Human Tumor-Derived p53 Mutants: A Growing Family of Oncoproteins
TP53 gene mutations are present in more than half of all human cancers. The resulting proteins are mostly full-length with a single amino acid change and are abundantly expressed in cancer cells. Some of the mutant p53 proteins gain oncogenic functions (GOF) through which it actively contribute to t...
में बचाया:
| मुख्य लेखकों: | , |
|---|---|
| स्वरूप: | Online |
| भाषा: | अंग्रेज़ी |
| प्रकाशित: |
Frontiers Media SA
2021
|
| विषय: | |
| ऑनलाइन पहुंच: | 18348 |
| टैग: |
कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!
|
| _version_ | 1869523177310257152 |
|---|---|
| author | Giovanni Blandino Ygal Haupt |
| author_browse | Giovanni Blandino Ygal Haupt |
| author_facet | Giovanni Blandino Ygal Haupt |
| author_sort | Giovanni Blandino |
| collection | Directory of Open Access Books |
| description | TP53 gene mutations are present in more than half of all human cancers. The resulting proteins are mostly full-length with a single amino acid change and are abundantly expressed in cancer cells. Some of the mutant p53 proteins gain oncogenic functions (GOF) through which it actively contribute to the aberrant cell proliferation, increased resistance to apoptotic stimuli and ability to metastasize. Gain of function mutant p53 proteins can transcriptionally regulate the expression of a large plethora of target genes. This mainly occurs through the formation of oncogenic transcriptional competent complexes that include mutant p53 protein, known transcription factors, posttranslational modifiers and scaffold proteins. Mutant p53 protein can also transcriptionally regulate the expression of microRNAs, small non-coding RNAs that regulate gene expression at the posttranscriptional level. Each microRNA can putatively target the expression of hundred mRNAs and consequently impact on many cellular functions. Thus, gain of function mutant p53 proteins can exert their oncogenic activities through the modulation of both non-coding and coding regions of human genome. Over the past 3 decades, the regulation of p53 has been extensively studied. However, the regulation of mutant p53 remained largely unexplored. This snapshot focuses on recent discovery of mutant p53 GOF and regulation. |
| format | Online |
| id | doab-20.500.12854ir-49645 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-496452024-03-30T23:23:08Z Human Tumor-Derived p53 Mutants: A Growing Family of Oncoproteins Giovanni Blandino Ygal Haupt R5-920 RC254-282 mouse models mutant p53 dominant netagive therapies Oncogenic addiction gain of function thema EDItEUR::M Medicine and Nursing TP53 gene mutations are present in more than half of all human cancers. The resulting proteins are mostly full-length with a single amino acid change and are abundantly expressed in cancer cells. Some of the mutant p53 proteins gain oncogenic functions (GOF) through which it actively contribute to the aberrant cell proliferation, increased resistance to apoptotic stimuli and ability to metastasize. Gain of function mutant p53 proteins can transcriptionally regulate the expression of a large plethora of target genes. This mainly occurs through the formation of oncogenic transcriptional competent complexes that include mutant p53 protein, known transcription factors, posttranslational modifiers and scaffold proteins. Mutant p53 protein can also transcriptionally regulate the expression of microRNAs, small non-coding RNAs that regulate gene expression at the posttranscriptional level. Each microRNA can putatively target the expression of hundred mRNAs and consequently impact on many cellular functions. Thus, gain of function mutant p53 proteins can exert their oncogenic activities through the modulation of both non-coding and coding regions of human genome. Over the past 3 decades, the regulation of p53 has been extensively studied. However, the regulation of mutant p53 remained largely unexplored. This snapshot focuses on recent discovery of mutant p53 GOF and regulation. 2021-02-11T15:38:00Z 2021-02-11T15:38:00Z 2016-01-19 14:05:46 2016 book 18348 16648714 9782889199617 https://directory.doabooks.org/handle/20.500.12854/49645 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Human_Tumor-Derived_p53_Mutants_A_growing_Family_of_Oncoproteins/954 http://journal.frontiersin.org/researchtopic/3592/human-tumor-derived-p53-mutants-a-growing-family-of-oncoproteins Frontiers Media SA 10.3389/978-2-88919-961-7 10.3389/978-2-88919-961-7 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889199617 97 open access |
| spellingShingle | R5-920 RC254-282 mouse models mutant p53 dominant netagive therapies Oncogenic addiction gain of function thema EDItEUR::M Medicine and Nursing Giovanni Blandino Ygal Haupt Human Tumor-Derived p53 Mutants: A Growing Family of Oncoproteins |
| title | Human Tumor-Derived p53 Mutants: A Growing Family of Oncoproteins |
| title_full | Human Tumor-Derived p53 Mutants: A Growing Family of Oncoproteins |
| title_fullStr | Human Tumor-Derived p53 Mutants: A Growing Family of Oncoproteins |
| title_full_unstemmed | Human Tumor-Derived p53 Mutants: A Growing Family of Oncoproteins |
| title_short | Human Tumor-Derived p53 Mutants: A Growing Family of Oncoproteins |
| title_sort | human tumor derived p53 mutants a growing family of oncoproteins |
| topic | R5-920 RC254-282 mouse models mutant p53 dominant netagive therapies Oncogenic addiction gain of function thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC254-282 mouse models mutant p53 dominant netagive therapies Oncogenic addiction gain of function thema EDItEUR::M Medicine and Nursing |
| url | 18348 |
| work_keys_str_mv | AT giovanniblandino humantumorderivedp53mutantsagrowingfamilyofoncoproteins AT ygalhaupt humantumorderivedp53mutantsagrowingfamilyofoncoproteins |