Glycosaminoglycans and Proteoglycans
Proteoglycans (PGs) are glycoconjugates in which a protein or peptide core is substituted with polysaccharide chains known as glycosaminoglycans (GAGs). The GAG sidechains carry a significant proportion of the functionality of PGs, interacting with many proteins to form structural units in the extra...
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| Κύριος συγγραφέας: | |
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| Μορφή: | Online |
| Γλώσσα: | Αγγλικά |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Θέματα: | |
| Διαθέσιμο Online: | 27255 |
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| _version_ | 1869519900823781376 |
|---|---|
| author | Barbara Mulloy (Ed.) |
| author_browse | Barbara Mulloy (Ed.) |
| author_facet | Barbara Mulloy (Ed.) |
| author_sort | Barbara Mulloy (Ed.) |
| collection | Directory of Open Access Books |
| description | Proteoglycans (PGs) are glycoconjugates in which a protein or peptide core is substituted with polysaccharide chains known as glycosaminoglycans (GAGs). The GAG sidechains carry a significant proportion of the functionality of PGs, interacting with many proteins to form structural units in the extracellular matrix and to modulate the transport and signalling of small proteins acting as morphogens, growth factors and cytokines. Purified GAGs such as heparin and hyaluronan are in common use as therapeutic agents, with many more PG-based natural products, synthetic and semi-synthetic mimetics on the way; in addition, potential therapeutic strategies involving PG/GAG biosynthesis and degradation as targets are currently in development. |
| format | Online |
| id | doab-20.500.12854ir-48726 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-487262024-04-01T14:14:54Z Glycosaminoglycans and Proteoglycans Barbara Mulloy (Ed.) RM1-950 heparin hyauronan keratan chondroitin glycosaminoglycan dermatan proteoglycan thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Proteoglycans (PGs) are glycoconjugates in which a protein or peptide core is substituted with polysaccharide chains known as glycosaminoglycans (GAGs). The GAG sidechains carry a significant proportion of the functionality of PGs, interacting with many proteins to form structural units in the extracellular matrix and to modulate the transport and signalling of small proteins acting as morphogens, growth factors and cytokines. Purified GAGs such as heparin and hyaluronan are in common use as therapeutic agents, with many more PG-based natural products, synthetic and semi-synthetic mimetics on the way; in addition, potential therapeutic strategies involving PG/GAG biosynthesis and degradation as targets are currently in development. 2021-02-11T14:43:30Z 2021-02-11T14:43:30Z 2018-07-04 13:46:48 2018 book 27255 9783038428367 9783038428350 https://directory.doabooks.org/handle/20.500.12854/48726 eng image/png Attribution-NonCommercial-NoDerivatives 4.0 International http://www.mdpi.com/books/pdfview/book/665 http://www.mdpi.com/books/pdfview/book/665 MDPI - Multidisciplinary Digital Publishing Institute 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783038428367 9783038428350 XVI, 230 open access |
| spellingShingle | RM1-950 heparin hyauronan keratan chondroitin glycosaminoglycan dermatan proteoglycan thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Barbara Mulloy (Ed.) Glycosaminoglycans and Proteoglycans |
| title | Glycosaminoglycans and Proteoglycans |
| title_full | Glycosaminoglycans and Proteoglycans |
| title_fullStr | Glycosaminoglycans and Proteoglycans |
| title_full_unstemmed | Glycosaminoglycans and Proteoglycans |
| title_short | Glycosaminoglycans and Proteoglycans |
| title_sort | glycosaminoglycans and proteoglycans |
| topic | RM1-950 heparin hyauronan keratan chondroitin glycosaminoglycan dermatan proteoglycan thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| topic_facet | RM1-950 heparin hyauronan keratan chondroitin glycosaminoglycan dermatan proteoglycan thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| url | 27255 |
| work_keys_str_mv | AT barbaramulloyed glycosaminoglycansandproteoglycans |