DNA Replication Controls
The conditions for DNA replication are not ideal, owing to endogenous and exogenous replication stresses that lead to arrest of the replication fork. Arrested forks are among the most serious threats to genomic integrity because they can break or rearrange, leading to genomic instability, which is a...
保存先:
| 第一著者: | |
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| フォーマット: | Online |
| 言語: | 英語 |
| 出版事項: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
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| 主題: | |
| オンライン･アクセス: | 24922 |
| タグ: |
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| _version_ | 1869528549781667840 |
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| author | Eishi Noguchi (Ed.) |
| author_browse | Eishi Noguchi (Ed.) |
| author_facet | Eishi Noguchi (Ed.) |
| author_sort | Eishi Noguchi (Ed.) |
| collection | Directory of Open Access Books |
| description | The conditions for DNA replication are not ideal, owing to endogenous and exogenous replication stresses that lead to arrest of the replication fork. Arrested forks are among the most serious threats to genomic integrity because they can break or rearrange, leading to genomic instability, which is a hallmark of cancers and aging-related disorders. This title, “DNA Replication Controls”, presents series of new reviews and original research articles, providing a comprehensive guide to theoretical advancements in the field of DNA replication research in both prokaryotic and eukaryotic systems. The topics include DNA polymerases and helicases; replication initiation; replication timing; replication-associated DNA repair; and replication of difficult-to-replicate genomic regions, including telomeres, centromeres and highly-transcribed regions. This title also provides recent advancements in studies of cellular processes that are coordinated with DNA replication and how defects in the DNA replication program result in genetic disorders, including cancer. Written by leading experts in DNA replication regulation, this book will be an important resource for a wide variety of audiences, including junior graduate students and established investigators who have interests in DNA replication and genome maintenance mechanisms. |
| format | Online |
| id | doab-20.500.12854ir-45328 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-453282024-04-05T12:33:28Z DNA Replication Controls Eishi Noguchi (Ed.) QH301-705.5 DNA helicase DNA replication replication stress replication checkpoint DNA polymerase telomere replication cancer genomic instability DNA repair replisome translesion synthesis thema EDItEUR::P Mathematics and Science::PS Biology, life sciences The conditions for DNA replication are not ideal, owing to endogenous and exogenous replication stresses that lead to arrest of the replication fork. Arrested forks are among the most serious threats to genomic integrity because they can break or rearrange, leading to genomic instability, which is a hallmark of cancers and aging-related disorders. This title, “DNA Replication Controls”, presents series of new reviews and original research articles, providing a comprehensive guide to theoretical advancements in the field of DNA replication research in both prokaryotic and eukaryotic systems. The topics include DNA polymerases and helicases; replication initiation; replication timing; replication-associated DNA repair; and replication of difficult-to-replicate genomic regions, including telomeres, centromeres and highly-transcribed regions. This title also provides recent advancements in studies of cellular processes that are coordinated with DNA replication and how defects in the DNA replication program result in genetic disorders, including cancer. Written by leading experts in DNA replication regulation, this book will be an important resource for a wide variety of audiences, including junior graduate students and established investigators who have interests in DNA replication and genome maintenance mechanisms. 2021-02-11T11:37:36Z 2021-02-11T11:37:36Z 2017-12-27 08:38:10 2017 book 24922 9783038425731 9783038425724 https://directory.doabooks.org/handle/20.500.12854/45328 eng image/jpeg Attribution-NonCommercial-NoDerivatives 4.0 International http://www.mdpi.com/books/pdfview/book/454 http://www.mdpi.com/books/pdfview/book/454 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03842-573-1 10.3390/books978-3-03842-573-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783038425731 9783038425724 X, 346 open access |
| spellingShingle | QH301-705.5 DNA helicase DNA replication replication stress replication checkpoint DNA polymerase telomere replication cancer genomic instability DNA repair replisome translesion synthesis thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Eishi Noguchi (Ed.) DNA Replication Controls |
| title | DNA Replication Controls |
| title_full | DNA Replication Controls |
| title_fullStr | DNA Replication Controls |
| title_full_unstemmed | DNA Replication Controls |
| title_short | DNA Replication Controls |
| title_sort | dna replication controls |
| topic | QH301-705.5 DNA helicase DNA replication replication stress replication checkpoint DNA polymerase telomere replication cancer genomic instability DNA repair replisome translesion synthesis thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | QH301-705.5 DNA helicase DNA replication replication stress replication checkpoint DNA polymerase telomere replication cancer genomic instability DNA repair replisome translesion synthesis thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | 24922 |
| work_keys_str_mv | AT eishinoguchied dnareplicationcontrols |