How Salmonella infection can inform on mechanisms of immune function and homeostasis
The use of model antigens such as haptens and ovalbumin has provided enormous insights into how immune responses develop, particularly to vaccine antigens. Furthermore, these studies are overwhelmingly performed in animals housed in clean facilities and are not known to have experienced overt clinic...
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| Formato: | Online |
| Idioma: | inglês |
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Frontiers Media SA
2021
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| Acesso em linha: | 20292 |
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| author | Constantino Lopez-Macias Adam Cunningham |
| author_browse | Adam Cunningham Constantino Lopez-Macias |
| author_facet | Constantino Lopez-Macias Adam Cunningham |
| author_sort | Constantino Lopez-Macias |
| collection | Directory of Open Access Books |
| description | The use of model antigens such as haptens and ovalbumin has provided enormous insights into how immune responses develop, particularly to vaccine antigens. Furthermore, these studies are overwhelmingly performed in animals housed in clean facilities and are not known to have experienced overt clinical signs caused by infectious agents. Therefore, this is unlikely to reflect the impact more complex host-pathogen interactions can have on the host, nor the diversity in how immunity is regulated. Humans develop immune responses in the context of the periodic exposure to multiple pathogens and vaccines over a life-time. These are likely to have a long-lasting effect on who and what we are and how we respond to further antigen challenge. Therefore, studies on how infection influences immune homeostasis and how the development of responses to a pathogen reflects what is known on immune regulation will be informative on how we can translate findings from our standard models into treatments usable in humans. One organism allows us to do just this. Bacteria of the genus Salmonella are devastating human pathogens. Nevertheless, many aspects of the diseases they cause can be successfully modelled in murine systems so that the infection is either resolving or non-resolving. This has the advantage of allowing the long-term impact of infection on immune function to be assessed. We propose to welcome key workers to write about their research that examine the consequence of Salmonella infection on the host and the elements of the bacterium that contribute to this. |
| format | Online |
| id | doab-20.500.12854ir-49602 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-496022024-03-30T23:22:41Z How Salmonella infection can inform on mechanisms of immune function and homeostasis Constantino Lopez-Macias Adam Cunningham R5-920 RC581-607 host response Infection microbiota Salmonella Non-typhoidal Salmonellosis Adaptive Immune system Typhoid Fever LeuO Innate immune system Vaccines thema EDItEUR::M Medicine and Nursing The use of model antigens such as haptens and ovalbumin has provided enormous insights into how immune responses develop, particularly to vaccine antigens. Furthermore, these studies are overwhelmingly performed in animals housed in clean facilities and are not known to have experienced overt clinical signs caused by infectious agents. Therefore, this is unlikely to reflect the impact more complex host-pathogen interactions can have on the host, nor the diversity in how immunity is regulated. Humans develop immune responses in the context of the periodic exposure to multiple pathogens and vaccines over a life-time. These are likely to have a long-lasting effect on who and what we are and how we respond to further antigen challenge. Therefore, studies on how infection influences immune homeostasis and how the development of responses to a pathogen reflects what is known on immune regulation will be informative on how we can translate findings from our standard models into treatments usable in humans. One organism allows us to do just this. Bacteria of the genus Salmonella are devastating human pathogens. Nevertheless, many aspects of the diseases they cause can be successfully modelled in murine systems so that the infection is either resolving or non-resolving. This has the advantage of allowing the long-term impact of infection on immune function to be assessed. We propose to welcome key workers to write about their research that examine the consequence of Salmonella infection on the host and the elements of the bacterium that contribute to this. 2021-02-11T15:34:52Z 2021-02-11T15:34:52Z 2017-02-03 17:04:57 2016 book 20292 16648714 9782889197996 https://directory.doabooks.org/handle/20.500.12854/49602 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/How_Salmonella_Infection_Can_Inform_on_Mechanisms_of_Immune_Function_and_Homeostasis/848#nogo http://journal.frontiersin.org/researchtopic/2175/how-salmonella-infection-can-inform-on-mechanisms-of-immune-function-and-homeostasis Frontiers Media SA 10.3389/978-2-88919-799-6 10.3389/978-2-88919-799-6 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889197996 143 open access |
| spellingShingle | R5-920 RC581-607 host response Infection microbiota Salmonella Non-typhoidal Salmonellosis Adaptive Immune system Typhoid Fever LeuO Innate immune system Vaccines thema EDItEUR::M Medicine and Nursing Constantino Lopez-Macias Adam Cunningham How Salmonella infection can inform on mechanisms of immune function and homeostasis |
| title | How Salmonella infection can inform on mechanisms of immune function and homeostasis |
| title_full | How Salmonella infection can inform on mechanisms of immune function and homeostasis |
| title_fullStr | How Salmonella infection can inform on mechanisms of immune function and homeostasis |
| title_full_unstemmed | How Salmonella infection can inform on mechanisms of immune function and homeostasis |
| title_short | How Salmonella infection can inform on mechanisms of immune function and homeostasis |
| title_sort | how salmonella infection can inform on mechanisms of immune function and homeostasis |
| topic | R5-920 RC581-607 host response Infection microbiota Salmonella Non-typhoidal Salmonellosis Adaptive Immune system Typhoid Fever LeuO Innate immune system Vaccines thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC581-607 host response Infection microbiota Salmonella Non-typhoidal Salmonellosis Adaptive Immune system Typhoid Fever LeuO Innate immune system Vaccines thema EDItEUR::M Medicine and Nursing |
| url | 20292 |
| work_keys_str_mv | AT constantinolopezmacias howsalmonellainfectioncaninformonmechanismsofimmunefunctionandhomeostasis AT adamcunningham howsalmonellainfectioncaninformonmechanismsofimmunefunctionandhomeostasis |