In vivo Cell Biology of Cerebral Cortical Development and Its Related Neurological Disorders: Cellular Insights into Neurogenesis and Neuronal Migration
The brain consists of a complex but precisely organized neural network, which provides the structural basis of higher order functions. Such a complex structure originates from a simple pseudostratified neuroepithelium. During the developing mammalian cerebral cortex, a cohort of neural progenitors,...
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Frontiers Media SA
2021
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| _version_ | 1869526589562159104 |
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| author | Margareta Nikolic Takeshi Kawauchi Yoko Arai |
| author_browse | Margareta Nikolic Takeshi Kawauchi Yoko Arai |
| author_facet | Margareta Nikolic Takeshi Kawauchi Yoko Arai |
| author_sort | Margareta Nikolic |
| collection | Directory of Open Access Books |
| description | The brain consists of a complex but precisely organized neural network, which provides the structural basis of higher order functions. Such a complex structure originates from a simple pseudostratified neuroepithelium. During the developing mammalian cerebral cortex, a cohort of neural progenitors, located near the ventricle, differentiates into neurons and exhibits multi-step modes of migration toward the pial surface. Tight regulation of neurogenesis and neuronal migration is essential for the determination of the neuron number in adult brains and the proper positioning of excitatory and inhibitory neurons in a specific layer, respectively. In addition, defects in neurogenesis and neuronal migration can cause several neurological disorders, such as microcephaly, periventricular heterotopia and lissencephaly. Recent advances in genetic approaches to study the developing cerebral cortex, as well as the use of a number of novel techniques, particularly in vivo electroporation and time-lapse analyses using explant slice cultures, have significantly increased our understanding of cortical development. These novel techniques have allowed for cell biological analyses of cerebral cortical development in vivo or ex vivo, showing that many cellular events, including endocytosis, cell adhesion, microtubule and actin cytoskeletal regulation, neurotransmitter release, stress response, the consequence of cellular crowding (physical force), dynamics of transcription factors, midbody release and polarity transition are required for neurogenesis and/or neuronal migration. The aim of this research topic is to highlight molecular and cellular mechanisms underlying cerebral cortical development and its related neurological disorders from the cell biological point of views, such as cell division, cell-cycle regulation, cytoskeletal organization, cell adhesion and membrane trafficking. The topic has been organized into three chapters: 1) neurogenesis and cell fate determination, 2) neuronal migration and 3) cortical development-related neurological disorders. We hope that the results and discussions contributed by all authors in this research topic will be broadly useful for further advances in basic research, as well as improvements in the etiology and care of patients suffering from neurological and psychiatric disorders. |
| format | Online |
| id | doab-20.500.12854ir-50091 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-500912024-04-05T17:31:20Z In vivo Cell Biology of Cerebral Cortical Development and Its Related Neurological Disorders: Cellular Insights into Neurogenesis and Neuronal Migration Margareta Nikolic Takeshi Kawauchi Yoko Arai RC321-571 Q1-390 Endocytosis Cell Cycle Periventricular heterotopia Lissencephaly neuronal migration Cell Division Cytoskeleton Microcephaly Neurogenesis Cell Adhesion thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences The brain consists of a complex but precisely organized neural network, which provides the structural basis of higher order functions. Such a complex structure originates from a simple pseudostratified neuroepithelium. During the developing mammalian cerebral cortex, a cohort of neural progenitors, located near the ventricle, differentiates into neurons and exhibits multi-step modes of migration toward the pial surface. Tight regulation of neurogenesis and neuronal migration is essential for the determination of the neuron number in adult brains and the proper positioning of excitatory and inhibitory neurons in a specific layer, respectively. In addition, defects in neurogenesis and neuronal migration can cause several neurological disorders, such as microcephaly, periventricular heterotopia and lissencephaly. Recent advances in genetic approaches to study the developing cerebral cortex, as well as the use of a number of novel techniques, particularly in vivo electroporation and time-lapse analyses using explant slice cultures, have significantly increased our understanding of cortical development. These novel techniques have allowed for cell biological analyses of cerebral cortical development in vivo or ex vivo, showing that many cellular events, including endocytosis, cell adhesion, microtubule and actin cytoskeletal regulation, neurotransmitter release, stress response, the consequence of cellular crowding (physical force), dynamics of transcription factors, midbody release and polarity transition are required for neurogenesis and/or neuronal migration. The aim of this research topic is to highlight molecular and cellular mechanisms underlying cerebral cortical development and its related neurological disorders from the cell biological point of views, such as cell division, cell-cycle regulation, cytoskeletal organization, cell adhesion and membrane trafficking. The topic has been organized into three chapters: 1) neurogenesis and cell fate determination, 2) neuronal migration and 3) cortical development-related neurological disorders. We hope that the results and discussions contributed by all authors in this research topic will be broadly useful for further advances in basic research, as well as improvements in the etiology and care of patients suffering from neurological and psychiatric disorders. 2021-02-11T16:03:30Z 2021-02-11T16:03:30Z 2016-01-19 14:05:46 2016 book 18349 16648714 9782889199624 https://directory.doabooks.org/handle/20.500.12854/50091 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/In_vivo_Cell_Biology_of_Cerebral_Cortical_Development_and_Its_Related_Neurological_Disorders_Cellul/1003#nogo http://journal.frontiersin.org/researchtopic/2703/in-vivo-cell-biology-of-cerebral-cortical-development-and-its-related-neurological-disorders-cellula Frontiers Media SA 10.3389/978-2-88919-962-4 10.3389/978-2-88919-962-4 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889199624 268 open access |
| spellingShingle | RC321-571 Q1-390 Endocytosis Cell Cycle Periventricular heterotopia Lissencephaly neuronal migration Cell Division Cytoskeleton Microcephaly Neurogenesis Cell Adhesion thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Margareta Nikolic Takeshi Kawauchi Yoko Arai In vivo Cell Biology of Cerebral Cortical Development and Its Related Neurological Disorders: Cellular Insights into Neurogenesis and Neuronal Migration |
| title | In vivo Cell Biology of Cerebral Cortical Development and Its Related Neurological Disorders: Cellular Insights into Neurogenesis and Neuronal Migration |
| title_full | In vivo Cell Biology of Cerebral Cortical Development and Its Related Neurological Disorders: Cellular Insights into Neurogenesis and Neuronal Migration |
| title_fullStr | In vivo Cell Biology of Cerebral Cortical Development and Its Related Neurological Disorders: Cellular Insights into Neurogenesis and Neuronal Migration |
| title_full_unstemmed | In vivo Cell Biology of Cerebral Cortical Development and Its Related Neurological Disorders: Cellular Insights into Neurogenesis and Neuronal Migration |
| title_short | In vivo Cell Biology of Cerebral Cortical Development and Its Related Neurological Disorders: Cellular Insights into Neurogenesis and Neuronal Migration |
| title_sort | in vivo cell biology of cerebral cortical development and its related neurological disorders cellular insights into neurogenesis and neuronal migration |
| topic | RC321-571 Q1-390 Endocytosis Cell Cycle Periventricular heterotopia Lissencephaly neuronal migration Cell Division Cytoskeleton Microcephaly Neurogenesis Cell Adhesion thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 Endocytosis Cell Cycle Periventricular heterotopia Lissencephaly neuronal migration Cell Division Cytoskeleton Microcephaly Neurogenesis Cell Adhesion thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 18349 |
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