Drug Repositioning: Current Advances and Future Perspectives
Drug repositioning is the process of identifying new indications for existing drugs. At present, the conventional de novo drug discovery process requires an average of about 14 years and US$2.5 billion to approve and launch a drug. Drug repositioning can reduce the time and cost of this process beca...
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| Format: | Online |
| Sprache: | Englisch |
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Frontiers Media SA
2021
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| Online-Zugang: | 32072 |
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| _version_ | 1869514709190836224 |
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| author | Yuhei Nishimura Hideaki Hara |
| author_browse | Hideaki Hara Yuhei Nishimura |
| author_facet | Yuhei Nishimura Hideaki Hara |
| author_sort | Yuhei Nishimura |
| collection | Directory of Open Access Books |
| description | Drug repositioning is the process of identifying new indications for existing drugs. At present, the conventional de novo drug discovery process requires an average of about 14 years and US$2.5 billion to approve and launch a drug. Drug repositioning can reduce the time and cost of this process because it takes advantage of drugs already in clinical use for other indications or drugs that have cleared phase I safety trials but have failed to show efficacy in the intended diseases. Historically, drug repositioning has been realized through serendipitous clinical observations or improved understanding of disease mechanisms. However, recent technological advances have enabled a more systematic approach to drug repositioning. This eBook collects 16 articles from 112 authors, providing readers with current advances and future perspectives of drug repositioning. |
| format | Online |
| id | doab-20.500.12854ir-45510 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-455102024-04-01T14:14:49Z Drug Repositioning: Current Advances and Future Perspectives Yuhei Nishimura Hideaki Hara RM1-950 Q1-390 database Integrative strategies molecular docking polypharmacology multi-omics computational analysis Drug Repositioning data sharing Patenting thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Drug repositioning is the process of identifying new indications for existing drugs. At present, the conventional de novo drug discovery process requires an average of about 14 years and US$2.5 billion to approve and launch a drug. Drug repositioning can reduce the time and cost of this process because it takes advantage of drugs already in clinical use for other indications or drugs that have cleared phase I safety trials but have failed to show efficacy in the intended diseases. Historically, drug repositioning has been realized through serendipitous clinical observations or improved understanding of disease mechanisms. However, recent technological advances have enabled a more systematic approach to drug repositioning. This eBook collects 16 articles from 112 authors, providing readers with current advances and future perspectives of drug repositioning. 2021-02-11T11:49:10Z 2021-02-11T11:49:10Z 2019-01-23 14:53:43 2019 book 32072 16648714 9782889456963 https://directory.doabooks.org/handle/20.500.12854/45510 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/5585/drug-repositioning-current-advances-and-future-perspectives Frontiers Media SA 10.3389/978-2-88945-696-3 10.3389/978-2-88945-696-3 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889456963 153 open access |
| spellingShingle | RM1-950 Q1-390 database Integrative strategies molecular docking polypharmacology multi-omics computational analysis Drug Repositioning data sharing Patenting thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Yuhei Nishimura Hideaki Hara Drug Repositioning: Current Advances and Future Perspectives |
| title | Drug Repositioning: Current Advances and Future Perspectives |
| title_full | Drug Repositioning: Current Advances and Future Perspectives |
| title_fullStr | Drug Repositioning: Current Advances and Future Perspectives |
| title_full_unstemmed | Drug Repositioning: Current Advances and Future Perspectives |
| title_short | Drug Repositioning: Current Advances and Future Perspectives |
| title_sort | drug repositioning current advances and future perspectives |
| topic | RM1-950 Q1-390 database Integrative strategies molecular docking polypharmacology multi-omics computational analysis Drug Repositioning data sharing Patenting thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| topic_facet | RM1-950 Q1-390 database Integrative strategies molecular docking polypharmacology multi-omics computational analysis Drug Repositioning data sharing Patenting thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| url | 32072 |
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