journal.frontiersin.org/researchtopic/2649/dna-helicases-expression-functions-and-clinical-implications Frontiers Media SA 10.3389/978-2-88919-575-6 10.3389/978-2-88919-575-6 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889195756 78 open access |
| spellingShingle | QH426-470 Q1-390 DNA Repair Aging helicases Telomere Cancer thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) Fumiaki Uchiumi Masayuki Seki Yasuhiro Furuichi DNA helicases: expression, functions and clinical implications |
| title | DNA helicases: expression, functions and clinical implications |
| title_full | DNA helicases: expression, functions and clinical implications |
| title_fullStr | DNA helicases: expression, functions and clinical implications |
| title_full_unstemmed | DNA helicases: expression, functions and clinical implications |
| title_short | DNA helicases: expression, functions and clinical implications |
| title_sort | dna helicases expression functions and clinical implications |
| topic | QH426-470 Q1-390 DNA Repair Aging helicases Telomere Cancer thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) |
| topic_facet | QH426-470 Q1-390 DNA Repair Aging helicases Telomere Cancer thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) |
| url | 17547 |
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