Function of Renal Sympathetic Nerves
Sympathetic overactivity is associated with the development of hypertension. Renal denervation (RDN) prevents or delays hypertension in a variety of animal models, which laid the groundwork for the introduction of RDN as a clinical therapy in humans. In 2007, a novel, minimally invasive RDN ablation...
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| Format: | Online |
| Idioma: | anglès |
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Frontiers Media SA
2021
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| Accés en línia: | 25604 |
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| _version_ | 1869514568643903488 |
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| author | Yutang Wang Kate M. Denton Kyungjoon Lim |
| author_browse | Kate M. Denton Kyungjoon Lim Yutang Wang |
| author_facet | Yutang Wang Kate M. Denton Kyungjoon Lim |
| author_sort | Yutang Wang |
| collection | Directory of Open Access Books |
| description | Sympathetic overactivity is associated with the development of hypertension. Renal denervation (RDN) prevents or delays hypertension in a variety of animal models, which laid the groundwork for the introduction of RDN as a clinical therapy in humans. In 2007, a novel, minimally invasive RDN ablation catheter was first trialled in hypertensive patients, with a 93% success rate of lowering blood pressure for at least three years post-RDN. However, a large scale, sham-controlled clinical trial (Symplicity HTN -3) failed to show reductions in BP greater than sham. The aim of this research topic was to evaluate the efficacy and safety of RDN, to explore the contribution of both afferent and efferent renal nerve activity to hypertension and non-hypertension disorders, and to stimulate future research to better understand the function of the renal nerves and the effects of RDN by highlighting gaps in knowledge. |
| format | Online |
| id | doab-20.500.12854ir-48184 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-481842024-03-31T22:45:04Z Function of Renal Sympathetic Nerves Yutang Wang Kate M. Denton Kyungjoon Lim QP1-981 Q1-390 atherosclerosis heart failure renal denervation renal sympathetic nerves kidney disease hypertension thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology Sympathetic overactivity is associated with the development of hypertension. Renal denervation (RDN) prevents or delays hypertension in a variety of animal models, which laid the groundwork for the introduction of RDN as a clinical therapy in humans. In 2007, a novel, minimally invasive RDN ablation catheter was first trialled in hypertensive patients, with a 93% success rate of lowering blood pressure for at least three years post-RDN. However, a large scale, sham-controlled clinical trial (Symplicity HTN -3) failed to show reductions in BP greater than sham. The aim of this research topic was to evaluate the efficacy and safety of RDN, to explore the contribution of both afferent and efferent renal nerve activity to hypertension and non-hypertension disorders, and to stimulate future research to better understand the function of the renal nerves and the effects of RDN by highlighting gaps in knowledge. 2021-02-11T14:10:40Z 2021-02-11T14:10:40Z 2018-02-27 16:16:44 2017 book 25604 16648714 9782889452958 https://directory.doabooks.org/handle/20.500.12854/48184 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/books/Function_of_Renal_Sympathetic_Nerves/1361 https://www.frontiersin.org/research-topics/2928/function-of-renal-sympathetic-nerves Frontiers Media SA 10.3389/978-2-88945-295-8 10.3389/978-2-88945-295-8 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889452958 96 open access |
| spellingShingle | QP1-981 Q1-390 atherosclerosis heart failure renal denervation renal sympathetic nerves kidney disease hypertension thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology Yutang Wang Kate M. Denton Kyungjoon Lim Function of Renal Sympathetic Nerves |
| title | Function of Renal Sympathetic Nerves |
| title_full | Function of Renal Sympathetic Nerves |
| title_fullStr | Function of Renal Sympathetic Nerves |
| title_full_unstemmed | Function of Renal Sympathetic Nerves |
| title_short | Function of Renal Sympathetic Nerves |
| title_sort | function of renal sympathetic nerves |
| topic | QP1-981 Q1-390 atherosclerosis heart failure renal denervation renal sympathetic nerves kidney disease hypertension thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| topic_facet | QP1-981 Q1-390 atherosclerosis heart failure renal denervation renal sympathetic nerves kidney disease hypertension thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| url | 25604 |
| work_keys_str_mv | AT yutangwang functionofrenalsympatheticnerves AT katemdenton functionofrenalsympatheticnerves AT kyungjoonlim functionofrenalsympatheticnerves |