Gene function in schistosomes: recent advances towards a cure
Schistosomes are human parasites distributed worldwide in tropical and sub-tropical latitudes, especially in developing countries and impoverished regions. These neglected tropical disease (NTD) pathogens causes debilitating illnesses, which include hepatosplenomegaly, hepatic fibrosis, haemorrhagic...
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| Формат: | Online |
| Мова: | Англійська |
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Frontiers Media SA
2021
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| Онлайн доступ: | 18165 |
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| _version_ | 1869521219350429696 |
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| author | Arnon Dias Jurberg Paul J Brindley |
| author_browse | Arnon Dias Jurberg Paul J Brindley |
| author_facet | Arnon Dias Jurberg Paul J Brindley |
| author_sort | Arnon Dias Jurberg |
| collection | Directory of Open Access Books |
| description | Schistosomes are human parasites distributed worldwide in tropical and sub-tropical latitudes, especially in developing countries and impoverished regions. These neglected tropical disease (NTD) pathogens causes debilitating illnesses, which include hepatosplenomegaly, hepatic fibrosis, haemorrhagic necrotic ulcerations in the intestinal mucosa, urogenital tract diseases, in addition to cardiopulmonary, renal and neurologic lesions due to egg accumulation in the liver, intestines, uro-genital tissues and other sites. Urogenital schistosomiasis is a risk factor for bladder cancer and increases the risk of transmission of HIV infection. Despite extensive effort to control this NTD over the years, deployment on a considerable scale of commercially available drugs in endemic populations has induced the emergence of resistant isolates and raised the need to identify new targets for alternative therapies. Because of the availability of genomes of the three major species of human schistosomiasis, and through advances in functional genomics and live imaging, studies on schistosomes have now come into focus as models to investigate adaptations to parasitism and developmental biology of trematodes and cestodes, and indeed flatworms and Lophotrochozoans, at large. This Research Topic aims at gathering state-of-art essays on schistosome genetics, genetics, pathobiology and immunobiology. It also aims to highlight advances in understanding of the host-parasite relationship, in paradigms that address this NTD, and to discuss new perspectives and advances in chemotherapy and immunoprophylaxis. |
| format | Online |
| id | doab-20.500.12854ir-48349 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-483492024-04-05T12:35:02Z Gene function in schistosomes: recent advances towards a cure Arnon Dias Jurberg Paul J Brindley QH426-470 QR1-502 QH540-549.5 Q1-390 Schistosomiasis Schistosoma mansoni S japonicum neglected tropical diseases infection induced cancer Anthelmintic drugs S haematobium Blood fluke Vaccines Helminthiasis thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) Schistosomes are human parasites distributed worldwide in tropical and sub-tropical latitudes, especially in developing countries and impoverished regions. These neglected tropical disease (NTD) pathogens causes debilitating illnesses, which include hepatosplenomegaly, hepatic fibrosis, haemorrhagic necrotic ulcerations in the intestinal mucosa, urogenital tract diseases, in addition to cardiopulmonary, renal and neurologic lesions due to egg accumulation in the liver, intestines, uro-genital tissues and other sites. Urogenital schistosomiasis is a risk factor for bladder cancer and increases the risk of transmission of HIV infection. Despite extensive effort to control this NTD over the years, deployment on a considerable scale of commercially available drugs in endemic populations has induced the emergence of resistant isolates and raised the need to identify new targets for alternative therapies. Because of the availability of genomes of the three major species of human schistosomiasis, and through advances in functional genomics and live imaging, studies on schistosomes have now come into focus as models to investigate adaptations to parasitism and developmental biology of trematodes and cestodes, and indeed flatworms and Lophotrochozoans, at large. This Research Topic aims at gathering state-of-art essays on schistosome genetics, genetics, pathobiology and immunobiology. It also aims to highlight advances in understanding of the host-parasite relationship, in paradigms that address this NTD, and to discuss new perspectives and advances in chemotherapy and immunoprophylaxis. 2021-02-11T14:20:32Z 2021-02-11T14:20:32Z 2016-01-19 14:05:46 2015 book 18165 16648714 9782889195565 https://directory.doabooks.org/handle/20.500.12854/48349 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Gene_function_in_schistosomes_recent_advances_towards_a_cure/585#nogo http://journal.frontiersin.org/researchtopic/2094/gene-function-in-schistosomes-recent-advances-towards-a-cure Frontiers Media SA 10.3389/978-2-88919-556-5 10.3389/978-2-88919-556-5 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889195565 154 open access |
| spellingShingle | QH426-470 QR1-502 QH540-549.5 Q1-390 Schistosomiasis Schistosoma mansoni S japonicum neglected tropical diseases infection induced cancer Anthelmintic drugs S haematobium Blood fluke Vaccines Helminthiasis thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) Arnon Dias Jurberg Paul J Brindley Gene function in schistosomes: recent advances towards a cure |
| title | Gene function in schistosomes: recent advances towards a cure |
| title_full | Gene function in schistosomes: recent advances towards a cure |
| title_fullStr | Gene function in schistosomes: recent advances towards a cure |
| title_full_unstemmed | Gene function in schistosomes: recent advances towards a cure |
| title_short | Gene function in schistosomes: recent advances towards a cure |
| title_sort | gene function in schistosomes recent advances towards a cure |
| topic | QH426-470 QR1-502 QH540-549.5 Q1-390 Schistosomiasis Schistosoma mansoni S japonicum neglected tropical diseases infection induced cancer Anthelmintic drugs S haematobium Blood fluke Vaccines Helminthiasis thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) |
| topic_facet | QH426-470 QR1-502 QH540-549.5 Q1-390 Schistosomiasis Schistosoma mansoni S japonicum neglected tropical diseases infection induced cancer Anthelmintic drugs S haematobium Blood fluke Vaccines Helminthiasis thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) |
| url | 18165 |
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