Investigating and harnessing T-cell functions with engineered immune receptors and their ligands
T-cells are an essential component of the immune system that provide protection against pathogen infections and cancer and are involved in the aetiology of numerous autoimmune and autoinflammatory pathologies. Their importance in disease, the relative ease to isolate, expand and manipulate them ex v...
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| Formato: | Online |
| Idioma: | inglês |
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Frontiers Media SA
2021
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| Acesso em linha: | 17805 |
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| _version_ | 1869528693614837760 |
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| author | Bruno Laugel |
| author_browse | Bruno Laugel |
| author_facet | Bruno Laugel |
| author_sort | Bruno Laugel |
| collection | Directory of Open Access Books |
| description | T-cells are an essential component of the immune system that provide protection against pathogen infections and cancer and are involved in the aetiology of numerous autoimmune and autoinflammatory pathologies. Their importance in disease, the relative ease to isolate, expand and manipulate them ex vivo have put T-cells at the forefront of basic and translational research in immunology. Decades of study have shed some light on the unique way T-cells integrate extrinsic environmental cues influencing an activation program triggered by interactions between peptide-MHC complexes and the antigen-recognition machinery constituted of clonally distributed T-cell receptors and their co-receptor CD4 or CD8. The manipulation of these molecular determinants in cellular systems or as recombinant proteins has considerably enhanced our ability to understand antigen-specific T-cell activation, to monitor ongoing T-cell responses and to exploit T-cells for therapy. Even though these principles have given numerous insights in the biology of CD8+ T-cells that translate into promising therapeutic prospects, as illustrated by recent breakthroughs in cancer therapy, they have proven more challenging to apply to CD4+ T-cells. This Research Topics aims to provide a comprehensive view of the recent insights provided by the use of engineered antigen receptors and their ligands on T-cell activation and how they have been or could be harnessed to design efficient immunotherapies. |
| format | Online |
| id | doab-20.500.12854ir-50630 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-506302024-03-31T13:10:00Z Investigating and harnessing T-cell functions with engineered immune receptors and their ligands Bruno Laugel R5-920 RC581-607 T-cells tcr Immunosuppression cancer immunotherapy pMHC thema EDItEUR::M Medicine and Nursing T-cells are an essential component of the immune system that provide protection against pathogen infections and cancer and are involved in the aetiology of numerous autoimmune and autoinflammatory pathologies. Their importance in disease, the relative ease to isolate, expand and manipulate them ex vivo have put T-cells at the forefront of basic and translational research in immunology. Decades of study have shed some light on the unique way T-cells integrate extrinsic environmental cues influencing an activation program triggered by interactions between peptide-MHC complexes and the antigen-recognition machinery constituted of clonally distributed T-cell receptors and their co-receptor CD4 or CD8. The manipulation of these molecular determinants in cellular systems or as recombinant proteins has considerably enhanced our ability to understand antigen-specific T-cell activation, to monitor ongoing T-cell responses and to exploit T-cells for therapy. Even though these principles have given numerous insights in the biology of CD8+ T-cells that translate into promising therapeutic prospects, as illustrated by recent breakthroughs in cancer therapy, they have proven more challenging to apply to CD4+ T-cells. This Research Topics aims to provide a comprehensive view of the recent insights provided by the use of engineered antigen receptors and their ligands on T-cell activation and how they have been or could be harnessed to design efficient immunotherapies. 2021-02-11T16:39:47Z 2021-02-11T16:39:47Z 2015-12-10 11:59:06 2015 book 17805 16648714 9782889194131 https://directory.doabooks.org/handle/20.500.12854/50630 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Investigating_and_harnessing_T-cell_functions_with_engineered_immune_receptors_and_their_ligands/385 http://journal.frontiersin.org/researchtopic/991/investigating-and-harnessing-t-cell-functions-with-engineered-immune-receptors-and-their-ligands Frontiers Media SA 10.3389/978-2-88919-413-1 10.3389/978-2-88919-413-1 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889194131 191 open access |
| spellingShingle | R5-920 RC581-607 T-cells tcr Immunosuppression cancer immunotherapy pMHC thema EDItEUR::M Medicine and Nursing Bruno Laugel Investigating and harnessing T-cell functions with engineered immune receptors and their ligands |
| title | Investigating and harnessing T-cell functions with engineered immune receptors and their ligands |
| title_full | Investigating and harnessing T-cell functions with engineered immune receptors and their ligands |
| title_fullStr | Investigating and harnessing T-cell functions with engineered immune receptors and their ligands |
| title_full_unstemmed | Investigating and harnessing T-cell functions with engineered immune receptors and their ligands |
| title_short | Investigating and harnessing T-cell functions with engineered immune receptors and their ligands |
| title_sort | investigating and harnessing t cell functions with engineered immune receptors and their ligands |
| topic | R5-920 RC581-607 T-cells tcr Immunosuppression cancer immunotherapy pMHC thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC581-607 T-cells tcr Immunosuppression cancer immunotherapy pMHC thema EDItEUR::M Medicine and Nursing |
| url | 17805 |
| work_keys_str_mv | AT brunolaugel investigatingandharnessingtcellfunctionswithengineeredimmunereceptorsandtheirligands |