Dynamics of cyclic nucleotide signaling in neurons
Cyclic nucleotides control a number of neuronal properties including neuronal differentiation, pathfinding, regulation of excitability and synaptic transmission, and control of gene expression. Signaling events mediated by cAMP or cGMP are transient and take place within the complex 3-dimensional st...
Wedi'i Gadw mewn:
| Prif Awduron: | , |
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| Fformat: | Online |
| Iaith: | Saesneg |
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Frontiers Media SA
2021
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| Pynciau: | |
| Mynediad Ar-lein: | 19549 |
| Tagiau: |
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!
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| _version_ | 1869522697048817664 |
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| author | Nicholas C. Spitzer Pierre Vincent |
| author_browse | Nicholas C. Spitzer Pierre Vincent |
| author_facet | Nicholas C. Spitzer Pierre Vincent |
| author_sort | Nicholas C. Spitzer |
| collection | Directory of Open Access Books |
| description | Cyclic nucleotides control a number of neuronal properties including neuronal differentiation, pathfinding, regulation of excitability and synaptic transmission, and control of gene expression. Signaling events mediated by cAMP or cGMP are transient and take place within the complex 3-dimensional structure of the neuronal cell. Signaling events happen on the time scale of seconds to minutes and the biological significance of the temporal dimension remains poorly understood. Structural features of neurons (dendritic spines and branches, cell body, nucleus, axon…) as well as AKAPs and other scaffolding proteins that keep signaling enzymes together and form "signaling microdomains", are critical spatial determinants of signal integration. Finally, the types of enzymes involved in signal integration, which are expressed as a number of different types and splice variants, yield another dimension that determines signal integration properties. Biosensor imaging provides direct temporal and spatial measurement of intracellular signals. This novel approach, together with more conventional methods such as biochemistry, electrophysiology, and modeling, now provide a better understanding of the spatial and temporal features of cyclic nucleotide signal integration in living neurons. This topic aims at providing a better understanding of how neurons are "making sense" of cyclic nucleotide signaling in living neurons. |
| format | Online |
| id | doab-20.500.12854ir-45580 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-455802024-04-05T12:36:26Z Dynamics of cyclic nucleotide signaling in neurons Nicholas C. Spitzer Pierre Vincent RC321-571 Q1-390 rac GTP-Binding Proteins Dopamine biosensor imaging compartmentalization noradrenalin Cyclic GMP Cyclic AMP phosphodiesterases Endocannabinoids thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Cyclic nucleotides control a number of neuronal properties including neuronal differentiation, pathfinding, regulation of excitability and synaptic transmission, and control of gene expression. Signaling events mediated by cAMP or cGMP are transient and take place within the complex 3-dimensional structure of the neuronal cell. Signaling events happen on the time scale of seconds to minutes and the biological significance of the temporal dimension remains poorly understood. Structural features of neurons (dendritic spines and branches, cell body, nucleus, axon…) as well as AKAPs and other scaffolding proteins that keep signaling enzymes together and form "signaling microdomains", are critical spatial determinants of signal integration. Finally, the types of enzymes involved in signal integration, which are expressed as a number of different types and splice variants, yield another dimension that determines signal integration properties. Biosensor imaging provides direct temporal and spatial measurement of intracellular signals. This novel approach, together with more conventional methods such as biochemistry, electrophysiology, and modeling, now provide a better understanding of the spatial and temporal features of cyclic nucleotide signal integration in living neurons. This topic aims at providing a better understanding of how neurons are "making sense" of cyclic nucleotide signaling in living neurons. 2021-02-11T11:51:38Z 2021-02-11T11:51:38Z 2016-08-16 10:34:25 2015 book 19549 16648714 9782889196463 https://directory.doabooks.org/handle/20.500.12854/45580 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Dynamics_of_cyclic_nucleotide_signaling_in_neurons/685#nogo http://journal.frontiersin.org/researchtopic/2166/dynamics-of-cyclic-nucleotide-signaling-in-neurons Frontiers Media SA 10.3389/978-2-88919-646-3 10.3389/978-2-88919-646-3 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889196463 92 open access |
| spellingShingle | RC321-571 Q1-390 rac GTP-Binding Proteins Dopamine biosensor imaging compartmentalization noradrenalin Cyclic GMP Cyclic AMP phosphodiesterases Endocannabinoids thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Nicholas C. Spitzer Pierre Vincent Dynamics of cyclic nucleotide signaling in neurons |
| title | Dynamics of cyclic nucleotide signaling in neurons |
| title_full | Dynamics of cyclic nucleotide signaling in neurons |
| title_fullStr | Dynamics of cyclic nucleotide signaling in neurons |
| title_full_unstemmed | Dynamics of cyclic nucleotide signaling in neurons |
| title_short | Dynamics of cyclic nucleotide signaling in neurons |
| title_sort | dynamics of cyclic nucleotide signaling in neurons |
| topic | RC321-571 Q1-390 rac GTP-Binding Proteins Dopamine biosensor imaging compartmentalization noradrenalin Cyclic GMP Cyclic AMP phosphodiesterases Endocannabinoids thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 rac GTP-Binding Proteins Dopamine biosensor imaging compartmentalization noradrenalin Cyclic GMP Cyclic AMP phosphodiesterases Endocannabinoids thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 19549 |
| work_keys_str_mv | AT nicholascspitzer dynamicsofcyclicnucleotidesignalinginneurons AT pierrevincent dynamicsofcyclicnucleotidesignalinginneurons |