Genome Mining and Marine Microbial Natural Products
Two review papers, eight research articles, and one brief report were published in this Special Issue. They showed the rich resources that are present within the genomes of marine microorganisms and discussed the use of recently developed tools and technologies to exploit this genetic richness. Exam...
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| Main Authors: | , , |
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| Formato: | Online |
| Idioma: | inglés |
| Publicado: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Subjects: | |
| Acceso en liña: | 43618 |
| Tags: |
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| _version_ | 1869527277813891072 |
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| author | Hong, Kui Zhang, Changsheng Dobson, Alan |
| author_browse | Dobson, Alan Hong, Kui Zhang, Changsheng |
| author_facet | Hong, Kui Zhang, Changsheng Dobson, Alan |
| author_sort | Hong, Kui |
| collection | Directory of Open Access Books |
| description | Two review papers, eight research articles, and one brief report were published in this Special Issue. They showed the rich resources that are present within the genomes of marine microorganisms and discussed the use of recently developed tools and technologies to exploit this genetic richness. Examples include the rational supply of precursors according to the relevant biosynthetic pathway and stress driven discovery together with the use of histone deacetylase inhibitors to facilitate the discovery of new bioactive molecules with potential biopharmaceutical applications. We believe that the content of this Special Issue reflects the current state-of-the-art research in this area and highlights the interesting strategies that are being employed to uncover increasing numbers of exciting novel compounds for drug discovery from marine genetic resources. |
| format | Online |
| id | doab-20.500.12854ir-48415 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-484152024-04-05T12:33:22Z Genome Mining and Marine Microbial Natural Products Hong, Kui Zhang, Changsheng Dobson, Alan QH301-705.5 QR1-502 Q1-390 antibacterial activity polyketide synthase halo-extremophyles antibacterial gene cluster Penicillium chrysogenum bacillomycin secondary metabolites drug discovery biosynthesis polycyclic tetramate macrolactams actinobacteria biosynthetic gene clusters phylotype comparative genomics IclR family regulator polyketide antibiotics antifungal fatty acid amide Antarctica marine microorganisms NdgRyo nonribosomal peptides Marisediminicola genome mining antimicrobial sponge Stachybotrys carotenoid marine archaea haloenzymes natural products Streptomyces sp. SCSIO 40010 16S rRNA metagenomics ecotype medicinal chemistry cytotoxicity marine natural products (MNPs) Streptomyces marine Bacillus antimicrobial activity amino compound bacillibactin meroterpenoid fibrinolytic activity metal stress technique isoindolinone biosynthesis Streptomyces pratensis histone-deacetylase inhibitor marine natural product Odiel marshlands thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Two review papers, eight research articles, and one brief report were published in this Special Issue. They showed the rich resources that are present within the genomes of marine microorganisms and discussed the use of recently developed tools and technologies to exploit this genetic richness. Examples include the rational supply of precursors according to the relevant biosynthetic pathway and stress driven discovery together with the use of histone deacetylase inhibitors to facilitate the discovery of new bioactive molecules with potential biopharmaceutical applications. We believe that the content of this Special Issue reflects the current state-of-the-art research in this area and highlights the interesting strategies that are being employed to uncover increasing numbers of exciting novel compounds for drug discovery from marine genetic resources. 2021-02-11T14:25:52Z 2021-02-11T14:25:52Z 2020-01-30 16:39:46 2020 book 43618 9783039280919 9783039280902 https://directory.doabooks.org/handle/20.500.12854/48415 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://www.mdpi.com/books/pdfview/book/1926 https://www.mdpi.com/books/pdfview/book/1926 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03928-091-9 10.3390/books978-3-03928-091-9 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039280919 9783039280902 202 open access |
| spellingShingle | QH301-705.5 QR1-502 Q1-390 antibacterial activity polyketide synthase halo-extremophyles antibacterial gene cluster Penicillium chrysogenum bacillomycin secondary metabolites drug discovery biosynthesis polycyclic tetramate macrolactams actinobacteria biosynthetic gene clusters phylotype comparative genomics IclR family regulator polyketide antibiotics antifungal fatty acid amide Antarctica marine microorganisms NdgRyo nonribosomal peptides Marisediminicola genome mining antimicrobial sponge Stachybotrys carotenoid marine archaea haloenzymes natural products Streptomyces sp. SCSIO 40010 16S rRNA metagenomics ecotype medicinal chemistry cytotoxicity marine natural products (MNPs) Streptomyces marine Bacillus antimicrobial activity amino compound bacillibactin meroterpenoid fibrinolytic activity metal stress technique isoindolinone biosynthesis Streptomyces pratensis histone-deacetylase inhibitor marine natural product Odiel marshlands thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Hong, Kui Zhang, Changsheng Dobson, Alan Genome Mining and Marine Microbial Natural Products |
| title | Genome Mining and Marine Microbial Natural Products |
| title_full | Genome Mining and Marine Microbial Natural Products |
| title_fullStr | Genome Mining and Marine Microbial Natural Products |
| title_full_unstemmed | Genome Mining and Marine Microbial Natural Products |
| title_short | Genome Mining and Marine Microbial Natural Products |
| title_sort | genome mining and marine microbial natural products |
| topic | QH301-705.5 QR1-502 Q1-390 antibacterial activity polyketide synthase halo-extremophyles antibacterial gene cluster Penicillium chrysogenum bacillomycin secondary metabolites drug discovery biosynthesis polycyclic tetramate macrolactams actinobacteria biosynthetic gene clusters phylotype comparative genomics IclR family regulator polyketide antibiotics antifungal fatty acid amide Antarctica marine microorganisms NdgRyo nonribosomal peptides Marisediminicola genome mining antimicrobial sponge Stachybotrys carotenoid marine archaea haloenzymes natural products Streptomyces sp. SCSIO 40010 16S rRNA metagenomics ecotype medicinal chemistry cytotoxicity marine natural products (MNPs) Streptomyces marine Bacillus antimicrobial activity amino compound bacillibactin meroterpenoid fibrinolytic activity metal stress technique isoindolinone biosynthesis Streptomyces pratensis histone-deacetylase inhibitor marine natural product Odiel marshlands thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | QH301-705.5 QR1-502 Q1-390 antibacterial activity polyketide synthase halo-extremophyles antibacterial gene cluster Penicillium chrysogenum bacillomycin secondary metabolites drug discovery biosynthesis polycyclic tetramate macrolactams actinobacteria biosynthetic gene clusters phylotype comparative genomics IclR family regulator polyketide antibiotics antifungal fatty acid amide Antarctica marine microorganisms NdgRyo nonribosomal peptides Marisediminicola genome mining antimicrobial sponge Stachybotrys carotenoid marine archaea haloenzymes natural products Streptomyces sp. SCSIO 40010 16S rRNA metagenomics ecotype medicinal chemistry cytotoxicity marine natural products (MNPs) Streptomyces marine Bacillus antimicrobial activity amino compound bacillibactin meroterpenoid fibrinolytic activity metal stress technique isoindolinone biosynthesis Streptomyces pratensis histone-deacetylase inhibitor marine natural product Odiel marshlands thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | 43618 |
| work_keys_str_mv | AT hongkui genomeminingandmarinemicrobialnaturalproducts AT zhangchangsheng genomeminingandmarinemicrobialnaturalproducts AT dobsonalan genomeminingandmarinemicrobialnaturalproducts |