Genome-wide view on the physiology of vitamin D
The main physiological actions of the biologically most active metabolite of vitamin D, 1a,25-dihydroxyvitamin D3(1a,25(OH)2D3), are calcium and phosphorus uptake and transport and thereby controlling bone formation. Other emergent areas of 1a,25(OH)2D3 action are in the control of immune functions,...
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Frontiers Media SA
2021
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| Truy cập trực tuyến: | 18679 |
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| _version_ | 1869515115817074688 |
|---|---|
| author | Carsten Carlberg |
| author_browse | Carsten Carlberg |
| author_facet | Carsten Carlberg |
| author_sort | Carsten Carlberg |
| collection | Directory of Open Access Books |
| description | The main physiological actions of the biologically most active metabolite of vitamin D, 1a,25-dihydroxyvitamin D3(1a,25(OH)2D3), are calcium and phosphorus uptake and transport and thereby controlling bone formation. Other emergent areas of 1a,25(OH)2D3 action are in the control of immune functions, cellular growth and differentiation. This fits both with the widespread expression of the VDR and the above described consequences of vitamin D deficiency. Transcriptome-wide analysis indicated that per cell type between 200 and 600 genes are primary targets of vitamin D. Since most of these genes respond to vitamin D in a cell-specific fashion, the total number of vitamin D targets in the human genome is far higher than 1,000. This is supported by the genome-wide view on VDR binding sites in human lymphocytes, monocytes, colon and hepatic cells. All genomic actions of 1a,25(OH)2D3 are mediated by the transcription factor vitamin D receptor (VDR) that has been the subject of intense study since the 1980’s. Thus, vitamin D signaling primarily implies the molecular actions of the VDR. In this research topic, we present in 15 chapters different perspectives on the action of vitamin D and its receptor, such as the impact of the genomewide distribution of VDR binding loci, ii) the transcriptome- and proteome-wide effects of vitamin D, iii) the role of vitamin D in health, iv) tissue-specific functions of vitamin D and v) the involvement of vitamin D in different diseases, such as infections, autoimmune diseases, diabetes and different types of cancer. |
| format | Online |
| id | doab-20.500.12854ir-48416 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-484162024-03-31T22:45:05Z Genome-wide view on the physiology of vitamin D Carsten Carlberg QP1-981 Q1-390 Vitamin D Immune System Genomics vitamin D receptor Physiology thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology The main physiological actions of the biologically most active metabolite of vitamin D, 1a,25-dihydroxyvitamin D3(1a,25(OH)2D3), are calcium and phosphorus uptake and transport and thereby controlling bone formation. Other emergent areas of 1a,25(OH)2D3 action are in the control of immune functions, cellular growth and differentiation. This fits both with the widespread expression of the VDR and the above described consequences of vitamin D deficiency. Transcriptome-wide analysis indicated that per cell type between 200 and 600 genes are primary targets of vitamin D. Since most of these genes respond to vitamin D in a cell-specific fashion, the total number of vitamin D targets in the human genome is far higher than 1,000. This is supported by the genome-wide view on VDR binding sites in human lymphocytes, monocytes, colon and hepatic cells. All genomic actions of 1a,25(OH)2D3 are mediated by the transcription factor vitamin D receptor (VDR) that has been the subject of intense study since the 1980’s. Thus, vitamin D signaling primarily implies the molecular actions of the VDR. In this research topic, we present in 15 chapters different perspectives on the action of vitamin D and its receptor, such as the impact of the genomewide distribution of VDR binding loci, ii) the transcriptome- and proteome-wide effects of vitamin D, iii) the role of vitamin D in health, iv) tissue-specific functions of vitamin D and v) the involvement of vitamin D in different diseases, such as infections, autoimmune diseases, diabetes and different types of cancer. 2021-02-11T14:25:54Z 2021-02-11T14:25:54Z 2016-03-10 08:14:32 2014 book 18679 16648714 9782889193493 https://directory.doabooks.org/handle/20.500.12854/48416 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Genome-wide_view_on_the_physiology_of_vitamin_D/389 http://journal.frontiersin.org/researchtopic/2090/genome-wide-view-on-the-physiology-of-vitamin-d Frontiers Media SA 10.3389/978-2-88919-349-3 10.3389/978-2-88919-349-3 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889193493 194 open access |
| spellingShingle | QP1-981 Q1-390 Vitamin D Immune System Genomics vitamin D receptor Physiology thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology Carsten Carlberg Genome-wide view on the physiology of vitamin D |
| title | Genome-wide view on the physiology of vitamin D |
| title_full | Genome-wide view on the physiology of vitamin D |
| title_fullStr | Genome-wide view on the physiology of vitamin D |
| title_full_unstemmed | Genome-wide view on the physiology of vitamin D |
| title_short | Genome-wide view on the physiology of vitamin D |
| title_sort | genome wide view on the physiology of vitamin d |
| topic | QP1-981 Q1-390 Vitamin D Immune System Genomics vitamin D receptor Physiology thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| topic_facet | QP1-981 Q1-390 Vitamin D Immune System Genomics vitamin D receptor Physiology thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| url | 18679 |
| work_keys_str_mv | AT carstencarlberg genomewideviewonthephysiologyofvitamind |