Histamine H4 receptor. A Novel Drug Target For Immunoregulation and Inflammation
H4R is the newest member of the histamine receptor family, which was discovered about twelve years ago. It is considered a very promising drug target. The effort to improve the pharmacokinetic properties of the currently available H4R ligands is reflected in a steadily growing number of scientific p...
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| Formato: | Online |
| Idioma: | inglês |
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De Gruyter
2021
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| Acesso em linha: | 15911 |
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| _version_ | 1869530691872489472 |
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| author | Stark, Holger |
| author_browse | Stark, Holger |
| author_facet | Stark, Holger |
| author_sort | Stark, Holger |
| collection | Directory of Open Access Books |
| description | H4R is the newest member of the histamine receptor family, which was discovered about twelve years ago. It is considered a very promising drug target. The effort to improve the pharmacokinetic properties of the currently available H4R ligands is reflected in a steadily growing number of scientific publications and patent applications. Preclinical data strongly confirms the need for novel potent H4R ligands to explore their therapeutic value in allergy, inflammation, autoimmune disorders, and possibly, cancer. Readers will be provided with extensive knowledge on histamine metabolism, as well as cellular histamine transport, storage and release, effects of histamine and histamine receptor ligands, with particular attention to the H4R, on inflammatory cells including mast cells, basophils, eosinophils, neutrophils, macrophages, dendritic cells, and T cells. The present knowledge on the regulatory role of histamine and the therapeutic exploitation of histamine receptor ligands in atopic diseases, with emphasis on human and animal models of asthma, allergic dermatitis and pruritus are discussed. |
| format | Online |
| id | doab-20.500.12854ir-49317 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | De Gruyter |
| publisherStr | De Gruyter |
| record_format | ojs |
| spelling | doab-20.500.12854ir-493172024-04-05T17:30:51Z Histamine H4 receptor. A Novel Drug Target For Immunoregulation and Inflammation Stark, Holger QD415-436 Allergy Inflammation Pruritus Asthma Drug Target Biogenic Amin G protein coupled receptors H4R ligands Drug Development Clinical Candidates Autoimmune Disorders Cancer thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry H4R is the newest member of the histamine receptor family, which was discovered about twelve years ago. It is considered a very promising drug target. The effort to improve the pharmacokinetic properties of the currently available H4R ligands is reflected in a steadily growing number of scientific publications and patent applications. Preclinical data strongly confirms the need for novel potent H4R ligands to explore their therapeutic value in allergy, inflammation, autoimmune disorders, and possibly, cancer. Readers will be provided with extensive knowledge on histamine metabolism, as well as cellular histamine transport, storage and release, effects of histamine and histamine receptor ligands, with particular attention to the H4R, on inflammatory cells including mast cells, basophils, eosinophils, neutrophils, macrophages, dendritic cells, and T cells. The present knowledge on the regulatory role of histamine and the therapeutic exploitation of histamine receptor ligands in atopic diseases, with emphasis on human and animal models of asthma, allergic dermatitis and pruritus are discussed. 2021-02-11T15:19:26Z 2021-02-11T15:19:26Z 2014-03-05 13:31:51 2013 book 15911 9788376560564 https://directory.doabooks.org/handle/20.500.12854/49317 eng image/jpeg Attribution-NonCommercial-NoDerivatives 4.0 International https://doi.org/10.2478/9788376560564 De Gruyter 10.2478/9788376560564 10.2478/9788376560564 af2fbfcc-ee87-43d8-a035-afb9d7eef6a5 9788376560564 368 open access |
| spellingShingle | QD415-436 Allergy Inflammation Pruritus Asthma Drug Target Biogenic Amin G protein coupled receptors H4R ligands Drug Development Clinical Candidates Autoimmune Disorders Cancer thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry Stark, Holger Histamine H4 receptor. A Novel Drug Target For Immunoregulation and Inflammation |
| title | Histamine H4 receptor. A Novel Drug Target For Immunoregulation and Inflammation |
| title_full | Histamine H4 receptor. A Novel Drug Target For Immunoregulation and Inflammation |
| title_fullStr | Histamine H4 receptor. A Novel Drug Target For Immunoregulation and Inflammation |
| title_full_unstemmed | Histamine H4 receptor. A Novel Drug Target For Immunoregulation and Inflammation |
| title_short | Histamine H4 receptor. A Novel Drug Target For Immunoregulation and Inflammation |
| title_sort | histamine h4 receptor a novel drug target for immunoregulation and inflammation |
| topic | QD415-436 Allergy Inflammation Pruritus Asthma Drug Target Biogenic Amin G protein coupled receptors H4R ligands Drug Development Clinical Candidates Autoimmune Disorders Cancer thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry |
| topic_facet | QD415-436 Allergy Inflammation Pruritus Asthma Drug Target Biogenic Amin G protein coupled receptors H4R ligands Drug Development Clinical Candidates Autoimmune Disorders Cancer thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry |
| url | 15911 |
| work_keys_str_mv | AT starkholger histamineh4receptoranoveldrugtargetforimmunoregulationandinflammation |