The Impact of Systems Medicine on Human Health and Disease
Complex diseases including diabetes, neurological disorders and cancer are results from a combination of genetic, environmental and lifestyle factors, and development of new prognostic tools for the treatment of such diseases requires a deep understanding of the mechanisms underlying cell functions....
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| Format: | Online |
| Language: | English |
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Frontiers Media SA
2021
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| Online Access: | 22991 |
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| _version_ | 1869524797015195648 |
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| author | Adil Mardinoglu Jens Nielsen |
| author_browse | Adil Mardinoglu Jens Nielsen |
| author_facet | Adil Mardinoglu Jens Nielsen |
| author_sort | Adil Mardinoglu |
| collection | Directory of Open Access Books |
| description | Complex diseases including diabetes, neurological disorders and cancer are results from a combination of genetic, environmental and lifestyle factors, and development of new prognostic tools for the treatment of such diseases requires a deep understanding of the mechanisms underlying cell functions. With the advances in high throughput technologies, biological components of cells can be measured with a very high resolution and these data can be used for investigating whole systems properties using a network-based approach. Systems medicine provides an integrative platform for studying the interactions between the biological components of the cell using a holistic approach and generating mechanistic explanations for the emergent systems properties. This inter-disciplinary field of study allows for understanding biological processes of cells in health and disease states, gaining new insights into what drives the appearance of the disease and finally identifying proteins and metabolites implicated in human disease. Systems medicine utilizes mathematical approaches to generate models which can be employed for designing new sets of experiments and for mapping the response of the system to perturbations quantitatively. These models, as well as the developed tools, can accelerate the emergence of personalized medicine which can transform the practice of medicine and offer better targets for drug development with minimum side effects. In this Research Topic, we aim to review the recently developed tools for modeling the cell behavior in normal and pathological states, recent advances and findings which increase our understanding of the molecular mechanisms involved in the progression of the diseases. |
| format | Online |
| id | doab-20.500.12854ir-50013 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-500132024-04-05T17:30:54Z The Impact of Systems Medicine on Human Health and Disease Adil Mardinoglu Jens Nielsen RC321-571 QP1-981 Q1-390 Metabolic Networks and Pathways Networks medicine Metabolic Diseases Systems Medicine Systems Biology biological networks thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Complex diseases including diabetes, neurological disorders and cancer are results from a combination of genetic, environmental and lifestyle factors, and development of new prognostic tools for the treatment of such diseases requires a deep understanding of the mechanisms underlying cell functions. With the advances in high throughput technologies, biological components of cells can be measured with a very high resolution and these data can be used for investigating whole systems properties using a network-based approach. Systems medicine provides an integrative platform for studying the interactions between the biological components of the cell using a holistic approach and generating mechanistic explanations for the emergent systems properties. This inter-disciplinary field of study allows for understanding biological processes of cells in health and disease states, gaining new insights into what drives the appearance of the disease and finally identifying proteins and metabolites implicated in human disease. Systems medicine utilizes mathematical approaches to generate models which can be employed for designing new sets of experiments and for mapping the response of the system to perturbations quantitatively. These models, as well as the developed tools, can accelerate the emergence of personalized medicine which can transform the practice of medicine and offer better targets for drug development with minimum side effects. In this Research Topic, we aim to review the recently developed tools for modeling the cell behavior in normal and pathological states, recent advances and findings which increase our understanding of the molecular mechanisms involved in the progression of the diseases. 2021-02-11T15:59:45Z 2021-02-11T15:59:45Z 2017-07-06 13:27:36 2017 book 22991 16648714 9782889451401 https://directory.doabooks.org/handle/20.500.12854/50013 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/The_impact_of_systems_medicine_on_human_health_and_disease/1156#nogo http://journal.frontiersin.org/researchtopic/3799/the-impact-of-systems-medicine-on-human-health-and-disease Frontiers Media SA 10.3389/978-2-88945-140-1 10.3389/978-2-88945-140-1 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889451401 96 open access |
| spellingShingle | RC321-571 QP1-981 Q1-390 Metabolic Networks and Pathways Networks medicine Metabolic Diseases Systems Medicine Systems Biology biological networks thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Adil Mardinoglu Jens Nielsen The Impact of Systems Medicine on Human Health and Disease |
| title | The Impact of Systems Medicine on Human Health and Disease |
| title_full | The Impact of Systems Medicine on Human Health and Disease |
| title_fullStr | The Impact of Systems Medicine on Human Health and Disease |
| title_full_unstemmed | The Impact of Systems Medicine on Human Health and Disease |
| title_short | The Impact of Systems Medicine on Human Health and Disease |
| title_sort | impact of systems medicine on human health and disease |
| topic | RC321-571 QP1-981 Q1-390 Metabolic Networks and Pathways Networks medicine Metabolic Diseases Systems Medicine Systems Biology biological networks thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 QP1-981 Q1-390 Metabolic Networks and Pathways Networks medicine Metabolic Diseases Systems Medicine Systems Biology biological networks thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 22991 |
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