Epigenetic pathways in PTSD: How traumatic experiences leave their signature on the genome
This research topic focuses on epigenetic components of PTSD. Epigenetic mechanisms are a class of molecular mechanisms by which environmental influences, including stress, can interact with the genome to have long-term consequences for brain plasticity and behavior. Articles herein include empirica...
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| Formato: | Online |
| Idioma: | inglês |
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Frontiers Media SA
2021
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| Acesso em linha: | 18604 |
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| _version_ | 1869522879681396736 |
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| author | Tania L. Roth Karestan C. Koenen David M. Diamond |
| author_browse | David M. Diamond Karestan C. Koenen Tania L. Roth |
| author_facet | Tania L. Roth Karestan C. Koenen David M. Diamond |
| author_sort | Tania L. Roth |
| collection | Directory of Open Access Books |
| description | This research topic focuses on epigenetic components of PTSD. Epigenetic mechanisms are a class of molecular mechanisms by which environmental influences, including stress, can interact with the genome to have long-term consequences for brain plasticity and behavior. Articles herein include empirical reports and reviews that link stress and trauma with epigenetic alterations in humans and animal models of early- or later-life stress. Themes present throughout the collection include: DNA methylation is a useful biomarker of stress and treatment outcome in humans; epigenetic programming of stress-sensitive physiological systems early in development confers an enhanced risk on disease development upon re-exposure to trauma or stress; and, long-lived fear memories are associated with epigenetic alterations in fear memory and extinction brain circuitry. |
| format | Online |
| id | doab-20.500.12854ir-46667 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-466672024-03-30T23:23:05Z Epigenetic pathways in PTSD: How traumatic experiences leave their signature on the genome Tania L. Roth Karestan C. Koenen David M. Diamond R5-920 RC435-571 PTSD stress Fear DNA Methylation Histones miRNA thema EDItEUR::M Medicine and Nursing This research topic focuses on epigenetic components of PTSD. Epigenetic mechanisms are a class of molecular mechanisms by which environmental influences, including stress, can interact with the genome to have long-term consequences for brain plasticity and behavior. Articles herein include empirical reports and reviews that link stress and trauma with epigenetic alterations in humans and animal models of early- or later-life stress. Themes present throughout the collection include: DNA methylation is a useful biomarker of stress and treatment outcome in humans; epigenetic programming of stress-sensitive physiological systems early in development confers an enhanced risk on disease development upon re-exposure to trauma or stress; and, long-lived fear memories are associated with epigenetic alterations in fear memory and extinction brain circuitry. 2021-02-11T12:47:11Z 2021-02-11T12:47:11Z 2016-02-05 17:24:33 2015 book 18604 16648714 9782889194582 https://directory.doabooks.org/handle/20.500.12854/46667 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Epigenetic_pathways_in_PTSD_how_traumatic_experiences_leave_their_signature_on_the_genome/490 http://journal.frontiersin.org/researchtopic/966/epigenetic-pathways-in-ptsd-how-traumatic-experiences-leave-their-signature-on-the-genome Frontiers Media SA 10.3389/978-2-88919-458-2 10.3389/978-2-88919-458-2 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889194582 158 open access |
| spellingShingle | R5-920 RC435-571 PTSD stress Fear DNA Methylation Histones miRNA thema EDItEUR::M Medicine and Nursing Tania L. Roth Karestan C. Koenen David M. Diamond Epigenetic pathways in PTSD: How traumatic experiences leave their signature on the genome |
| title | Epigenetic pathways in PTSD: How traumatic experiences leave their signature on the genome |
| title_full | Epigenetic pathways in PTSD: How traumatic experiences leave their signature on the genome |
| title_fullStr | Epigenetic pathways in PTSD: How traumatic experiences leave their signature on the genome |
| title_full_unstemmed | Epigenetic pathways in PTSD: How traumatic experiences leave their signature on the genome |
| title_short | Epigenetic pathways in PTSD: How traumatic experiences leave their signature on the genome |
| title_sort | epigenetic pathways in ptsd how traumatic experiences leave their signature on the genome |
| topic | R5-920 RC435-571 PTSD stress Fear DNA Methylation Histones miRNA thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC435-571 PTSD stress Fear DNA Methylation Histones miRNA thema EDItEUR::M Medicine and Nursing |
| url | 18604 |
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