Fungal Pathogenesis in Humans: The Growing Threat
Cancer survival rates and successful organ transplantation in patients continues to increase due to improvements in early diagnosis and treatments. Since immuno-suppressive therapies are frequently used, the mortality rate due to secondary infections has become an ever-increasing problem. Opportunis...
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| Formato: | Online |
| Lenguaje: | inglés |
| Publicado: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Materias: | |
| Acceso en línea: | 33666 |
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| _version_ | 1869530919968178176 |
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| author | Leal, Fernando |
| author_browse | Leal, Fernando |
| author_facet | Leal, Fernando |
| author_sort | Leal, Fernando |
| collection | Directory of Open Access Books |
| description | Cancer survival rates and successful organ transplantation in patients continues to increase due to improvements in early diagnosis and treatments. Since immuno-suppressive therapies are frequently used, the mortality rate due to secondary infections has become an ever-increasing problem. Opportunistic fungal infections are probably the deadliest threat to these patients due to their difficult early diagnosis, the limited effect of antifungal drugs and the appearance of resistances. In recent years, a considerable effort has been devoted to investigating the role of many virulence traits in the pathogenic outcome of fungal infections. New virulence factors (hypoxia adaptation, CO2 sensing, pH regulation, micronutrient acquisition, secondary metabolites, immunity regulators, etc.) have been reported and their molecular mechanisms of action are being thoroughly investigated. The recent application of gene-editing technologies such as CRISPr-Cas9, has opened a whole new window to the discovery of new fungal virulence factors. Accurate fungal genotyping, Next Generation Sequencing and RNAseq approaches will undoubtedly provide new clues to interpret the plethora of molecular interactions controlling these complex systems. Unraveling their intimate regulatory details will provide insights for a more target-focused search or a rational design of more specific antifungal agents. This Special Issue is show significant discoveries, proofs of concept of new theories or relevant observations in fungal pathogenesis and its regulation. |
| format | Online |
| id | doab-20.500.12854ir-48213 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-482132024-04-05T12:35:15Z Fungal Pathogenesis in Humans: The Growing Threat Leal, Fernando QH426-470 QH301-705.5 Q1-390 CO2 sensing Micronutrient acquisition Biofilm formation Secondary metabolites and toxins Criptococcus Fungal virulence Immune evasion pH regulation Pneumocysits Aspergillus Regulation of antifungals resistance Candida Fusarium Trehalose biosynthesis Fungal genotyping Scedosporium thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) Cancer survival rates and successful organ transplantation in patients continues to increase due to improvements in early diagnosis and treatments. Since immuno-suppressive therapies are frequently used, the mortality rate due to secondary infections has become an ever-increasing problem. Opportunistic fungal infections are probably the deadliest threat to these patients due to their difficult early diagnosis, the limited effect of antifungal drugs and the appearance of resistances. In recent years, a considerable effort has been devoted to investigating the role of many virulence traits in the pathogenic outcome of fungal infections. New virulence factors (hypoxia adaptation, CO2 sensing, pH regulation, micronutrient acquisition, secondary metabolites, immunity regulators, etc.) have been reported and their molecular mechanisms of action are being thoroughly investigated. The recent application of gene-editing technologies such as CRISPr-Cas9, has opened a whole new window to the discovery of new fungal virulence factors. Accurate fungal genotyping, Next Generation Sequencing and RNAseq approaches will undoubtedly provide new clues to interpret the plethora of molecular interactions controlling these complex systems. Unraveling their intimate regulatory details will provide insights for a more target-focused search or a rational design of more specific antifungal agents. This Special Issue is show significant discoveries, proofs of concept of new theories or relevant observations in fungal pathogenesis and its regulation. 2021-02-11T14:13:45Z 2021-02-11T14:13:45Z 2019-06-26 08:44:06 2019 book 33666 9783038979012 9783038979005 https://directory.doabooks.org/handle/20.500.12854/48213 eng image/jpeg Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/1326 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03897-901-2 10.3390/books978-3-03897-901-2 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783038979012 9783038979005 232 open access |
| spellingShingle | QH426-470 QH301-705.5 Q1-390 CO2 sensing Micronutrient acquisition Biofilm formation Secondary metabolites and toxins Criptococcus Fungal virulence Immune evasion pH regulation Pneumocysits Aspergillus Regulation of antifungals resistance Candida Fusarium Trehalose biosynthesis Fungal genotyping Scedosporium thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) Leal, Fernando Fungal Pathogenesis in Humans: The Growing Threat |
| title | Fungal Pathogenesis in Humans: The Growing Threat |
| title_full | Fungal Pathogenesis in Humans: The Growing Threat |
| title_fullStr | Fungal Pathogenesis in Humans: The Growing Threat |
| title_full_unstemmed | Fungal Pathogenesis in Humans: The Growing Threat |
| title_short | Fungal Pathogenesis in Humans: The Growing Threat |
| title_sort | fungal pathogenesis in humans the growing threat |
| topic | QH426-470 QH301-705.5 Q1-390 CO2 sensing Micronutrient acquisition Biofilm formation Secondary metabolites and toxins Criptococcus Fungal virulence Immune evasion pH regulation Pneumocysits Aspergillus Regulation of antifungals resistance Candida Fusarium Trehalose biosynthesis Fungal genotyping Scedosporium thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) |
| topic_facet | QH426-470 QH301-705.5 Q1-390 CO2 sensing Micronutrient acquisition Biofilm formation Secondary metabolites and toxins Criptococcus Fungal virulence Immune evasion pH regulation Pneumocysits Aspergillus Regulation of antifungals resistance Candida Fusarium Trehalose biosynthesis Fungal genotyping Scedosporium thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) |
| url | 33666 |
| work_keys_str_mv | AT lealfernando fungalpathogenesisinhumansthegrowingthreat |