Improving outcomes in cerebral palsy with early intervention: new translational approaches
The aim of this Research Topic was to collate articles describing prediction of outcomes of pre- and perinatal lesions leading to cerebral palsy, basic research in animal models and human subjects, and ideas for, and trials of, interventions in the first two years of life.CP arises from insults to t...
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| 格式: | Online |
| 語言: | 英语 |
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Frontiers Media SA
2021
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| 主題: | |
| 在線閱讀: | 17747 |
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| _version_ | 1869519638037004288 |
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| author | Anna Purna Basu Gavin John Clowry |
| author_browse | Anna Purna Basu Gavin John Clowry |
| author_facet | Anna Purna Basu Gavin John Clowry |
| author_sort | Anna Purna Basu |
| collection | Directory of Open Access Books |
| description | The aim of this Research Topic was to collate articles describing prediction of outcomes of pre- and perinatal lesions leading to cerebral palsy, basic research in animal models and human subjects, and ideas for, and trials of, interventions in the first two years of life.CP arises from insults to the sensorimotor cortex, subcortical axon tracts and subplate. The aetiology is complex and often multifactorial. The outcome is not simply a loss of voluntary control due to disruption of descending pathways, but also involves abnormal development of reflex and corticospinal circuitry. CP may be viewed as aberrant plasticity in response to a lesion, indeed, abnormalities in movement are subtle at first but develop subsequently. It is misleading to suppose that developmental mechanisms are self-reparative. The challenge is to understand activitydependent fine tuning of neural circuitry during normal development and to find how to promote desirable plasticity whilst limiting undesirable effects following developmental lesions. However, before proposing interventions, we have to develop our ability to predict the severity of neonatal insults.We solicited a variety of articles, including long and short reviews, original research and opinion pieces, from both basic scientists and clinicians. Likewise we, as editors, have complementary knowledge and experience in this area. Anna Basu is an academic pediatric neurologist and Gavin Clowry is a developmental neuroscientist. |
| format | Online |
| id | doab-20.500.12854ir-50066 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-500662024-03-30T23:22:32Z Improving outcomes in cerebral palsy with early intervention: new translational approaches Anna Purna Basu Gavin John Clowry R5-920 RC346-429 RJ1-570 outcome prediction Early Intervention Translational Medical Research diagnosis Cerebral Palsy thema EDItEUR::M Medicine and Nursing The aim of this Research Topic was to collate articles describing prediction of outcomes of pre- and perinatal lesions leading to cerebral palsy, basic research in animal models and human subjects, and ideas for, and trials of, interventions in the first two years of life.CP arises from insults to the sensorimotor cortex, subcortical axon tracts and subplate. The aetiology is complex and often multifactorial. The outcome is not simply a loss of voluntary control due to disruption of descending pathways, but also involves abnormal development of reflex and corticospinal circuitry. CP may be viewed as aberrant plasticity in response to a lesion, indeed, abnormalities in movement are subtle at first but develop subsequently. It is misleading to suppose that developmental mechanisms are self-reparative. The challenge is to understand activitydependent fine tuning of neural circuitry during normal development and to find how to promote desirable plasticity whilst limiting undesirable effects following developmental lesions. However, before proposing interventions, we have to develop our ability to predict the severity of neonatal insults.We solicited a variety of articles, including long and short reviews, original research and opinion pieces, from both basic scientists and clinicians. Likewise we, as editors, have complementary knowledge and experience in this area. Anna Basu is an academic pediatric neurologist and Gavin Clowry is a developmental neuroscientist. 2021-02-11T16:02:06Z 2021-02-11T16:02:06Z 2015-12-03 13:02:24 2015 book 17747 16648714 9782889195121 https://directory.doabooks.org/handle/20.500.12854/50066 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Improving_outcomes_in_cerebral_palsy_with_early_intervention_new_translational_approaches/486#nogo http://journal.frontiersin.org/researchtopic/1834/improving-outcomes-in-cerebral-palsy-with-early-intervention-new-translational-approaches Frontiers Media SA 10.3389/978-2-88919-512-1 10.3389/978-2-88919-512-1 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889195121 155 open access |
| spellingShingle | R5-920 RC346-429 RJ1-570 outcome prediction Early Intervention Translational Medical Research diagnosis Cerebral Palsy thema EDItEUR::M Medicine and Nursing Anna Purna Basu Gavin John Clowry Improving outcomes in cerebral palsy with early intervention: new translational approaches |
| title | Improving outcomes in cerebral palsy with early intervention: new translational approaches |
| title_full | Improving outcomes in cerebral palsy with early intervention: new translational approaches |
| title_fullStr | Improving outcomes in cerebral palsy with early intervention: new translational approaches |
| title_full_unstemmed | Improving outcomes in cerebral palsy with early intervention: new translational approaches |
| title_short | Improving outcomes in cerebral palsy with early intervention: new translational approaches |
| title_sort | improving outcomes in cerebral palsy with early intervention new translational approaches |
| topic | R5-920 RC346-429 RJ1-570 outcome prediction Early Intervention Translational Medical Research diagnosis Cerebral Palsy thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC346-429 RJ1-570 outcome prediction Early Intervention Translational Medical Research diagnosis Cerebral Palsy thema EDItEUR::M Medicine and Nursing |
| url | 17747 |
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