G-quadruplex and Microorganisms
G-quadruplexes (G4s) are nucleic acids secondary structures that form in DNA or RNA guanine (G)-rich strands. In recent years, the presence of G4s in microorganisms has attracted increasing interest. In prokaryotes, G4 sequences have been reported in several human pathogens. Bacterial enzymes able t...
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| Formato: | Online |
| Idioma: | inglês |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Acesso em linha: | 42481 |
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| _version_ | 1869523580235022336 |
|---|---|
| author | Richter, Sara N. |
| author_browse | Richter, Sara N. |
| author_facet | Richter, Sara N. |
| author_sort | Richter, Sara N. |
| collection | Directory of Open Access Books |
| description | G-quadruplexes (G4s) are nucleic acids secondary structures that form in DNA or RNA guanine (G)-rich strands. In recent years, the presence of G4s in microorganisms has attracted increasing interest. In prokaryotes, G4 sequences have been reported in several human pathogens. Bacterial enzymes able to process G4s have been identified. In viruses, G4s have been suggested to be involved in key steps of the viral life cycle: They have been associated with the human immunodeficiency virus (HIV), herpes simplex virus 1 (HSV-1), human papilloma virus, swine pseudorabies virus, and other viruses’ genomes. New evidence shows the presence of G4s in parasitic protozoa, such as the causative agent of malaria. G4 binding proteins and mRNA G4s have been implicated in the regulation of microorganisms’ genome replication and translation. G4 ligands have been developed and tested both as tools to study the complexity of G4-mediated mechanisms in the viral life cycle and as therapeutic agents. Moreover, new techniques to study G4 folding and their interactions with proteins have been developed. This Special Issue will focus on G4s present in microorganisms, addressing all the above aspects. |
| format | Online |
| id | doab-20.500.12854ir-48248 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-482482024-03-31T13:09:47Z G-quadruplex and Microorganisms Richter, Sara N. R5-920 RC109-216 bacteria folding co-translational refolding RecQ helicase regulatory element conformational dynamics G4Hunter NDPK fluorescence pseudorabies virus Epstein-Barr virus (EBV) structure-activity relationship PhenDC3 eukaryotic hosts Herpesvirus translation suppression turn-on ligands co-transcriptional folding Herpesviridae G-quadruplex nucleoside diphosphate kinase nucleic acids nucleic acids conformation bioinformatics protein–DNA interaction aptamers deinococcus Alphaherpesvirinae EBNA1 G4 virus human papillomaviruses S. cerevisiae genome stability G-quadruplexes metastable structure genome evolution pyridostatin alphaherpesviruses structure protozoa genome G-quadruplex ligand NMR microbes DNA protein-mRNA interactions G-quadruplex formation immediate early promoters thema EDItEUR::M Medicine and Nursing G-quadruplexes (G4s) are nucleic acids secondary structures that form in DNA or RNA guanine (G)-rich strands. In recent years, the presence of G4s in microorganisms has attracted increasing interest. In prokaryotes, G4 sequences have been reported in several human pathogens. Bacterial enzymes able to process G4s have been identified. In viruses, G4s have been suggested to be involved in key steps of the viral life cycle: They have been associated with the human immunodeficiency virus (HIV), herpes simplex virus 1 (HSV-1), human papilloma virus, swine pseudorabies virus, and other viruses’ genomes. New evidence shows the presence of G4s in parasitic protozoa, such as the causative agent of malaria. G4 binding proteins and mRNA G4s have been implicated in the regulation of microorganisms’ genome replication and translation. G4 ligands have been developed and tested both as tools to study the complexity of G4-mediated mechanisms in the viral life cycle and as therapeutic agents. Moreover, new techniques to study G4 folding and their interactions with proteins have been developed. This Special Issue will focus on G4s present in microorganisms, addressing all the above aspects. 2021-02-11T14:14:59Z 2021-02-11T14:14:59Z 2019-12-09 11:49:15 2019 book 42481 9783039212439 9783039212446 https://directory.doabooks.org/handle/20.500.12854/48248 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/1495 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03921-244-6 10.3390/books978-3-03921-244-6 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039212439 9783039212446 208 open access |
| spellingShingle | R5-920 RC109-216 bacteria folding co-translational refolding RecQ helicase regulatory element conformational dynamics G4Hunter NDPK fluorescence pseudorabies virus Epstein-Barr virus (EBV) structure-activity relationship PhenDC3 eukaryotic hosts Herpesvirus translation suppression turn-on ligands co-transcriptional folding Herpesviridae G-quadruplex nucleoside diphosphate kinase nucleic acids nucleic acids conformation bioinformatics protein–DNA interaction aptamers deinococcus Alphaherpesvirinae EBNA1 G4 virus human papillomaviruses S. cerevisiae genome stability G-quadruplexes metastable structure genome evolution pyridostatin alphaherpesviruses structure protozoa genome G-quadruplex ligand NMR microbes DNA protein-mRNA interactions G-quadruplex formation immediate early promoters thema EDItEUR::M Medicine and Nursing Richter, Sara N. G-quadruplex and Microorganisms |
| title | G-quadruplex and Microorganisms |
| title_full | G-quadruplex and Microorganisms |
| title_fullStr | G-quadruplex and Microorganisms |
| title_full_unstemmed | G-quadruplex and Microorganisms |
| title_short | G-quadruplex and Microorganisms |
| title_sort | g quadruplex and microorganisms |
| topic | R5-920 RC109-216 bacteria folding co-translational refolding RecQ helicase regulatory element conformational dynamics G4Hunter NDPK fluorescence pseudorabies virus Epstein-Barr virus (EBV) structure-activity relationship PhenDC3 eukaryotic hosts Herpesvirus translation suppression turn-on ligands co-transcriptional folding Herpesviridae G-quadruplex nucleoside diphosphate kinase nucleic acids nucleic acids conformation bioinformatics protein–DNA interaction aptamers deinococcus Alphaherpesvirinae EBNA1 G4 virus human papillomaviruses S. cerevisiae genome stability G-quadruplexes metastable structure genome evolution pyridostatin alphaherpesviruses structure protozoa genome G-quadruplex ligand NMR microbes DNA protein-mRNA interactions G-quadruplex formation immediate early promoters thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC109-216 bacteria folding co-translational refolding RecQ helicase regulatory element conformational dynamics G4Hunter NDPK fluorescence pseudorabies virus Epstein-Barr virus (EBV) structure-activity relationship PhenDC3 eukaryotic hosts Herpesvirus translation suppression turn-on ligands co-transcriptional folding Herpesviridae G-quadruplex nucleoside diphosphate kinase nucleic acids nucleic acids conformation bioinformatics protein–DNA interaction aptamers deinococcus Alphaherpesvirinae EBNA1 G4 virus human papillomaviruses S. cerevisiae genome stability G-quadruplexes metastable structure genome evolution pyridostatin alphaherpesviruses structure protozoa genome G-quadruplex ligand NMR microbes DNA protein-mRNA interactions G-quadruplex formation immediate early promoters thema EDItEUR::M Medicine and Nursing |
| url | 42481 |
| work_keys_str_mv | AT richtersaran gquadruplexandmicroorganisms |