Enzyme-Mediated Stereoselective Synthesis
This book is a collection of studies focused on the exploitation of enzyme stereoselectivity for the synthesis of relevant chemicals, such as innovative materials, chiral building blocks, natural products, and flavor and fragrance compounds. Different catalytic approaches are reported. The first stu...
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| Materiálatiipa: | Online |
| Giella: | eaŋgalasgiella |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Liŋkkat: | 43215 |
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| _version_ | 1869519804490055680 |
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| author | Serra, Stefano |
| author_browse | Serra, Stefano |
| author_facet | Serra, Stefano |
| author_sort | Serra, Stefano |
| collection | Directory of Open Access Books |
| description | This book is a collection of studies focused on the exploitation of enzyme stereoselectivity for the synthesis of relevant chemicals, such as innovative materials, chiral building blocks, natural products, and flavor and fragrance compounds. Different catalytic approaches are reported. The first study describes a resolution-based process for the stereoselective synthesis of the enantiomeric forms of the flavor compound linaloyl oxide, whereas other enantiomeric enriched aroma compounds were obtained through a novel microbial approach based on solid-state fermentation. Two relevant works exploit the potential of the biocatalyzed reduction reactions. The first of these contributions describes the enantioselective synthesis of ?-nitroalcohols by enzyme-mediated reduction of ?-nitroketones, whereas a second contribution reports the preparation of chiral 1,4-diaryl-1,4-diols through ADH-catalyzed bioreduction of the corresponding diketones. Concerning enantioenriched alcohol derivatives, natural hydroxy fatty acids are prepared by means of the biocatalytic hydration reaction of natural fatty acids using the probiotic bacterium Lactobacillus rhamnosus as a whole-cell biocatalyst. Further studies describe the use of modified pullulan polysaccharide for lipase immobilization and the recent advances in synthetic applications of ?-transaminases for the production of chiral amines. |
| format | Online |
| id | doab-20.500.12854ir-46650 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-466502024-04-05T12:39:08Z Enzyme-Mediated Stereoselective Synthesis Serra, Stefano QD1-999 QD146-197 Q1-390 enantioselective synthesis flavors n/a hydroxy fatty acids chiral amines diketones esters oleic acid Burkholderia cepacia lipase multi-enzymatic cascades solid-state fermentation biocatalysis agro-industrial side stream rapeseed cake enzyme-mediated resolution linolenic acid stereoselective biotransformation lipases kinetic resolution 1-phenylethanol linseed cake bioreduction Lactobacillus rhamnosus alcohol-dehydrogenase enantioselectivity hydratase reaction engineering immobilization ?-transaminases linoleic acid cyclization monoterpenes 1 lactones protein engineering asymmetric synthesis alcohol dehydrogenases linaloyl oxide chiral resolution aroma compounds 4-diols pullulan linalool reduction nitroketone thema EDItEUR::P Mathematics and Science::PN Chemistry This book is a collection of studies focused on the exploitation of enzyme stereoselectivity for the synthesis of relevant chemicals, such as innovative materials, chiral building blocks, natural products, and flavor and fragrance compounds. Different catalytic approaches are reported. The first study describes a resolution-based process for the stereoselective synthesis of the enantiomeric forms of the flavor compound linaloyl oxide, whereas other enantiomeric enriched aroma compounds were obtained through a novel microbial approach based on solid-state fermentation. Two relevant works exploit the potential of the biocatalyzed reduction reactions. The first of these contributions describes the enantioselective synthesis of ?-nitroalcohols by enzyme-mediated reduction of ?-nitroketones, whereas a second contribution reports the preparation of chiral 1,4-diaryl-1,4-diols through ADH-catalyzed bioreduction of the corresponding diketones. Concerning enantioenriched alcohol derivatives, natural hydroxy fatty acids are prepared by means of the biocatalytic hydration reaction of natural fatty acids using the probiotic bacterium Lactobacillus rhamnosus as a whole-cell biocatalyst. Further studies describe the use of modified pullulan polysaccharide for lipase immobilization and the recent advances in synthetic applications of ?-transaminases for the production of chiral amines. 2021-02-11T12:46:13Z 2021-02-11T12:46:13Z 2020-01-07 09:08:26 2019 book 43215 9783039219360 9783039219377 https://directory.doabooks.org/handle/20.500.12854/46650 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/1880 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03921-937-7 10.3390/books978-3-03921-937-7 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039219360 9783039219377 116 open access |
| spellingShingle | QD1-999 QD146-197 Q1-390 enantioselective synthesis flavors n/a hydroxy fatty acids chiral amines diketones esters oleic acid Burkholderia cepacia lipase multi-enzymatic cascades solid-state fermentation biocatalysis agro-industrial side stream rapeseed cake enzyme-mediated resolution linolenic acid stereoselective biotransformation lipases kinetic resolution 1-phenylethanol linseed cake bioreduction Lactobacillus rhamnosus alcohol-dehydrogenase enantioselectivity hydratase reaction engineering immobilization ?-transaminases linoleic acid cyclization monoterpenes 1 lactones protein engineering asymmetric synthesis alcohol dehydrogenases linaloyl oxide chiral resolution aroma compounds 4-diols pullulan linalool reduction nitroketone thema EDItEUR::P Mathematics and Science::PN Chemistry Serra, Stefano Enzyme-Mediated Stereoselective Synthesis |
| title | Enzyme-Mediated Stereoselective Synthesis |
| title_full | Enzyme-Mediated Stereoselective Synthesis |
| title_fullStr | Enzyme-Mediated Stereoselective Synthesis |
| title_full_unstemmed | Enzyme-Mediated Stereoselective Synthesis |
| title_short | Enzyme-Mediated Stereoselective Synthesis |
| title_sort | enzyme mediated stereoselective synthesis |
| topic | QD1-999 QD146-197 Q1-390 enantioselective synthesis flavors n/a hydroxy fatty acids chiral amines diketones esters oleic acid Burkholderia cepacia lipase multi-enzymatic cascades solid-state fermentation biocatalysis agro-industrial side stream rapeseed cake enzyme-mediated resolution linolenic acid stereoselective biotransformation lipases kinetic resolution 1-phenylethanol linseed cake bioreduction Lactobacillus rhamnosus alcohol-dehydrogenase enantioselectivity hydratase reaction engineering immobilization ?-transaminases linoleic acid cyclization monoterpenes 1 lactones protein engineering asymmetric synthesis alcohol dehydrogenases linaloyl oxide chiral resolution aroma compounds 4-diols pullulan linalool reduction nitroketone thema EDItEUR::P Mathematics and Science::PN Chemistry |
| topic_facet | QD1-999 QD146-197 Q1-390 enantioselective synthesis flavors n/a hydroxy fatty acids chiral amines diketones esters oleic acid Burkholderia cepacia lipase multi-enzymatic cascades solid-state fermentation biocatalysis agro-industrial side stream rapeseed cake enzyme-mediated resolution linolenic acid stereoselective biotransformation lipases kinetic resolution 1-phenylethanol linseed cake bioreduction Lactobacillus rhamnosus alcohol-dehydrogenase enantioselectivity hydratase reaction engineering immobilization ?-transaminases linoleic acid cyclization monoterpenes 1 lactones protein engineering asymmetric synthesis alcohol dehydrogenases linaloyl oxide chiral resolution aroma compounds 4-diols pullulan linalool reduction nitroketone thema EDItEUR::P Mathematics and Science::PN Chemistry |
| url | 43215 |
| work_keys_str_mv | AT serrastefano enzymemediatedstereoselectivesynthesis |