In Vivo Imaging in Pharmacological Research
The discovery and development of a biological active molecule with therapeutic properties is an ever increasing complex task, highly unpredictable at the early stages and marked, in the end, by high rates of failure. As a consequence, the overall process leading to the production of a successful dru...
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| Autors principals: | , , |
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| Format: | Online |
| Idioma: | anglès |
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Frontiers Media SA
2021
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| Matèries: | |
| Accés en línia: | 24041 |
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| _version_ | 1869527510513876992 |
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| author | Nicolau Beckmann Albert D. Windhorst Igor A. Kaltashov |
| author_browse | Albert D. Windhorst Igor A. Kaltashov Nicolau Beckmann |
| author_facet | Nicolau Beckmann Albert D. Windhorst Igor A. Kaltashov |
| author_sort | Nicolau Beckmann |
| collection | Directory of Open Access Books |
| description | The discovery and development of a biological active molecule with therapeutic properties is an ever increasing complex task, highly unpredictable at the early stages and marked, in the end, by high rates of failure. As a consequence, the overall process leading to the production of a successful drug is very costly. The improvement of the net outcome in drug discovery and development would require, amongst other important factors, a good understanding of the molecular events that characterize the disease or pathology in order to better identify likely targets of interest, to optimize the interaction of an active agent (small molecule or macromolecule of natural or synthetic origin) with those targets, and to facilitate the study of the pharmacokinetics, pharmacodynamics and toxicity of an active agent in suitable models and in human subjects. The objective of this Research Topic is to highlight new developments and applications of imaging techniques with the objective of performing pharmacological studies in vivo, in animal models and in humans. In the domain of drug discovery, the pharmacological and biomedical questions constitute the center of attention. In this sense, it is fundamental to keep in mind the strengths and limitations of each analytical or imaging technique. At the end, the judicious application of the technique with the aim of supporting the search for answers to manifold questions arising during a long and painstaking path provides a continuous role for imaging within the complex area of drug discovery and development. |
| format | Online |
| id | doab-20.500.12854ir-50092 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-500922024-04-01T14:15:02Z In Vivo Imaging in Pharmacological Research Nicolau Beckmann Albert D. Windhorst Igor A. Kaltashov RM1-950 Q1-390 magnetic resonance imaging (MRI) computerized tomography(CT) positron emission tomography (PET) pharmacology single photon emission computed tomography (SPECT) imaging medical imaging ultrasound thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology The discovery and development of a biological active molecule with therapeutic properties is an ever increasing complex task, highly unpredictable at the early stages and marked, in the end, by high rates of failure. As a consequence, the overall process leading to the production of a successful drug is very costly. The improvement of the net outcome in drug discovery and development would require, amongst other important factors, a good understanding of the molecular events that characterize the disease or pathology in order to better identify likely targets of interest, to optimize the interaction of an active agent (small molecule or macromolecule of natural or synthetic origin) with those targets, and to facilitate the study of the pharmacokinetics, pharmacodynamics and toxicity of an active agent in suitable models and in human subjects. The objective of this Research Topic is to highlight new developments and applications of imaging techniques with the objective of performing pharmacological studies in vivo, in animal models and in humans. In the domain of drug discovery, the pharmacological and biomedical questions constitute the center of attention. In this sense, it is fundamental to keep in mind the strengths and limitations of each analytical or imaging technique. At the end, the judicious application of the technique with the aim of supporting the search for answers to manifold questions arising during a long and painstaking path provides a continuous role for imaging within the complex area of drug discovery and development. 2021-02-11T16:03:34Z 2021-02-11T16:03:34Z 2017-10-13 14:57:01 2017 book 24041 16648714 9782889452378 https://directory.doabooks.org/handle/20.500.12854/50092 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/In_Vivo_Imaging_in_Pharmacological_Research/1280 http://journal.frontiersin.org/researchtopic/3194/in-vivo-imaging-in-pharmacological-research Frontiers Media SA 10.3389/978-2-88945-237-8 10.3389/978-2-88945-237-8 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889452378 222 open access |
| spellingShingle | RM1-950 Q1-390 magnetic resonance imaging (MRI) computerized tomography(CT) positron emission tomography (PET) pharmacology single photon emission computed tomography (SPECT) imaging medical imaging ultrasound thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Nicolau Beckmann Albert D. Windhorst Igor A. Kaltashov In Vivo Imaging in Pharmacological Research |
| title | In Vivo Imaging in Pharmacological Research |
| title_full | In Vivo Imaging in Pharmacological Research |
| title_fullStr | In Vivo Imaging in Pharmacological Research |
| title_full_unstemmed | In Vivo Imaging in Pharmacological Research |
| title_short | In Vivo Imaging in Pharmacological Research |
| title_sort | in vivo imaging in pharmacological research |
| topic | RM1-950 Q1-390 magnetic resonance imaging (MRI) computerized tomography(CT) positron emission tomography (PET) pharmacology single photon emission computed tomography (SPECT) imaging medical imaging ultrasound thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| topic_facet | RM1-950 Q1-390 magnetic resonance imaging (MRI) computerized tomography(CT) positron emission tomography (PET) pharmacology single photon emission computed tomography (SPECT) imaging medical imaging ultrasound thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| url | 24041 |
| work_keys_str_mv | AT nicolaubeckmann invivoimaginginpharmacologicalresearch AT albertdwindhorst invivoimaginginpharmacologicalresearch AT igorakaltashov invivoimaginginpharmacologicalresearch |