Inflammation in the CNS: Advancing the Field Using Intravital Imaging
Inflammation of the CNS can have devastating, long-lived, and in some cases fatal consequences for patients. The stimuli that can induce CNS inflammation are diverse, and include infectious agents, autoimmune responses against CNS-expressed antigens, and sterile inflammation following ischemia or tr...
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| Formaat: | Online |
| Taal: | Engels |
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Frontiers Media SA
2021
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| Online toegang: | 25664 |
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| _version_ | 1869526760278720512 |
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| author | Saparna Pai Wolfgang Weninger Michael J. Hickey |
| author_browse | Michael J. Hickey Saparna Pai Wolfgang Weninger |
| author_facet | Saparna Pai Wolfgang Weninger Michael J. Hickey |
| author_sort | Saparna Pai |
| collection | Directory of Open Access Books |
| description | Inflammation of the CNS can have devastating, long-lived, and in some cases fatal consequences for patients. The stimuli that can induce CNS inflammation are diverse, and include infectious agents, autoimmune responses against CNS-expressed antigens, and sterile inflammation following ischemia or traumatic injury. In these conditions, cells of the immune system play central roles in promulgation and resolution of the inflammatory response. However, the immunological mechanisms at work in these diverse responses differ according to the nature of the response. Our understanding of the actions of immune cells in the CNS has been restricted by the difficulty in visualising leukocytes as they undergo recruitment from the cerebral microvasculature and following their entry into the CNS parenchyma. However, advances in in vivo microscopy over the last 10-15 years have overcome many of these difficulties, and studies using these forms of microscopy have revealed a wealth of new information regarding the cellular and molecular mechanisms of CNS inflammation. This Research Topic brings together state of the art reviews examining the use of in vivo imaging in investigating inflammation and leukocyte behaviour in the CNS. Papers in this Research Topic describe how in vivo microscopy has increased our understanding of the actions of immune cells in the inflamed CNS, following various stimuli including autoimmunity, infection and sterile inflammation. |
| format | Online |
| id | doab-20.500.12854ir-50187 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-501872024-03-31T13:09:49Z Inflammation in the CNS: Advancing the Field Using Intravital Imaging Saparna Pai Wolfgang Weninger Michael J. Hickey R5-920 RC581-607 Intravital Imaging Brain Inflammation CNS disorders Leukocytes thema EDItEUR::M Medicine and Nursing Inflammation of the CNS can have devastating, long-lived, and in some cases fatal consequences for patients. The stimuli that can induce CNS inflammation are diverse, and include infectious agents, autoimmune responses against CNS-expressed antigens, and sterile inflammation following ischemia or traumatic injury. In these conditions, cells of the immune system play central roles in promulgation and resolution of the inflammatory response. However, the immunological mechanisms at work in these diverse responses differ according to the nature of the response. Our understanding of the actions of immune cells in the CNS has been restricted by the difficulty in visualising leukocytes as they undergo recruitment from the cerebral microvasculature and following their entry into the CNS parenchyma. However, advances in in vivo microscopy over the last 10-15 years have overcome many of these difficulties, and studies using these forms of microscopy have revealed a wealth of new information regarding the cellular and molecular mechanisms of CNS inflammation. This Research Topic brings together state of the art reviews examining the use of in vivo imaging in investigating inflammation and leukocyte behaviour in the CNS. Papers in this Research Topic describe how in vivo microscopy has increased our understanding of the actions of immune cells in the inflamed CNS, following various stimuli including autoimmunity, infection and sterile inflammation. 2021-02-11T16:10:30Z 2021-02-11T16:10:30Z 2018-02-27 16:16:45 2017 book 25664 16648714 9782889453641 https://directory.doabooks.org/handle/20.500.12854/50187 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/books/Inflammation_in_the_CNS_Advancing_the_Field_Using_Intravital_Imaging/1415 https://www.frontiersin.org/research-topics/3564/inflammation-in-the-cns-advancing-the-field-using-intravital-imaging Frontiers Media SA 10.3389/978-2-88945-364-1 10.3389/978-2-88945-364-1 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889453641 108 open access |
| spellingShingle | R5-920 RC581-607 Intravital Imaging Brain Inflammation CNS disorders Leukocytes thema EDItEUR::M Medicine and Nursing Saparna Pai Wolfgang Weninger Michael J. Hickey Inflammation in the CNS: Advancing the Field Using Intravital Imaging |
| title | Inflammation in the CNS: Advancing the Field Using Intravital Imaging |
| title_full | Inflammation in the CNS: Advancing the Field Using Intravital Imaging |
| title_fullStr | Inflammation in the CNS: Advancing the Field Using Intravital Imaging |
| title_full_unstemmed | Inflammation in the CNS: Advancing the Field Using Intravital Imaging |
| title_short | Inflammation in the CNS: Advancing the Field Using Intravital Imaging |
| title_sort | inflammation in the cns advancing the field using intravital imaging |
| topic | R5-920 RC581-607 Intravital Imaging Brain Inflammation CNS disorders Leukocytes thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC581-607 Intravital Imaging Brain Inflammation CNS disorders Leukocytes thema EDItEUR::M Medicine and Nursing |
| url | 25664 |
| work_keys_str_mv | AT saparnapai inflammationinthecnsadvancingthefieldusingintravitalimaging AT wolfgangweninger inflammationinthecnsadvancingthefieldusingintravitalimaging AT michaeljhickey inflammationinthecnsadvancingthefieldusingintravitalimaging |