Essential Pathways and Circuits of Autism Pathogenesis
The Centers for Disease Control and Prevention estimate that 1 in 68 children in the United states is afflicted with autism spectrum disorders (ASD), yet at this time, there is no cure for the disease. Autism is characterized by delays in the development of many basic skills, most notably the abilit...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , |
|---|---|
| Μορφή: | Online |
| Γλώσσα: | Αγγλικά |
| Έκδοση: |
Frontiers Media SA
2021
|
| Θέματα: | |
| Διαθέσιμο Online: | 18292 |
| Ετικέτες: |
Δεν υπάρχουν, Καταχωρήστε ετικέτα πρώτοι!
|
| _version_ | 1869515975161806848 |
|---|---|
| author | Gul Dolen Mustafa Sahin |
| author_browse | Gul Dolen Mustafa Sahin |
| author_facet | Gul Dolen Mustafa Sahin |
| author_sort | Gul Dolen |
| collection | Directory of Open Access Books |
| description | The Centers for Disease Control and Prevention estimate that 1 in 68 children in the United states is afflicted with autism spectrum disorders (ASD), yet at this time, there is no cure for the disease. Autism is characterized by delays in the development of many basic skills, most notably the ability to socialize and adapt to novelty. The condition is typically identified in children around 3 years of age, however the high heritability of autism suggests that the disease process begins at conception. The identification of over 500 ASD risk genes, has enabled the molecular genetic dissection of the pathogenesis of the disease in model organisms such as mice. Despite the genetic heterogeneity of ASD etiology, converging evidence suggests that these disparate genetic lesions may result in the disruption of a limited number of key biochemical pathways or circuits. Classification of patients into groups by pathogenic rather than etiological categories, will likely aid future therapeutic development and clinical trials. In this set of papers, we explore the existing evidence supporting this view. Specifically, we focus on biochemical cascades such as mTOR and ERK signaling, the mRNA network bound by FMRP and UBE3A, dorsal and ventral striatal circuits, cerebellar circuits, hypothalamic projections, as well as prefrontal and anterior cingulate cortical circuits. Special attention will be given to studies that demonstrate the necessity and/or sufficiency of genetic disruptions (e.g. by molecular deletion and/or replacement) in these pathways and circuits for producing characteristic behavioral features of autism. Necessarily these papers will be heavily weighted towards basic mechanisms elucidated in animal models, but may also include investigations in patients. |
| format | Online |
| id | doab-20.500.12854ir-46856 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-468562024-04-05T12:35:34Z Essential Pathways and Circuits of Autism Pathogenesis Gul Dolen Mustafa Sahin RC321-571 QH426-470 Q1-390 Cerebellum Striatum Oxytocin mTOR Hypothalamus Neurodevelopmental disorders Cell signaling thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences The Centers for Disease Control and Prevention estimate that 1 in 68 children in the United states is afflicted with autism spectrum disorders (ASD), yet at this time, there is no cure for the disease. Autism is characterized by delays in the development of many basic skills, most notably the ability to socialize and adapt to novelty. The condition is typically identified in children around 3 years of age, however the high heritability of autism suggests that the disease process begins at conception. The identification of over 500 ASD risk genes, has enabled the molecular genetic dissection of the pathogenesis of the disease in model organisms such as mice. Despite the genetic heterogeneity of ASD etiology, converging evidence suggests that these disparate genetic lesions may result in the disruption of a limited number of key biochemical pathways or circuits. Classification of patients into groups by pathogenic rather than etiological categories, will likely aid future therapeutic development and clinical trials. In this set of papers, we explore the existing evidence supporting this view. Specifically, we focus on biochemical cascades such as mTOR and ERK signaling, the mRNA network bound by FMRP and UBE3A, dorsal and ventral striatal circuits, cerebellar circuits, hypothalamic projections, as well as prefrontal and anterior cingulate cortical circuits. Special attention will be given to studies that demonstrate the necessity and/or sufficiency of genetic disruptions (e.g. by molecular deletion and/or replacement) in these pathways and circuits for producing characteristic behavioral features of autism. Necessarily these papers will be heavily weighted towards basic mechanisms elucidated in animal models, but may also include investigations in patients. 2021-02-11T12:57:32Z 2021-02-11T12:57:32Z 2016-01-19 14:05:46 2016 book 18292 16648714 9782889199051 https://directory.doabooks.org/handle/20.500.12854/46856 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Essential_Pathways_and_Circuits_of_Autism_Pathogenesis/963#nogo http://journal.frontiersin.org/researchtopic/3508/essential-pathways-and-circuits-of-autism-pathogenesis Frontiers Media SA 10.3389/978-2-88919-905-1 10.3389/978-2-88919-905-1 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889199051 181 open access |
| spellingShingle | RC321-571 QH426-470 Q1-390 Cerebellum Striatum Oxytocin mTOR Hypothalamus Neurodevelopmental disorders Cell signaling thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Gul Dolen Mustafa Sahin Essential Pathways and Circuits of Autism Pathogenesis |
| title | Essential Pathways and Circuits of Autism Pathogenesis |
| title_full | Essential Pathways and Circuits of Autism Pathogenesis |
| title_fullStr | Essential Pathways and Circuits of Autism Pathogenesis |
| title_full_unstemmed | Essential Pathways and Circuits of Autism Pathogenesis |
| title_short | Essential Pathways and Circuits of Autism Pathogenesis |
| title_sort | essential pathways and circuits of autism pathogenesis |
| topic | RC321-571 QH426-470 Q1-390 Cerebellum Striatum Oxytocin mTOR Hypothalamus Neurodevelopmental disorders Cell signaling thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 QH426-470 Q1-390 Cerebellum Striatum Oxytocin mTOR Hypothalamus Neurodevelopmental disorders Cell signaling thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 18292 |
| work_keys_str_mv | AT guldolen essentialpathwaysandcircuitsofautismpathogenesis AT mustafasahin essentialpathwaysandcircuitsofautismpathogenesis |