Glial Plasticity in Depression
Major depression is a highly prevalent disorder that poses a significant social burden in society nowadays. The pathophysiology of this disease is still poorly understood but growing evidence suggests that impaired neuron and glial plasticity may be a key underlying mechanism for the precipitation o...
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| Formaat: | Online |
| Taal: | Engels |
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Frontiers Media SA
2021
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| Online toegang: | 18386 |
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| _version_ | 1869516990474878976 |
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| author | Luisa Pinto Nuno Sousa Joao F. Oliveira Catarina A. Gomes Sandra H. Vaz |
| author_browse | Catarina A. Gomes Joao F. Oliveira Luisa Pinto Nuno Sousa Sandra H. Vaz |
| author_facet | Luisa Pinto Nuno Sousa Joao F. Oliveira Catarina A. Gomes Sandra H. Vaz |
| author_sort | Luisa Pinto |
| collection | Directory of Open Access Books |
| description | Major depression is a highly prevalent disorder that poses a significant social burden in society nowadays. The pathophysiology of this disease is still poorly understood but growing evidence suggests that impaired neuron and glial plasticity may be a key underlying mechanism for the precipitation of the disorder. One of the most surprising findings in this field was the involvement of glial cells in the pathophysiology of major depression and in the action of antidepressants, namely in mechanisms related with adult neurogenesis imbalances or dendritic arborization impairments. In particular, several works refer to alterations in the morphology and numbers of astrocytes, microglia and oligodendrocytes in the context of depression in human patients or animal models of depression. These observations were linked to functional evidences and suggested to underlie the pathophysiology of depression. Among others, these include impairments in the cross-talk between glia and neurons, changes in the level of neurotransmitter or immunoactive substances, myelination status, synapse formation, maintenance, or elimination. In addition to the implication of glia in the pathophysiology of depression, a number of studies is ascribing glia pathways to classically accepted antidepressant mechanisms. Therefore, it is noteworthy to elucidate the role of glia in the effect provided by antidepressant treatment in order to better understand secondary effects and elucidate alternative targets for treatment. |
| format | Online |
| id | doab-20.500.12854ir-48665 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-486652024-04-05T12:35:44Z Glial Plasticity in Depression Luisa Pinto Nuno Sousa Joao F. Oliveira Catarina A. Gomes Sandra H. Vaz RC321-571 Q1-390 Neuron oligodendrocyte antidepressant Depression astrocyte Microglia thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Major depression is a highly prevalent disorder that poses a significant social burden in society nowadays. The pathophysiology of this disease is still poorly understood but growing evidence suggests that impaired neuron and glial plasticity may be a key underlying mechanism for the precipitation of the disorder. One of the most surprising findings in this field was the involvement of glial cells in the pathophysiology of major depression and in the action of antidepressants, namely in mechanisms related with adult neurogenesis imbalances or dendritic arborization impairments. In particular, several works refer to alterations in the morphology and numbers of astrocytes, microglia and oligodendrocytes in the context of depression in human patients or animal models of depression. These observations were linked to functional evidences and suggested to underlie the pathophysiology of depression. Among others, these include impairments in the cross-talk between glia and neurons, changes in the level of neurotransmitter or immunoactive substances, myelination status, synapse formation, maintenance, or elimination. In addition to the implication of glia in the pathophysiology of depression, a number of studies is ascribing glia pathways to classically accepted antidepressant mechanisms. Therefore, it is noteworthy to elucidate the role of glia in the effect provided by antidepressant treatment in order to better understand secondary effects and elucidate alternative targets for treatment. 2021-02-11T14:39:19Z 2021-02-11T14:39:19Z 2016-01-19 14:05:46 2016 book 18386 16648714 9782889199990 https://directory.doabooks.org/handle/20.500.12854/48665 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Glial_Plasticity_in_Depression/1037 http://journal.frontiersin.org/researchtopic/3264/glial-plasticity-in-depression Frontiers Media SA 10.3389/978-2-88919-999-0 10.3389/978-2-88919-999-0 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889199990 99 open access |
| spellingShingle | RC321-571 Q1-390 Neuron oligodendrocyte antidepressant Depression astrocyte Microglia thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Luisa Pinto Nuno Sousa Joao F. Oliveira Catarina A. Gomes Sandra H. Vaz Glial Plasticity in Depression |
| title | Glial Plasticity in Depression |
| title_full | Glial Plasticity in Depression |
| title_fullStr | Glial Plasticity in Depression |
| title_full_unstemmed | Glial Plasticity in Depression |
| title_short | Glial Plasticity in Depression |
| title_sort | glial plasticity in depression |
| topic | RC321-571 Q1-390 Neuron oligodendrocyte antidepressant Depression astrocyte Microglia thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 Neuron oligodendrocyte antidepressant Depression astrocyte Microglia thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 18386 |
| work_keys_str_mv | AT luisapinto glialplasticityindepression AT nunosousa glialplasticityindepression AT joaofoliveira glialplasticityindepression AT catarinaagomes glialplasticityindepression AT sandrahvaz glialplasticityindepression |