Engineering Synthetic Metabolons: From Metabolic Modelling to Rational Design of Biosynthetic Devices
The discipline of Synthetic Biology has recently emerged at the interface of biology and engineering. The definition of Synthetic Biology has been dynamic over time ever since, which exemplifies that the field is rapidly moving and comprises a broad range of research areas. In the frame of this Rese...
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| Автори: | , |
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| Формат: | Online |
| Мова: | Англійська |
| Опубліковано: |
Frontiers Media SA
2021
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| Предмети: | |
| Онлайн доступ: | 18308 |
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| _version_ | 1869527564857376768 |
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| author | Zoran Nikoloski Lars M. Voll |
| author_browse | Lars M. Voll Zoran Nikoloski |
| author_facet | Zoran Nikoloski Lars M. Voll |
| author_sort | Zoran Nikoloski |
| collection | Directory of Open Access Books |
| description | The discipline of Synthetic Biology has recently emerged at the interface of biology and engineering. The definition of Synthetic Biology has been dynamic over time ever since, which exemplifies that the field is rapidly moving and comprises a broad range of research areas. In the frame of this Research Topic, we focus on Synthetic Biology approaches that aim at rearranging biological parts/ entities in order to generate novel biochemical functions with inherent metabolic activity. This Research Topic encompasses Pathway Engineering in living systems as well as the in vitro assembly of biomolecules into nano- and microscale bioreactors. Both, the engineering of metabolic pathways in vivo, as well as the conceptualization of bioreactors in vitro, require rational design of assembled synthetic pathways and depend on careful selection of individual biological functions and their optimization. Mathematical modelling has proven to be a powerful tool in predicting metabolic flux in living and artificial systems, although modelling approaches have to cope with a limitation in experimentally verified, reliable input variables. This Research Topic puts special emphasis on the vital role of modelling approaches for Synthetic Biology, i.e. the predictive power of mathematical simulations for (i) the manipulation of existing pathways and (ii) the establishment of novel pathways in vivo as well as (iii) the translation of model predictions into the design of synthetic assemblies. |
| format | Online |
| id | doab-20.500.12854ir-46422 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-464222024-04-11T15:10:31Z Engineering Synthetic Metabolons: From Metabolic Modelling to Rational Design of Biosynthetic Devices Zoran Nikoloski Lars M. Voll TA1-2040 TP248.13-248.65 Metabolic Engineering reconstitution molecular dynamics simulations Membrane Transport Proteins Protein Engineering Protein scaffolds metabolite profiling Interaction domains Metabolic Modelling Starch biosynthesis thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology The discipline of Synthetic Biology has recently emerged at the interface of biology and engineering. The definition of Synthetic Biology has been dynamic over time ever since, which exemplifies that the field is rapidly moving and comprises a broad range of research areas. In the frame of this Research Topic, we focus on Synthetic Biology approaches that aim at rearranging biological parts/ entities in order to generate novel biochemical functions with inherent metabolic activity. This Research Topic encompasses Pathway Engineering in living systems as well as the in vitro assembly of biomolecules into nano- and microscale bioreactors. Both, the engineering of metabolic pathways in vivo, as well as the conceptualization of bioreactors in vitro, require rational design of assembled synthetic pathways and depend on careful selection of individual biological functions and their optimization. Mathematical modelling has proven to be a powerful tool in predicting metabolic flux in living and artificial systems, although modelling approaches have to cope with a limitation in experimentally verified, reliable input variables. This Research Topic puts special emphasis on the vital role of modelling approaches for Synthetic Biology, i.e. the predictive power of mathematical simulations for (i) the manipulation of existing pathways and (ii) the establishment of novel pathways in vivo as well as (iii) the translation of model predictions into the design of synthetic assemblies. 2021-02-11T12:35:28Z 2021-02-11T12:35:28Z 2016-01-19 14:05:46 2016 book 18308 16648714 9782889199211 https://directory.doabooks.org/handle/20.500.12854/46422 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Engineering_Synthetic_Metabolons_From_Metabolic_Modelling_to_Rational_Design_of_Biosynthetic_Device/929#nogo http://journal.frontiersin.org/researchtopic/3838/engineering-synthetic-metabolons-from-metabolic-modelling-to-rational-design-of-biosynthetic-devices Frontiers Media SA 10.3389/978-2-88919-921-1 10.3389/978-2-88919-921-1 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889199211 130 open access |
| spellingShingle | TA1-2040 TP248.13-248.65 Metabolic Engineering reconstitution molecular dynamics simulations Membrane Transport Proteins Protein Engineering Protein scaffolds metabolite profiling Interaction domains Metabolic Modelling Starch biosynthesis thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology Zoran Nikoloski Lars M. Voll Engineering Synthetic Metabolons: From Metabolic Modelling to Rational Design of Biosynthetic Devices |
| title | Engineering Synthetic Metabolons: From Metabolic Modelling to Rational Design of Biosynthetic Devices |
| title_full | Engineering Synthetic Metabolons: From Metabolic Modelling to Rational Design of Biosynthetic Devices |
| title_fullStr | Engineering Synthetic Metabolons: From Metabolic Modelling to Rational Design of Biosynthetic Devices |
| title_full_unstemmed | Engineering Synthetic Metabolons: From Metabolic Modelling to Rational Design of Biosynthetic Devices |
| title_short | Engineering Synthetic Metabolons: From Metabolic Modelling to Rational Design of Biosynthetic Devices |
| title_sort | engineering synthetic metabolons from metabolic modelling to rational design of biosynthetic devices |
| topic | TA1-2040 TP248.13-248.65 Metabolic Engineering reconstitution molecular dynamics simulations Membrane Transport Proteins Protein Engineering Protein scaffolds metabolite profiling Interaction domains Metabolic Modelling Starch biosynthesis thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology |
| topic_facet | TA1-2040 TP248.13-248.65 Metabolic Engineering reconstitution molecular dynamics simulations Membrane Transport Proteins Protein Engineering Protein scaffolds metabolite profiling Interaction domains Metabolic Modelling Starch biosynthesis thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology |
| url | 18308 |
| work_keys_str_mv | AT zorannikoloski engineeringsyntheticmetabolonsfrommetabolicmodellingtorationaldesignofbiosyntheticdevices AT larsmvoll engineeringsyntheticmetabolonsfrommetabolicmodellingtorationaldesignofbiosyntheticdevices |