The Epithelial-to-Mesenchymal Transition (EMT) in Cancer
The epithelial-to-mesenchymal transition (EMT) is a highly dynamic process with multiple transitional states, by which epithelial cells can convert into a mesenchymal phenotype. This process involves loss of cellular adhesion and cellular polarity, and an improvement in migratory and invasive proper...
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| Формат: | Online |
| Мова: | Англійська |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Предмети: | |
| Онлайн доступ: | 26629 |
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| _version_ | 1869528454008930304 |
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| author | Joëlle Roche (Ed.) |
| author_browse | Joëlle Roche (Ed.) |
| author_facet | Joëlle Roche (Ed.) |
| author_sort | Joëlle Roche (Ed.) |
| collection | Directory of Open Access Books |
| description | The epithelial-to-mesenchymal transition (EMT) is a highly dynamic process with multiple transitional states, by which epithelial cells can convert into a mesenchymal phenotype. This process involves loss of cellular adhesion and cellular polarity, and an improvement in migratory and invasive properties. It occurs during normal embryonic development, tissue regeneration, organ fibrosis, and wound healing. It is also involved in tumor progression with metastatic expansion, and plays a major role in resistance to cancer treatment. In cancers, EMT inducers are hypoxia, cytokines and growth factors secreted by the tumor microenvironment, stroma crosstalk, metabolic changes, innate and adaptive immune responses, and treatment with antitumor drugs. Switch in gene expression from epithelial to mesenchymal phenotype is triggered by complex regulatory networks involving transcriptional control, non-coding RNAs, chromatin remodeling and epigenetic modifications, alternative splicing, post-translational regulation, protein stability and subcellular localization. Reversion of EMT, the mesenchymal-to-epithelial transition (MET), affects circulating cancer cells when they reach a desirable metastatic niche to develop secondary tumors. More knowledge and control of EMT to MET is necessary and will be beneficial for patients for cancer treatment. This current Special Issue entitled “Epithelial to Mesenchymal Transition in Cancer” will address these questions. |
| format | Online |
| id | doab-20.500.12854ir-46689 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-466892024-04-05T12:33:27Z The Epithelial-to-Mesenchymal Transition (EMT) in Cancer Joëlle Roche (Ed.) QH301-705.5 PLK1 CK2 epigenetics cancer therapy chemoresistance TGF-beta metastasis non-coding RNAs exosomes cancer epithelial-to-pericyte transition (EPT) Epithelial-to-mesenchymal transition (EMT) thema EDItEUR::P Mathematics and Science::PS Biology, life sciences The epithelial-to-mesenchymal transition (EMT) is a highly dynamic process with multiple transitional states, by which epithelial cells can convert into a mesenchymal phenotype. This process involves loss of cellular adhesion and cellular polarity, and an improvement in migratory and invasive properties. It occurs during normal embryonic development, tissue regeneration, organ fibrosis, and wound healing. It is also involved in tumor progression with metastatic expansion, and plays a major role in resistance to cancer treatment. In cancers, EMT inducers are hypoxia, cytokines and growth factors secreted by the tumor microenvironment, stroma crosstalk, metabolic changes, innate and adaptive immune responses, and treatment with antitumor drugs. Switch in gene expression from epithelial to mesenchymal phenotype is triggered by complex regulatory networks involving transcriptional control, non-coding RNAs, chromatin remodeling and epigenetic modifications, alternative splicing, post-translational regulation, protein stability and subcellular localization. Reversion of EMT, the mesenchymal-to-epithelial transition (MET), affects circulating cancer cells when they reach a desirable metastatic niche to develop secondary tumors. More knowledge and control of EMT to MET is necessary and will be beneficial for patients for cancer treatment. This current Special Issue entitled “Epithelial to Mesenchymal Transition in Cancer” will address these questions. 2021-02-11T12:48:24Z 2021-02-11T12:48:24Z 2018-04-27 16:09:54 2018 book 26629 9783038427940 9783038427933 https://directory.doabooks.org/handle/20.500.12854/46689 eng image/png Attribution-NonCommercial-NoDerivatives 4.0 International http://www.mdpi.com/books/pdfview/book/573 http://www.mdpi.com/books/pdfview/book/573 MDPI - Multidisciplinary Digital Publishing Institute 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783038427940 9783038427933 VI, 254 open access |
| spellingShingle | QH301-705.5 PLK1 CK2 epigenetics cancer therapy chemoresistance TGF-beta metastasis non-coding RNAs exosomes cancer epithelial-to-pericyte transition (EPT) Epithelial-to-mesenchymal transition (EMT) thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Joëlle Roche (Ed.) The Epithelial-to-Mesenchymal Transition (EMT) in Cancer |
| title | The Epithelial-to-Mesenchymal Transition (EMT) in Cancer |
| title_full | The Epithelial-to-Mesenchymal Transition (EMT) in Cancer |
| title_fullStr | The Epithelial-to-Mesenchymal Transition (EMT) in Cancer |
| title_full_unstemmed | The Epithelial-to-Mesenchymal Transition (EMT) in Cancer |
| title_short | The Epithelial-to-Mesenchymal Transition (EMT) in Cancer |
| title_sort | epithelial to mesenchymal transition emt in cancer |
| topic | QH301-705.5 PLK1 CK2 epigenetics cancer therapy chemoresistance TGF-beta metastasis non-coding RNAs exosomes cancer epithelial-to-pericyte transition (EPT) Epithelial-to-mesenchymal transition (EMT) thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | QH301-705.5 PLK1 CK2 epigenetics cancer therapy chemoresistance TGF-beta metastasis non-coding RNAs exosomes cancer epithelial-to-pericyte transition (EPT) Epithelial-to-mesenchymal transition (EMT) thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | 26629 |
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