Effects of Mycotoxins on the Intestine
Mycotoxins are secondary metabolites produced by several fungal species. They can contaminate human food and animal feed, and have been a threat for thousands of years. The gastrointestinal tract is the first target when ingesting mycotoxin-contaminated food or feed. As unlikely as it sounds, the in...
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Online adgang: | 33312 |
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| author | Oswald, Isabelle P. Pinton, Philippe Alassane-Kpembi, Imourana |
| author_browse | Alassane-Kpembi, Imourana Oswald, Isabelle P. Pinton, Philippe |
| author_facet | Oswald, Isabelle P. Pinton, Philippe Alassane-Kpembi, Imourana |
| author_sort | Oswald, Isabelle P. |
| collection | Directory of Open Access Books |
| description | Mycotoxins are secondary metabolites produced by several fungal species. They can contaminate human food and animal feed, and have been a threat for thousands of years. The gastrointestinal tract is the first target when ingesting mycotoxin-contaminated food or feed. As unlikely as it sounds, the investigations concerning the effects of mycotoxins on the intestine are still in their early stages. This book gathers the most recent advances related to the characterization of the intestinal toxicity of mycotoxins. Substantial data assembled on the damage caused to a number of histological structures and functions of the intestine remove any remaining doubt about this organ being a primary target for the toxicity of mycotoxins. An interesting overview of the detrimental effects of mycotoxins on the gut-hosted microbiota—now regarded as a fully-fledged organ associated with the gut—is also given. Finally, outstanding contributions in this book address questions relating to the suitability of current regulations to protect against alterations of the intestine, and to the efficacy assessment of new detoxification strategies using the intestinal toxicity of mycotoxins as a relevant endpoint. |
| format | Online |
| id | doab-20.500.12854ir-45892 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-458922024-03-30T23:22:39Z Effects of Mycotoxins on the Intestine Oswald, Isabelle P. Pinton, Philippe Alassane-Kpembi, Imourana R5-920 RA1190-1270 toxicity intestinal epithelial cells n/a piglets toll-like receptors permeability aflatoxin M1 pig N-acetylcysteine pigs histology pre-pubertal gilts histopathological lesions Mitochondrial apoptosis explant technique Lactobacillus liver ergot alkaloids digestive tract ultrastructure hydrogen-rich water genotoxicity proliferating cell nuclear antigen mycotoxin feed intestinal morphology functional oligosaccharides Saccharomyces cerevisiae boulardii CNCM I-1079 jejunum small intestine detoxification vasoactive intestinal polypeptide PCR atlantic salmon ileum microbiota sclerotia zearalenone intestine doses mycotoxins transcriptome lipid metabolism Zearalenone caecal water mice deoxynivalenol aflatoxin B1 goblet cells inflammation intestinal bacterial flora SIEC02 cells piglet colon microbiota tight junctions tight junction suppressor of cytokine signaling ochratoxin A Claviceps T-2 toxin MiSeq 16S rDNA sequencing lactulose Clostridium sp. WJ06 swine intestinal microbiota fumonisin response contaminated feed Fusarium mycotoxins microbial diversity enteric nervous system large intestine ultrastructural changes oxidative stress thema EDItEUR::M Medicine and Nursing Mycotoxins are secondary metabolites produced by several fungal species. They can contaminate human food and animal feed, and have been a threat for thousands of years. The gastrointestinal tract is the first target when ingesting mycotoxin-contaminated food or feed. As unlikely as it sounds, the investigations concerning the effects of mycotoxins on the intestine are still in their early stages. This book gathers the most recent advances related to the characterization of the intestinal toxicity of mycotoxins. Substantial data assembled on the damage caused to a number of histological structures and functions of the intestine remove any remaining doubt about this organ being a primary target for the toxicity of mycotoxins. An interesting overview of the detrimental effects of mycotoxins on the gut-hosted microbiota—now regarded as a fully-fledged organ associated with the gut—is also given. Finally, outstanding contributions in this book address questions relating to the suitability of current regulations to protect against alterations of the intestine, and to the efficacy assessment of new detoxification strategies using the intestinal toxicity of mycotoxins as a relevant endpoint. 2021-02-11T12:09:19Z 2021-02-11T12:09:19Z 2019-05-09 17:16:14 2019 book 33312 9783038977827 9783038977834 https://directory.doabooks.org/handle/20.500.12854/45892 eng image/jpeg Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/1275 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03897-783-4 10.3390/books978-3-03897-783-4 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783038977827 9783038977834 262 open access |
| spellingShingle | R5-920 RA1190-1270 toxicity intestinal epithelial cells n/a piglets toll-like receptors permeability aflatoxin M1 pig N-acetylcysteine pigs histology pre-pubertal gilts histopathological lesions Mitochondrial apoptosis explant technique Lactobacillus liver ergot alkaloids digestive tract ultrastructure hydrogen-rich water genotoxicity proliferating cell nuclear antigen mycotoxin feed intestinal morphology functional oligosaccharides Saccharomyces cerevisiae boulardii CNCM I-1079 jejunum small intestine detoxification vasoactive intestinal polypeptide PCR atlantic salmon ileum microbiota sclerotia zearalenone intestine doses mycotoxins transcriptome lipid metabolism Zearalenone caecal water mice deoxynivalenol aflatoxin B1 goblet cells inflammation intestinal bacterial flora SIEC02 cells piglet colon microbiota tight junctions tight junction suppressor of cytokine signaling ochratoxin A Claviceps T-2 toxin MiSeq 16S rDNA sequencing lactulose Clostridium sp. WJ06 swine intestinal microbiota fumonisin response contaminated feed Fusarium mycotoxins microbial diversity enteric nervous system large intestine ultrastructural changes oxidative stress thema EDItEUR::M Medicine and Nursing Oswald, Isabelle P. Pinton, Philippe Alassane-Kpembi, Imourana Effects of Mycotoxins on the Intestine |
| title | Effects of Mycotoxins on the Intestine |
| title_full | Effects of Mycotoxins on the Intestine |
| title_fullStr | Effects of Mycotoxins on the Intestine |
| title_full_unstemmed | Effects of Mycotoxins on the Intestine |
| title_short | Effects of Mycotoxins on the Intestine |
| title_sort | effects of mycotoxins on the intestine |
| topic | R5-920 RA1190-1270 toxicity intestinal epithelial cells n/a piglets toll-like receptors permeability aflatoxin M1 pig N-acetylcysteine pigs histology pre-pubertal gilts histopathological lesions Mitochondrial apoptosis explant technique Lactobacillus liver ergot alkaloids digestive tract ultrastructure hydrogen-rich water genotoxicity proliferating cell nuclear antigen mycotoxin feed intestinal morphology functional oligosaccharides Saccharomyces cerevisiae boulardii CNCM I-1079 jejunum small intestine detoxification vasoactive intestinal polypeptide PCR atlantic salmon ileum microbiota sclerotia zearalenone intestine doses mycotoxins transcriptome lipid metabolism Zearalenone caecal water mice deoxynivalenol aflatoxin B1 goblet cells inflammation intestinal bacterial flora SIEC02 cells piglet colon microbiota tight junctions tight junction suppressor of cytokine signaling ochratoxin A Claviceps T-2 toxin MiSeq 16S rDNA sequencing lactulose Clostridium sp. WJ06 swine intestinal microbiota fumonisin response contaminated feed Fusarium mycotoxins microbial diversity enteric nervous system large intestine ultrastructural changes oxidative stress thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RA1190-1270 toxicity intestinal epithelial cells n/a piglets toll-like receptors permeability aflatoxin M1 pig N-acetylcysteine pigs histology pre-pubertal gilts histopathological lesions Mitochondrial apoptosis explant technique Lactobacillus liver ergot alkaloids digestive tract ultrastructure hydrogen-rich water genotoxicity proliferating cell nuclear antigen mycotoxin feed intestinal morphology functional oligosaccharides Saccharomyces cerevisiae boulardii CNCM I-1079 jejunum small intestine detoxification vasoactive intestinal polypeptide PCR atlantic salmon ileum microbiota sclerotia zearalenone intestine doses mycotoxins transcriptome lipid metabolism Zearalenone caecal water mice deoxynivalenol aflatoxin B1 goblet cells inflammation intestinal bacterial flora SIEC02 cells piglet colon microbiota tight junctions tight junction suppressor of cytokine signaling ochratoxin A Claviceps T-2 toxin MiSeq 16S rDNA sequencing lactulose Clostridium sp. WJ06 swine intestinal microbiota fumonisin response contaminated feed Fusarium mycotoxins microbial diversity enteric nervous system large intestine ultrastructural changes oxidative stress thema EDItEUR::M Medicine and Nursing |
| url | 33312 |
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