Immunomodulatory Effects of Drugs for Treatment of Immune-Related Diseases
More than 90% of diseases possess immunological abnormalities. Disorders such as inflammation, hypersensitivity, autoimmunity and immunodeficiency are simple examples of how the immune system misinterprets its surroundings and goes awry. Multiple sclerosis, rheumatoid arthritis, systemic lupus eryth...
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| Materiálatiipa: | Online |
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Frontiers Media SA
2021
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| Liŋkkat: | 25597 |
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| _version_ | 1869524374338404352 |
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| author | Azzam A. Maghazachi |
| author_browse | Azzam A. Maghazachi |
| author_facet | Azzam A. Maghazachi |
| author_sort | Azzam A. Maghazachi |
| collection | Directory of Open Access Books |
| description | More than 90% of diseases possess immunological abnormalities. Disorders such as inflammation, hypersensitivity, autoimmunity and immunodeficiency are simple examples of how the immune system misinterprets its surroundings and goes awry. Multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel diseases, among many others are manifestations of immune cells attacking normal tissues. On the other hand, damping the immune system leads to diseases such as cancer, AIDS, and severe combined immunodeficiency. The last ten years witnessed an explosion in developing drugs that target the immune system. Several novel monoclonal antibodies have been approved for treatment of various diseases confirming that personalized medicine approach is robust in combating diseases. Hence, the future holds great promise for using personalized and targeted medicine rather than generalized medications that, in most circumstances, proven to be ineffective and characteristically exert side effects. Approaches such as generating novel adjuvants that can stimulate the immune system without harmful side effects, targeting inflammatory cytokines and chemokines, harnessing and activating innate immune cells such as natural killer cells or dendritic cells, are examples of future approaches to treat autoimmune diseases, AIDS, and various forms of cancer resulting from chronic inflammation. More recently, targeting immune checkpoint molecules have shown therapeutic response against lung cancer and melanoma. Identifying molecules involved in autophagy is another example of how personalized medicine might help treat patients with refractory asthma and autoimmune diseases. This topic introduces the reader to these novel approaches of manipulating the immune system and developing targeted therapeutic strategies for treatment of various diseases. |
| format | Online |
| id | doab-20.500.12854ir-49990 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-499902024-03-31T13:11:00Z Immunomodulatory Effects of Drugs for Treatment of Immune-Related Diseases Azzam A. Maghazachi R5-920 RC581-607 Drugs Multiple sclerosis NK cells Leukemia AIDS Adjuvants Lymphoma Autophagy Chemokines Cancer thema EDItEUR::M Medicine and Nursing More than 90% of diseases possess immunological abnormalities. Disorders such as inflammation, hypersensitivity, autoimmunity and immunodeficiency are simple examples of how the immune system misinterprets its surroundings and goes awry. Multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel diseases, among many others are manifestations of immune cells attacking normal tissues. On the other hand, damping the immune system leads to diseases such as cancer, AIDS, and severe combined immunodeficiency. The last ten years witnessed an explosion in developing drugs that target the immune system. Several novel monoclonal antibodies have been approved for treatment of various diseases confirming that personalized medicine approach is robust in combating diseases. Hence, the future holds great promise for using personalized and targeted medicine rather than generalized medications that, in most circumstances, proven to be ineffective and characteristically exert side effects. Approaches such as generating novel adjuvants that can stimulate the immune system without harmful side effects, targeting inflammatory cytokines and chemokines, harnessing and activating innate immune cells such as natural killer cells or dendritic cells, are examples of future approaches to treat autoimmune diseases, AIDS, and various forms of cancer resulting from chronic inflammation. More recently, targeting immune checkpoint molecules have shown therapeutic response against lung cancer and melanoma. Identifying molecules involved in autophagy is another example of how personalized medicine might help treat patients with refractory asthma and autoimmune diseases. This topic introduces the reader to these novel approaches of manipulating the immune system and developing targeted therapeutic strategies for treatment of various diseases. 2021-02-11T15:56:59Z 2021-02-11T15:56:59Z 2018-02-27 16:16:44 2017 book 25597 16648714 9782889452880 https://directory.doabooks.org/handle/20.500.12854/49990 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Immunomodulatory_Effects_of_Drugs_for_Treatment_of_Immune-Related_Diseases/1330 http://journal.frontiersin.org/researchtopic/4036/immunomodulatory-effects-of-drugs-for-treatment-of-immune-related-diseases Frontiers Media SA 10.3389/978-2-88945-288-0 10.3389/978-2-88945-288-0 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889452880 108 open access |
| spellingShingle | R5-920 RC581-607 Drugs Multiple sclerosis NK cells Leukemia AIDS Adjuvants Lymphoma Autophagy Chemokines Cancer thema EDItEUR::M Medicine and Nursing Azzam A. Maghazachi Immunomodulatory Effects of Drugs for Treatment of Immune-Related Diseases |
| title | Immunomodulatory Effects of Drugs for Treatment of Immune-Related Diseases |
| title_full | Immunomodulatory Effects of Drugs for Treatment of Immune-Related Diseases |
| title_fullStr | Immunomodulatory Effects of Drugs for Treatment of Immune-Related Diseases |
| title_full_unstemmed | Immunomodulatory Effects of Drugs for Treatment of Immune-Related Diseases |
| title_short | Immunomodulatory Effects of Drugs for Treatment of Immune-Related Diseases |
| title_sort | immunomodulatory effects of drugs for treatment of immune related diseases |
| topic | R5-920 RC581-607 Drugs Multiple sclerosis NK cells Leukemia AIDS Adjuvants Lymphoma Autophagy Chemokines Cancer thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC581-607 Drugs Multiple sclerosis NK cells Leukemia AIDS Adjuvants Lymphoma Autophagy Chemokines Cancer thema EDItEUR::M Medicine and Nursing |
| url | 25597 |
| work_keys_str_mv | AT azzamamaghazachi immunomodulatoryeffectsofdrugsfortreatmentofimmunerelateddiseases |