The Evolution and Development of the Antibody Repertoire
Although at first glance mechanisms used to create the variable domains of immunoglobulin appear to be designed to generate diversity at random, closer inspection reveals striking evolutionary constraints on the sequence and structure of these antigen receptors, suggesting that natural selection is...
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| Materialtyp: | Online |
| Språk: | engelska |
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Frontiers Media SA
2021
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| Länkar: | 18158 |
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| _version_ | 1869519081174990848 |
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| author | Harry W Schroeder Jr |
| author_browse | Harry W Schroeder Jr |
| author_facet | Harry W Schroeder Jr |
| author_sort | Harry W Schroeder Jr |
| collection | Directory of Open Access Books |
| description | Although at first glance mechanisms used to create the variable domains of immunoglobulin appear to be designed to generate diversity at random, closer inspection reveals striking evolutionary constraints on the sequence and structure of these antigen receptors, suggesting that natural selection is operating to create a repertoire that anticipates or is biased towards recognition of specific antigenic properties. This Research Topics issue will be devoted to an examination of the evolution of antigen receptor sequence at the germline level, an evaluation of the repertoire in B cells from fish, pigs and human, an introduction into bioinformatics approaches to the evaluation and analysis of the repertoire as ascertained by high throughput sequencing, and a discussion of how study of the normal repertoire informs the construction or selection of in vitro antibodies for applied purposes. |
| format | Online |
| id | doab-20.500.12854ir-47132 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-471322024-03-30T23:22:26Z The Evolution and Development of the Antibody Repertoire Harry W Schroeder Jr R5-920 RC581-607 Antibody repertoire immunoglobulin B cells sequence analysis software comparative immunology natural antibodies thema EDItEUR::M Medicine and Nursing Although at first glance mechanisms used to create the variable domains of immunoglobulin appear to be designed to generate diversity at random, closer inspection reveals striking evolutionary constraints on the sequence and structure of these antigen receptors, suggesting that natural selection is operating to create a repertoire that anticipates or is biased towards recognition of specific antigenic properties. This Research Topics issue will be devoted to an examination of the evolution of antigen receptor sequence at the germline level, an evaluation of the repertoire in B cells from fish, pigs and human, an introduction into bioinformatics approaches to the evaluation and analysis of the repertoire as ascertained by high throughput sequencing, and a discussion of how study of the normal repertoire informs the construction or selection of in vitro antibodies for applied purposes. 2021-02-11T13:12:19Z 2021-02-11T13:12:19Z 2016-01-19 14:05:46 2015 book 18158 16648714 9782889195497 https://directory.doabooks.org/handle/20.500.12854/47132 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/The_Evolution_and_Development_of_the_Antibody_Repertoire/548#nogo http://journal.frontiersin.org/researchtopic/369/the-evolution-and-development-of-the-antibody-repertoire Frontiers Media SA 10.3389/978-2-88919-549-7 10.3389/978-2-88919-549-7 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889195497 122 open access |
| spellingShingle | R5-920 RC581-607 Antibody repertoire immunoglobulin B cells sequence analysis software comparative immunology natural antibodies thema EDItEUR::M Medicine and Nursing Harry W Schroeder Jr The Evolution and Development of the Antibody Repertoire |
| title | The Evolution and Development of the Antibody Repertoire |
| title_full | The Evolution and Development of the Antibody Repertoire |
| title_fullStr | The Evolution and Development of the Antibody Repertoire |
| title_full_unstemmed | The Evolution and Development of the Antibody Repertoire |
| title_short | The Evolution and Development of the Antibody Repertoire |
| title_sort | evolution and development of the antibody repertoire |
| topic | R5-920 RC581-607 Antibody repertoire immunoglobulin B cells sequence analysis software comparative immunology natural antibodies thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC581-607 Antibody repertoire immunoglobulin B cells sequence analysis software comparative immunology natural antibodies thema EDItEUR::M Medicine and Nursing |
| url | 18158 |
| work_keys_str_mv | AT harrywschroederjr theevolutionanddevelopmentoftheantibodyrepertoire AT harrywschroederjr evolutionanddevelopmentoftheantibodyrepertoire |