Genetic Determinants of Human Longevity
In the last two decades, due to the continuous increase of lifespans in Westernsocieties, and the consequent growing of the elderly population, have witnessedan increase in the number of studies on biological and molecular factors able topromote healthy aging and reach longevity. The study of the ge...
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| Formato: | Online |
| Idioma: | inglês |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Acesso em linha: | 42609 |
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| _version_ | 1869531354450886656 |
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| author | Rose, Giuseppina Sørensen, Mette Dato, Serena |
| author_browse | Dato, Serena Rose, Giuseppina Sørensen, Mette |
| author_facet | Rose, Giuseppina Sørensen, Mette Dato, Serena |
| author_sort | Rose, Giuseppina |
| collection | Directory of Open Access Books |
| description | In the last two decades, due to the continuous increase of lifespans in Westernsocieties, and the consequent growing of the elderly population, have witnessedan increase in the number of studies on biological and molecular factors able topromote healthy aging and reach longevity. The study of the genetic componentof human longevity demonstrated that it accounts for 25% of intra populationphenotype variance. The efforts made to characterize the genetic determinantssuggested that the maintenance of cellular integrity, inflammation, oxidativestress response, DNA repair, as well as the use of nutrients, represent the mostimportant pathways correlated with a longer lifespan. However, although aplethora of variants were indicated to be associated with human longevity, onlyvery few were successfully replicated in different populations, probably becauseof population specificity, missing heritability as well as a complex interactionamong genetic factors with lifestyle and cultural factors, which modulate theindividual chance of living longer. Thus, many challenges remain to be addressedin the search for the genetic components of human longevity. This Special Issue isaimed to unify the progress in the analysis of the genetic determinants of humanlongevity, to take stock of the situation and point to future directions of the field.We invite submissions for reviews, research articles, short-communicationsdealing with genetic association studies in human longevity, including all types ofgenetic variation, as well as the characterization of longevity-related genes. |
| format | Online |
| id | doab-20.500.12854ir-48392 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-483922024-04-05T12:35:16Z Genetic Determinants of Human Longevity Rose, Giuseppina Sørensen, Mette Dato, Serena QH426-470 QH301-705.5 Q1-390 unknown zygosity exceptional longevity TERC xenobiotic-metabolizing enzymes lifespan gender-specific association long-livers polymorphism cumulative incidence curves cardiovascular health twins genetic determinants of human longevity TERT SNP moonlighting protein longevity genomics APOE polygenic risk score signal transduction xenobiotics survival IPMK genetic variation genetic association study molecular senescence zygosity longevity-related genes age-stratification lipid profile mortality apolipoprotein E aging model systems leukocyte telomere length inositol phosphates human lifespan populations thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) In the last two decades, due to the continuous increase of lifespans in Westernsocieties, and the consequent growing of the elderly population, have witnessedan increase in the number of studies on biological and molecular factors able topromote healthy aging and reach longevity. The study of the genetic componentof human longevity demonstrated that it accounts for 25% of intra populationphenotype variance. The efforts made to characterize the genetic determinantssuggested that the maintenance of cellular integrity, inflammation, oxidativestress response, DNA repair, as well as the use of nutrients, represent the mostimportant pathways correlated with a longer lifespan. However, although aplethora of variants were indicated to be associated with human longevity, onlyvery few were successfully replicated in different populations, probably becauseof population specificity, missing heritability as well as a complex interactionamong genetic factors with lifestyle and cultural factors, which modulate theindividual chance of living longer. Thus, many challenges remain to be addressedin the search for the genetic components of human longevity. This Special Issue isaimed to unify the progress in the analysis of the genetic determinants of humanlongevity, to take stock of the situation and point to future directions of the field.We invite submissions for reviews, research articles, short-communicationsdealing with genetic association studies in human longevity, including all types ofgenetic variation, as well as the characterization of longevity-related genes. 2021-02-11T14:23:27Z 2021-02-11T14:23:27Z 2019-12-09 11:49:16 2019 book 42609 9783039216796 9783039216789 https://directory.doabooks.org/handle/20.500.12854/48392 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/1752 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03921-679-6 10.3390/books978-3-03921-679-6 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039216796 9783039216789 118 open access |
| spellingShingle | QH426-470 QH301-705.5 Q1-390 unknown zygosity exceptional longevity TERC xenobiotic-metabolizing enzymes lifespan gender-specific association long-livers polymorphism cumulative incidence curves cardiovascular health twins genetic determinants of human longevity TERT SNP moonlighting protein longevity genomics APOE polygenic risk score signal transduction xenobiotics survival IPMK genetic variation genetic association study molecular senescence zygosity longevity-related genes age-stratification lipid profile mortality apolipoprotein E aging model systems leukocyte telomere length inositol phosphates human lifespan populations thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) Rose, Giuseppina Sørensen, Mette Dato, Serena Genetic Determinants of Human Longevity |
| title | Genetic Determinants of Human Longevity |
| title_full | Genetic Determinants of Human Longevity |
| title_fullStr | Genetic Determinants of Human Longevity |
| title_full_unstemmed | Genetic Determinants of Human Longevity |
| title_short | Genetic Determinants of Human Longevity |
| title_sort | genetic determinants of human longevity |
| topic | QH426-470 QH301-705.5 Q1-390 unknown zygosity exceptional longevity TERC xenobiotic-metabolizing enzymes lifespan gender-specific association long-livers polymorphism cumulative incidence curves cardiovascular health twins genetic determinants of human longevity TERT SNP moonlighting protein longevity genomics APOE polygenic risk score signal transduction xenobiotics survival IPMK genetic variation genetic association study molecular senescence zygosity longevity-related genes age-stratification lipid profile mortality apolipoprotein E aging model systems leukocyte telomere length inositol phosphates human lifespan populations thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) |
| topic_facet | QH426-470 QH301-705.5 Q1-390 unknown zygosity exceptional longevity TERC xenobiotic-metabolizing enzymes lifespan gender-specific association long-livers polymorphism cumulative incidence curves cardiovascular health twins genetic determinants of human longevity TERT SNP moonlighting protein longevity genomics APOE polygenic risk score signal transduction xenobiotics survival IPMK genetic variation genetic association study molecular senescence zygosity longevity-related genes age-stratification lipid profile mortality apolipoprotein E aging model systems leukocyte telomere length inositol phosphates human lifespan populations thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) |
| url | 42609 |
| work_keys_str_mv | AT rosegiuseppina geneticdeterminantsofhumanlongevity AT sørensenmette geneticdeterminantsofhumanlongevity AT datoserena geneticdeterminantsofhumanlongevity |