Involvements of TRP Channels and Oxidative Stress in Pain
Undoubtedly, pain conditions the quality of life of millions of people worldwide suffering a wide range of diseases. Major research efforts are being made by the international scientific community to determine the mechanisms underlying nociception. Growing evidence points out a complex network inclu...
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| Główni autorzy: | , , , |
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| Format: | Online |
| Język: | angielski |
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Frontiers Media SA
2021
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| Hasła przedmiotowe: | |
| Dostęp online: | 31994 |
| Etykiety: |
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| _version_ | 1869514199198072832 |
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| author | Mustafa Naziroglu Jose A. Pariente Laszlo Pecze Cristina Carrasco |
| author_browse | Cristina Carrasco Jose A. Pariente Laszlo Pecze Mustafa Naziroglu |
| author_facet | Mustafa Naziroglu Jose A. Pariente Laszlo Pecze Cristina Carrasco |
| author_sort | Mustafa Naziroglu |
| collection | Directory of Open Access Books |
| description | Undoubtedly, pain conditions the quality of life of millions of people worldwide suffering a wide range of diseases. Major research efforts are being made by the international scientific community to determine the mechanisms underlying nociception. Growing evidence points out a complex network including oxidative and nitrosative stress, inflammatory response and cation signaling. In this sense, transient receptor potential (TRP) channels have attracted researchers’ attention. Expression levels are very different in tissues and cells mediating a myriad of processes in our organism. At the neurological level, it has been observed that the expression levels of four TRP channels (TRPA1, TRPM2, TRPV1, and TRPV4) are high in neurons related to nociception, including dorsal root ganglion and trigeminal ganglia neurons. For this reason, this research field promises to shed light on this intricated matrix linking oxidative stress, calcium signaling (via TRP channels), and inflammatory signals in different pain modalities, including neuropathic pain and chemotherapy-induced peripheral pain. In such a way, all this intense research activity will enable us to design individual and rational treatment strategies for pain relief, such as the use of molecular neurosurgery. |
| format | Online |
| id | doab-20.500.12854ir-50653 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-506532024-03-31T22:45:04Z Involvements of TRP Channels and Oxidative Stress in Pain Mustafa Naziroglu Jose A. Pariente Laszlo Pecze Cristina Carrasco QP1-981 Q1-390 cation signaling pain nervous system nociception TRP channels oxidative stress thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology Undoubtedly, pain conditions the quality of life of millions of people worldwide suffering a wide range of diseases. Major research efforts are being made by the international scientific community to determine the mechanisms underlying nociception. Growing evidence points out a complex network including oxidative and nitrosative stress, inflammatory response and cation signaling. In this sense, transient receptor potential (TRP) channels have attracted researchers’ attention. Expression levels are very different in tissues and cells mediating a myriad of processes in our organism. At the neurological level, it has been observed that the expression levels of four TRP channels (TRPA1, TRPM2, TRPV1, and TRPV4) are high in neurons related to nociception, including dorsal root ganglion and trigeminal ganglia neurons. For this reason, this research field promises to shed light on this intricated matrix linking oxidative stress, calcium signaling (via TRP channels), and inflammatory signals in different pain modalities, including neuropathic pain and chemotherapy-induced peripheral pain. In such a way, all this intense research activity will enable us to design individual and rational treatment strategies for pain relief, such as the use of molecular neurosurgery. 2021-02-11T16:40:34Z 2021-02-11T16:40:34Z 2019-01-23 14:53:43 2018 book 31994 16648714 9782889455959 https://directory.doabooks.org/handle/20.500.12854/50653 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/5551/involvements-of-trp-channels-and-oxidative-stress-in-pain Frontiers Media SA 10.3389/978-2-88945-595-9 10.3389/978-2-88945-595-9 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889455959 126 open access |
| spellingShingle | QP1-981 Q1-390 cation signaling pain nervous system nociception TRP channels oxidative stress thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology Mustafa Naziroglu Jose A. Pariente Laszlo Pecze Cristina Carrasco Involvements of TRP Channels and Oxidative Stress in Pain |
| title | Involvements of TRP Channels and Oxidative Stress in Pain |
| title_full | Involvements of TRP Channels and Oxidative Stress in Pain |
| title_fullStr | Involvements of TRP Channels and Oxidative Stress in Pain |
| title_full_unstemmed | Involvements of TRP Channels and Oxidative Stress in Pain |
| title_short | Involvements of TRP Channels and Oxidative Stress in Pain |
| title_sort | involvements of trp channels and oxidative stress in pain |
| topic | QP1-981 Q1-390 cation signaling pain nervous system nociception TRP channels oxidative stress thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| topic_facet | QP1-981 Q1-390 cation signaling pain nervous system nociception TRP channels oxidative stress thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| url | 31994 |
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