Homeostatic and retrograde signaling mechanisms modulating presynaptic function and plasticity
Activity within neural circuits shapes the synaptic properties of component neurons in a manner that maintains stable excitatory drive, a process referred to as homeostatic plasticity. These potent and adaptive mechanisms have been demonstrated to modulate activity at the level of an individual neur...
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2021
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| author | Michael A. Sutton Dion Dickman Jaichandar Subramanian |
| author_browse | Dion Dickman Jaichandar Subramanian Michael A. Sutton |
| author_facet | Michael A. Sutton Dion Dickman Jaichandar Subramanian |
| author_sort | Michael A. Sutton |
| collection | Directory of Open Access Books |
| description | Activity within neural circuits shapes the synaptic properties of component neurons in a manner that maintains stable excitatory drive, a process referred to as homeostatic plasticity. These potent and adaptive mechanisms have been demonstrated to modulate activity at the level of an individual neuron, synapse, circuit, or entire network, and dysregulation at some or all of these levels may contribute to neuropsychiatric disorders, intellectual disability, and epilepsy. Greater mechanistic understanding of homeostatic plasticity will provide key insights into the etiology of these disorders, which may result from network instability and synaptic dysfunction. Over the past 15 years, the molecular mechanisms of this form of plasticity have been intensely studied in various model organisms, including invertebrates and vertebrates. Though once thought to have a predominantly postsynaptic basis, emerging evidence suggests that homeostatic mechanisms act on both sides of the synapse through mechanisms such as retrograde signaling, to orchestrate compensatory adaptations that maintain stable network function. These trans-synaptic signaling systems ultimately alter neurotransmitter release probability by a variety of mechanisms including changes in vesicle pool size and calcium influx. These adaptations are not expected to occur homogenously at all terminals of a pre-synaptic neuron, as they might synapse with neurons in non-overlapping circuits. However, the factors that govern the homeostatic control of synapse-specific plasticity are only beginning to be understood. In addition to our limited molecular understanding of pre-synaptic homeostatic plasticity, very little is known about its prevalence in vivo or its physiological and disease relevance. In this research topic, we aim to fill the aforementioned void by covering a broad range of topics that include: - Identification of signaling pathways and mechanisms that operate globally or locally to induce specific pre-synaptic adaptations - The nature of pre-synaptic ion channels relevant to this form of plasticity and their synapse-specific modulation and trafficking - Development and utilization of new tools or methods to study homeostatic plasticity in axons and pre-synaptic terminals - Novel mechanisms of homeostatic adaptations in pre-synaptic neurons - Postsynaptic sensors of activity and retrograde synaptic signaling systems - A comprehensive analysis of the kinds of pre-synaptic adaptations in diverse neural circuits and cell types - Identification of physiological or developmental conditions that promote pre-synaptic homeostatic adaptations - How activity-dependent (Hebbian) and homeostatic synaptic changes are integrated to both permit sufficient flexibility and maintain stable activity - Relevance of pre-synaptic homeostatic plasticity to the etiology of neuropsychiatric disorders - Computational modeling of pre-synaptic homeostatic plasticity and network stability. |
| format | Online |
| id | doab-20.500.12854ir-49519 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
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| publisherStr | Frontiers Media SA |
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| spelling | doab-20.500.12854ir-495192024-04-05T12:35:55Z Homeostatic and retrograde signaling mechanisms modulating presynaptic function and plasticity Michael A. Sutton Dion Dickman Jaichandar Subramanian RC321-571 Q1-390 homeostatic plasticity retrograde signaling Neurological Disease Presynaptic adaptation neurotransmitter release thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Activity within neural circuits shapes the synaptic properties of component neurons in a manner that maintains stable excitatory drive, a process referred to as homeostatic plasticity. These potent and adaptive mechanisms have been demonstrated to modulate activity at the level of an individual neuron, synapse, circuit, or entire network, and dysregulation at some or all of these levels may contribute to neuropsychiatric disorders, intellectual disability, and epilepsy. Greater mechanistic understanding of homeostatic plasticity will provide key insights into the etiology of these disorders, which may result from network instability and synaptic dysfunction. Over the past 15 years, the molecular mechanisms of this form of plasticity have been intensely studied in various model organisms, including invertebrates and vertebrates. Though once thought to have a predominantly postsynaptic basis, emerging evidence suggests that homeostatic mechanisms act on both sides of the synapse through mechanisms such as retrograde signaling, to orchestrate compensatory adaptations that maintain stable network function. These trans-synaptic signaling systems ultimately alter neurotransmitter release probability by a variety of mechanisms including changes in vesicle pool size and calcium influx. These adaptations are not expected to occur homogenously at all terminals of a pre-synaptic neuron, as they might synapse with neurons in non-overlapping circuits. However, the factors that govern the homeostatic control of synapse-specific plasticity are only beginning to be understood. In addition to our limited molecular understanding of pre-synaptic homeostatic plasticity, very little is known about its prevalence in vivo or its physiological and disease relevance. In this research topic, we aim to fill the aforementioned void by covering a broad range of topics that include: - Identification of signaling pathways and mechanisms that operate globally or locally to induce specific pre-synaptic adaptations - The nature of pre-synaptic ion channels relevant to this form of plasticity and their synapse-specific modulation and trafficking - Development and utilization of new tools or methods to study homeostatic plasticity in axons and pre-synaptic terminals - Novel mechanisms of homeostatic adaptations in pre-synaptic neurons - Postsynaptic sensors of activity and retrograde synaptic signaling systems - A comprehensive analysis of the kinds of pre-synaptic adaptations in diverse neural circuits and cell types - Identification of physiological or developmental conditions that promote pre-synaptic homeostatic adaptations - How activity-dependent (Hebbian) and homeostatic synaptic changes are integrated to both permit sufficient flexibility and maintain stable activity - Relevance of pre-synaptic homeostatic plasticity to the etiology of neuropsychiatric disorders - Computational modeling of pre-synaptic homeostatic plasticity and network stability. 2021-02-11T15:31:11Z 2021-02-11T15:31:11Z 2016-04-07 11:22:02 2016 book 18827 16648714 9782889197040 https://directory.doabooks.org/handle/20.500.12854/49519 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Homeostatic_and_Retrograde_Signaling_Mechanisms_Modulating_Presynaptic_Function_and_Plasticity/758 http://journal.frontiersin.org/researchtopic/1199/homeostatic-and-retrograde-signaling-mechanisms-modulating-presynaptic-function-and-plasticity Frontiers Media SA 10.3389/978-2-88919-704-0 10.3389/978-2-88919-704-0 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889197040 152 open access |
| spellingShingle | RC321-571 Q1-390 homeostatic plasticity retrograde signaling Neurological Disease Presynaptic adaptation neurotransmitter release thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Michael A. Sutton Dion Dickman Jaichandar Subramanian Homeostatic and retrograde signaling mechanisms modulating presynaptic function and plasticity |
| title | Homeostatic and retrograde signaling mechanisms modulating presynaptic function and plasticity |
| title_full | Homeostatic and retrograde signaling mechanisms modulating presynaptic function and plasticity |
| title_fullStr | Homeostatic and retrograde signaling mechanisms modulating presynaptic function and plasticity |
| title_full_unstemmed | Homeostatic and retrograde signaling mechanisms modulating presynaptic function and plasticity |
| title_short | Homeostatic and retrograde signaling mechanisms modulating presynaptic function and plasticity |
| title_sort | homeostatic and retrograde signaling mechanisms modulating presynaptic function and plasticity |
| topic | RC321-571 Q1-390 homeostatic plasticity retrograde signaling Neurological Disease Presynaptic adaptation neurotransmitter release thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 homeostatic plasticity retrograde signaling Neurological Disease Presynaptic adaptation neurotransmitter release thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 18827 |
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