HIV-Induced Damage of B Cells and Production of HIV Neutralizing Antibodies
Multiple dysfunctions take place in the B cell compartment during HIV-1 infection, comprising depletion of resting memory B cells carrying serological memory to vaccines and previously met pathogens. In addition, population of B cells characterized by the expression of exhaustion markers are enlarge...
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Frontiers Media SA
2021
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| Online Access: | 29690 |
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| author | Francesca Chiodi Gabriella Scarlatti |
| author_browse | Francesca Chiodi Gabriella Scarlatti |
| author_facet | Francesca Chiodi Gabriella Scarlatti |
| author_sort | Francesca Chiodi |
| collection | Directory of Open Access Books |
| description | Multiple dysfunctions take place in the B cell compartment during HIV-1 infection, comprising depletion of resting memory B cells carrying serological memory to vaccines and previously met pathogens. In addition, population of B cells characterized by the expression of exhaustion markers are enlarged during HIV-1 infection. Antibodies with the capacity to neutralize a broad range of HIV-1 isolates can be detected only in a minority of infected patients, after a year or more from acute infection. An open question is whether the inability of producing neutralizing HIV-1 antibodies is somehow linked to the B cell immunopathology observed in patients. In this research topic we invited scientists to summarize the current state of knowledge on regulation and development of B cells and antibody responses during HIV-1 infection; fifteen contributions were received comprising both reviews and original articles. The articles are related to B cell dysfunctions identified in HIV-1 infected individuals, production of different types of antibodies (neutralizing versus non neutralizing, and of different isotypes) in vivo during HIV-1 infection and the biological factors which may impact on this process, clinical potential and applications of anti-HIV antibodies and how to achieve neutralizing antibody responses to HIV-1 epitopes upon vaccination. The topic has gathered articles on front-line research undertaken in the field of B cells and antibodies in HIV-1 infection. It is our hope that the collection of articles presented in this book may be useful for new and experienced scholars in the field and add a piece to the complex puzzle of knowledge needed for the development of an HIV-1 vaccine. |
| format | Online |
| id | doab-20.500.12854ir-49485 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
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| spelling | doab-20.500.12854ir-494852024-03-30T23:23:04Z HIV-Induced Damage of B Cells and Production of HIV Neutralizing Antibodies Francesca Chiodi Gabriella Scarlatti R5-920 RC581-607 auto-antibodies to CCR5 BAFF Gene Expression clinical potential of HIV-1 antibodies mucosal IgA responses FcRL4 neutralizing and non neutralizing HIV-1 antibodies HIV-1 vaccine targets B cells CXCL13 maternal HIV antibodies thema EDItEUR::M Medicine and Nursing Multiple dysfunctions take place in the B cell compartment during HIV-1 infection, comprising depletion of resting memory B cells carrying serological memory to vaccines and previously met pathogens. In addition, population of B cells characterized by the expression of exhaustion markers are enlarged during HIV-1 infection. Antibodies with the capacity to neutralize a broad range of HIV-1 isolates can be detected only in a minority of infected patients, after a year or more from acute infection. An open question is whether the inability of producing neutralizing HIV-1 antibodies is somehow linked to the B cell immunopathology observed in patients. In this research topic we invited scientists to summarize the current state of knowledge on regulation and development of B cells and antibody responses during HIV-1 infection; fifteen contributions were received comprising both reviews and original articles. The articles are related to B cell dysfunctions identified in HIV-1 infected individuals, production of different types of antibodies (neutralizing versus non neutralizing, and of different isotypes) in vivo during HIV-1 infection and the biological factors which may impact on this process, clinical potential and applications of anti-HIV antibodies and how to achieve neutralizing antibody responses to HIV-1 epitopes upon vaccination. The topic has gathered articles on front-line research undertaken in the field of B cells and antibodies in HIV-1 infection. It is our hope that the collection of articles presented in this book may be useful for new and experienced scholars in the field and add a piece to the complex puzzle of knowledge needed for the development of an HIV-1 vaccine. 2021-02-11T15:28:07Z 2021-02-11T15:28:07Z 2018-11-16 17:17:57 2018 book 29690 16648714 9782889454617 https://directory.doabooks.org/handle/20.500.12854/49485 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/5357/hiv-induced-damage-of-b-cells-and-production-of-hiv-neutralizing-antibodies Frontiers Media SA 10.3389/978-2-88945-461-7 10.3389/978-2-88945-461-7 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889454617 171 open access |
| spellingShingle | R5-920 RC581-607 auto-antibodies to CCR5 BAFF Gene Expression clinical potential of HIV-1 antibodies mucosal IgA responses FcRL4 neutralizing and non neutralizing HIV-1 antibodies HIV-1 vaccine targets B cells CXCL13 maternal HIV antibodies thema EDItEUR::M Medicine and Nursing Francesca Chiodi Gabriella Scarlatti HIV-Induced Damage of B Cells and Production of HIV Neutralizing Antibodies |
| title | HIV-Induced Damage of B Cells and Production of HIV Neutralizing Antibodies |
| title_full | HIV-Induced Damage of B Cells and Production of HIV Neutralizing Antibodies |
| title_fullStr | HIV-Induced Damage of B Cells and Production of HIV Neutralizing Antibodies |
| title_full_unstemmed | HIV-Induced Damage of B Cells and Production of HIV Neutralizing Antibodies |
| title_short | HIV-Induced Damage of B Cells and Production of HIV Neutralizing Antibodies |
| title_sort | hiv induced damage of b cells and production of hiv neutralizing antibodies |
| topic | R5-920 RC581-607 auto-antibodies to CCR5 BAFF Gene Expression clinical potential of HIV-1 antibodies mucosal IgA responses FcRL4 neutralizing and non neutralizing HIV-1 antibodies HIV-1 vaccine targets B cells CXCL13 maternal HIV antibodies thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC581-607 auto-antibodies to CCR5 BAFF Gene Expression clinical potential of HIV-1 antibodies mucosal IgA responses FcRL4 neutralizing and non neutralizing HIV-1 antibodies HIV-1 vaccine targets B cells CXCL13 maternal HIV antibodies thema EDItEUR::M Medicine and Nursing |
| url | 29690 |
| work_keys_str_mv | AT francescachiodi hivinduceddamageofbcellsandproductionofhivneutralizingantibodies AT gabriellascarlatti hivinduceddamageofbcellsandproductionofhivneutralizingantibodies |