Emerging immune functions of non-hematopoietic stromal cells
The development and function of the immune system is dependent on interactions between haematopoietic cells and non-hematopoietic stromal cells. The non-hematopoietic stromal cells create the microenvironment in which the immune system operates, providing an architectural landscape for hematopoietic...
I tiakina i:
| Ngā kaituhi matua: | , , , |
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| Hōputu: | Online |
| Reo: | Ingarihi |
| I whakaputaina: |
Frontiers Media SA
2021
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| Ngā marau: | |
| Urunga tuihono: | 17691 |
| Ngā Tūtohu: |
Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!
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| _version_ | 1869515592537473024 |
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| author | Mark Christopher Coles Paul Kaye Burkhard Ludewig Christopher G Mueller |
| author_browse | Burkhard Ludewig Christopher G Mueller Mark Christopher Coles Paul Kaye |
| author_facet | Mark Christopher Coles Paul Kaye Burkhard Ludewig Christopher G Mueller |
| author_sort | Mark Christopher Coles |
| collection | Directory of Open Access Books |
| description | The development and function of the immune system is dependent on interactions between haematopoietic cells and non-hematopoietic stromal cells. The non-hematopoietic stromal cells create the microenvironment in which the immune system operates, providing an architectural landscape for hematopoietic cell-cell interactions and molecular cues governing haematopoietic cell positioning, growth and survival. Not surprisingly, therefore, aberrant stromal cell function has recently been shown to play a key role in the development of disease pathologies associated with immune dysfunction. For example, remodelling of lymphoid tissue stroma and the development of ectopic tertiary lymphoid tissues are characteristic of many infectious and inflammatory diseases and stromal cells have a recognised role in lymphoma and tumour development and resistance to therapy. An increased understanding of the molecular basis of stromal cell differentiation and function in these varied contexts will provide new tools to promote research on stromal cell biology and immune dysfunction, and potential new targets for therapeutic intervention in diseases with a major impact on public health. The importance of stromal cells and the molecular mechanisms of stromal cell function in the regulation of immune responses have only recently been appreciated and thus represent an exciting new area in immunology. |
| format | Online |
| id | doab-20.500.12854ir-46253 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-462532024-03-30T23:21:45Z Emerging immune functions of non-hematopoietic stromal cells Mark Christopher Coles Paul Kaye Burkhard Ludewig Christopher G Mueller R5-920 RC581-607 development endothelial cells lymphoid tissue inflammation fibroblast reticular cells thema EDItEUR::M Medicine and Nursing The development and function of the immune system is dependent on interactions between haematopoietic cells and non-hematopoietic stromal cells. The non-hematopoietic stromal cells create the microenvironment in which the immune system operates, providing an architectural landscape for hematopoietic cell-cell interactions and molecular cues governing haematopoietic cell positioning, growth and survival. Not surprisingly, therefore, aberrant stromal cell function has recently been shown to play a key role in the development of disease pathologies associated with immune dysfunction. For example, remodelling of lymphoid tissue stroma and the development of ectopic tertiary lymphoid tissues are characteristic of many infectious and inflammatory diseases and stromal cells have a recognised role in lymphoma and tumour development and resistance to therapy. An increased understanding of the molecular basis of stromal cell differentiation and function in these varied contexts will provide new tools to promote research on stromal cell biology and immune dysfunction, and potential new targets for therapeutic intervention in diseases with a major impact on public health. The importance of stromal cells and the molecular mechanisms of stromal cell function in the regulation of immune responses have only recently been appreciated and thus represent an exciting new area in immunology. 2021-02-11T12:25:57Z 2021-02-11T12:25:57Z 2015-11-19 16:29:12 2014 book 17691 16648714 9782889193622 https://directory.doabooks.org/handle/20.500.12854/46253 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Emerging_immune_functions_of_non-hematopoietic_stromal_cells/398 http://journal.frontiersin.org/researchtopic/463/emerging-immune-functions-of-non-hematopoietic-stromal-cells Frontiers Media SA 10.3389/978-2-88919-362-2 10.3389/978-2-88919-362-2 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889193622 161 open access |
| spellingShingle | R5-920 RC581-607 development endothelial cells lymphoid tissue inflammation fibroblast reticular cells thema EDItEUR::M Medicine and Nursing Mark Christopher Coles Paul Kaye Burkhard Ludewig Christopher G Mueller Emerging immune functions of non-hematopoietic stromal cells |
| title | Emerging immune functions of non-hematopoietic stromal cells |
| title_full | Emerging immune functions of non-hematopoietic stromal cells |
| title_fullStr | Emerging immune functions of non-hematopoietic stromal cells |
| title_full_unstemmed | Emerging immune functions of non-hematopoietic stromal cells |
| title_short | Emerging immune functions of non-hematopoietic stromal cells |
| title_sort | emerging immune functions of non hematopoietic stromal cells |
| topic | R5-920 RC581-607 development endothelial cells lymphoid tissue inflammation fibroblast reticular cells thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC581-607 development endothelial cells lymphoid tissue inflammation fibroblast reticular cells thema EDItEUR::M Medicine and Nursing |
| url | 17691 |
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