Experimental models of early exposure to alcohol: a way to unravel the neurobiology of mental retardation
Excessive alcohol drinking represents a major social and public health problem for several countries. Alcohol abuse during pregnancy leads to a complex syndrome referred to as fetal alcohol spectrum disorders (FASD), chiefly characterized by mental retardation. The effects of early exposure to ethan...
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| Format: | Online |
| Idioma: | anglès |
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Frontiers Media SA
2021
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| Accés en línia: | 18723 |
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| _version_ | 1869515453910482944 |
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| author | Alberto Granato Andrea De Giorgio |
| author_browse | Alberto Granato Andrea De Giorgio |
| author_facet | Alberto Granato Andrea De Giorgio |
| author_sort | Alberto Granato |
| collection | Directory of Open Access Books |
| description | Excessive alcohol drinking represents a major social and public health problem for several countries. Alcohol abuse during pregnancy leads to a complex syndrome referred to as fetal alcohol spectrum disorders (FASD), chiefly characterized by mental retardation. The effects of early exposure to ethanol can be reproduced in laboratory animals and this helped to answer several key questions concerning the human pathology. The interest of experimental models of FASD is twofold. First, they increase our knowledge about the dose and modality of alcohol consumption able to induce damaging effects on the developing brain. Second, experimental models of FASD can provide useful hints to elucidate the basic mechanisms leading to the intellectual disability. In fact, experimental exposure to alcohol can be carried out during discrete, often very restricted, time windows. As a consequence, FASD models, though depending on the multifaceted interference of alcohol with several molecular pathways, can provide valuable information about which specific developmental periods and brain areas are critically involved in the genesis of mental retardation. Putting together data obtained through several experimental paradigms of alcohol exposure and those deriving from other genetic and non-genetic models, one can figure out to what extent different types of mental retardation share common pathogenetic mechanisms. The present Research Topic is aimed at establishing the state of the art of the current research on experimental FASD, focusing on differences and homologies with other types of intellectual disability. The ultimate goal is to find out a common roadmap in view of future therapeutical approaches. |
| format | Online |
| id | doab-20.500.12854ir-47206 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-472062024-03-30T23:21:44Z Experimental models of early exposure to alcohol: a way to unravel the neurobiology of mental retardation Alberto Granato Andrea De Giorgio R5-920 RC435-571 RJ1-570 glial cells development Amygdala Fetal Alcohol Spectrum Disorders Cerebral Cortex Intellectual Disability epigenetics Apoptosis thema EDItEUR::M Medicine and Nursing Excessive alcohol drinking represents a major social and public health problem for several countries. Alcohol abuse during pregnancy leads to a complex syndrome referred to as fetal alcohol spectrum disorders (FASD), chiefly characterized by mental retardation. The effects of early exposure to ethanol can be reproduced in laboratory animals and this helped to answer several key questions concerning the human pathology. The interest of experimental models of FASD is twofold. First, they increase our knowledge about the dose and modality of alcohol consumption able to induce damaging effects on the developing brain. Second, experimental models of FASD can provide useful hints to elucidate the basic mechanisms leading to the intellectual disability. In fact, experimental exposure to alcohol can be carried out during discrete, often very restricted, time windows. As a consequence, FASD models, though depending on the multifaceted interference of alcohol with several molecular pathways, can provide valuable information about which specific developmental periods and brain areas are critically involved in the genesis of mental retardation. Putting together data obtained through several experimental paradigms of alcohol exposure and those deriving from other genetic and non-genetic models, one can figure out to what extent different types of mental retardation share common pathogenetic mechanisms. The present Research Topic is aimed at establishing the state of the art of the current research on experimental FASD, focusing on differences and homologies with other types of intellectual disability. The ultimate goal is to find out a common roadmap in view of future therapeutical approaches. 2021-02-11T13:17:09Z 2021-02-11T13:17:09Z 2016-03-10 08:14:33 2015 book 18723 16648714 9782889194728 https://directory.doabooks.org/handle/20.500.12854/47206 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Experimental_models_of_early_exposure_to_alcohol_a_way_to_unravel_the_neurobiology_of_mental_retard/423#nogo http://journal.frontiersin.org/researchtopic/2207/experimental-models-of-early-exposure-to-alcohol-a-way-to-unravel-the-neurobiology-of-mental-retarda Frontiers Media SA 10.3389/978-2-88919-472-8 10.3389/978-2-88919-472-8 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889194728 104 open access |
| spellingShingle | R5-920 RC435-571 RJ1-570 glial cells development Amygdala Fetal Alcohol Spectrum Disorders Cerebral Cortex Intellectual Disability epigenetics Apoptosis thema EDItEUR::M Medicine and Nursing Alberto Granato Andrea De Giorgio Experimental models of early exposure to alcohol: a way to unravel the neurobiology of mental retardation |
| title | Experimental models of early exposure to alcohol: a way to unravel the neurobiology of mental retardation |
| title_full | Experimental models of early exposure to alcohol: a way to unravel the neurobiology of mental retardation |
| title_fullStr | Experimental models of early exposure to alcohol: a way to unravel the neurobiology of mental retardation |
| title_full_unstemmed | Experimental models of early exposure to alcohol: a way to unravel the neurobiology of mental retardation |
| title_short | Experimental models of early exposure to alcohol: a way to unravel the neurobiology of mental retardation |
| title_sort | experimental models of early exposure to alcohol a way to unravel the neurobiology of mental retardation |
| topic | R5-920 RC435-571 RJ1-570 glial cells development Amygdala Fetal Alcohol Spectrum Disorders Cerebral Cortex Intellectual Disability epigenetics Apoptosis thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC435-571 RJ1-570 glial cells development Amygdala Fetal Alcohol Spectrum Disorders Cerebral Cortex Intellectual Disability epigenetics Apoptosis thema EDItEUR::M Medicine and Nursing |
| url | 18723 |
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