Grappling with the Multifaceted World of the DNA Damage Response
DNA damage is a major threat to genomic integrity and cell survival. It can arise both spontaneously and in response to exogenous agents. DNA damage can attack most parts of the DNA structure, ranging from minor and major chemical modifications, to single-strand breaks (SSBs) and gaps, to full doubl...
I tiakina i:
| Kaituhi matua: | |
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| Hōputu: | Online |
| Reo: | Ingarihi |
| I whakaputaina: |
Frontiers Media SA
2021
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| Ngā marau: | |
| Urunga tuihono: | 22910 |
| Ngā Tūtohu: |
Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!
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| _version_ | 1869513945895665664 |
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| author | Antonio Porro |
| author_browse | Antonio Porro |
| author_facet | Antonio Porro |
| author_sort | Antonio Porro |
| collection | Directory of Open Access Books |
| description | DNA damage is a major threat to genomic integrity and cell survival. It can arise both spontaneously and in response to exogenous agents. DNA damage can attack most parts of the DNA structure, ranging from minor and major chemical modifications, to single-strand breaks (SSBs) and gaps, to full double-strand breaks (DSBs). If DNA injuries are mis-repaired or unrepaired, they may ultimately result in mutations or wider-scale genome aberrations that threaten cell homeostasis. Consequently, the cells elicit an elaborate signalling network, known as DNA damage response (DDR), to detect and repair these cytotoxic lesions. This Research Topic was aimed at comprehensive investigations of basic and novel mechanisms that underlie the DNA damage response in eukaryotes.DNA damage is a major threat to genomic integrity and cell survival. It can arise both spontaneously and in response to exogenous agents. DNA damage can attack most parts of the DNA structure, ranging from minor and major chemical modifications, to single-strand breaks (SSBs) and gaps, to full double-strand breaks (DSBs). If DNA injuries are mis-repaired or unrepaired, they may ultimately result in mutations or wider-scale genome aberrations that threaten cell homeostasis. Consequently, the cells elicit an elaborate signalling network, known as DNA damage response (DDR), to detect and repair these cytotoxic lesions. This Research Topic was aimed at comprehensive investigations of basic and novel mechanisms that underlie the DNA damage response in eukaryotes. |
| format | Online |
| id | doab-20.500.12854ir-48864 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-488642024-04-05T12:34:52Z Grappling with the Multifaceted World of the DNA Damage Response Antonio Porro QH426-470 Q1-390 genome instability DNA damage response DNA Repair Genome integrity DNA Damage thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) DNA damage is a major threat to genomic integrity and cell survival. It can arise both spontaneously and in response to exogenous agents. DNA damage can attack most parts of the DNA structure, ranging from minor and major chemical modifications, to single-strand breaks (SSBs) and gaps, to full double-strand breaks (DSBs). If DNA injuries are mis-repaired or unrepaired, they may ultimately result in mutations or wider-scale genome aberrations that threaten cell homeostasis. Consequently, the cells elicit an elaborate signalling network, known as DNA damage response (DDR), to detect and repair these cytotoxic lesions. This Research Topic was aimed at comprehensive investigations of basic and novel mechanisms that underlie the DNA damage response in eukaryotes.DNA damage is a major threat to genomic integrity and cell survival. It can arise both spontaneously and in response to exogenous agents. DNA damage can attack most parts of the DNA structure, ranging from minor and major chemical modifications, to single-strand breaks (SSBs) and gaps, to full double-strand breaks (DSBs). If DNA injuries are mis-repaired or unrepaired, they may ultimately result in mutations or wider-scale genome aberrations that threaten cell homeostasis. Consequently, the cells elicit an elaborate signalling network, known as DNA damage response (DDR), to detect and repair these cytotoxic lesions. This Research Topic was aimed at comprehensive investigations of basic and novel mechanisms that underlie the DNA damage response in eukaryotes. 2021-02-11T14:52:13Z 2021-02-11T14:52:13Z 2017-07-06 13:27:36 2017 book 22910 16648714 9782889450572 https://directory.doabooks.org/handle/20.500.12854/48864 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Grappling_with_the_Multifaceted_World_of_the_DNA_Damage_Response/1085 http://journal.frontiersin.org/researchtopic/916/grappling-with-the-multifaceted-world-of-the-dna-damage-response Frontiers Media SA 10.3389/978-2-88945-057-2 10.3389/978-2-88945-057-2 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889450572 306 open access |
| spellingShingle | QH426-470 Q1-390 genome instability DNA damage response DNA Repair Genome integrity DNA Damage thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) Antonio Porro Grappling with the Multifaceted World of the DNA Damage Response |
| title | Grappling with the Multifaceted World of the DNA Damage Response |
| title_full | Grappling with the Multifaceted World of the DNA Damage Response |
| title_fullStr | Grappling with the Multifaceted World of the DNA Damage Response |
| title_full_unstemmed | Grappling with the Multifaceted World of the DNA Damage Response |
| title_short | Grappling with the Multifaceted World of the DNA Damage Response |
| title_sort | grappling with the multifaceted world of the dna damage response |
| topic | QH426-470 Q1-390 genome instability DNA damage response DNA Repair Genome integrity DNA Damage thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) |
| topic_facet | QH426-470 Q1-390 genome instability DNA damage response DNA Repair Genome integrity DNA Damage thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) |
| url | 22910 |
| work_keys_str_mv | AT antonioporro grapplingwiththemultifacetedworldofthednadamageresponse |